Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
edited by and Benjamin Wolozin
submission deadline 30 Sep 2025 | Viewed by 58 | Submission Open
Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 5 Oct 2025 | 3 articles | Viewed by 2878 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
The Interplay of G-Protein-Coupled Receptor Signaling between Humans and Diseases
edited by Victor Garcia
submission deadline 10 Oct 2025 | 1 articles | Viewed by 5402 | Submission Open
Keywords: G-proteins; G-protein-coupled receptors; G-protein-independent signaling; cAMP signals
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 10 Oct 2025 | Viewed by 69 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
Ras Family of Genes and Proteins: Structure, Function and Regulation
edited by , and Rosula Garcia-Navas
submission deadline 15 Oct 2025 | 2 articles | Viewed by 1851 | Submission Open
Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF
Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health
edited by
submission deadline 15 Oct 2025 | 1 articles | Viewed by 1478 | Submission Open
Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination;   ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.
(This special issue belongs to the Section Cellular Pathology)
Advances in Understanding Inflammation in Atherosclerosis: From Mechanisms to Therapeutic Targets
edited by Yaw Asare and Michael Lacy
submission deadline 15 Oct 2025 | Viewed by 595 | Submission Open
Keywords: atherosclerosis; inflammatory pathways; monocytes/macrophages; endothelial cells; innate immunity; inflammasome; IL-1β ; cytokines and chemokines; neutrophils; epigenetic mechanisms; adaptive immunity; small-molecule inhibitors; T cells; B cells
(This special issue belongs to the Section Cellular Pathology)
LPS-Induced Inflammatory Diseases
edited by and
submission deadline 15 Oct 2025 | Viewed by 217 | Submission Open
Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function submission deadline 15 Oct 2025 | Viewed by 209 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 15 Oct 2025 | Viewed by 187 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
AI, CRISPR, and Molecular Mechanisms in Precision Medicine
edited by Karim Daliri
submission deadline 15 Oct 2025 | Viewed by 81 | Submission Open
Keywords: CRISPR; gene therapy; precision medicine
(This special issue belongs to the Section Cell Methods)
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 15 Oct 2025 | Viewed by 75 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections
edited by
submission deadline 15 Oct 2025 | Viewed by 68 | Submission Open
Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication
Regulation of the Subcellular Compartmentalization of Signaling Pathways by Post-Translational Modifications
edited by Jürgen Fritsch
submission deadline 15 Oct 2025 | Viewed by 66 | Submission Open
Keywords: phosphorylation; ubiquitination; acetylation; acylation; methylation; sumoylation; glycosylation; neddylation; ribosylation; oxidation; proteolysis
Genetic and Genomic Insights into Complex Human Diseases: Advances, Challenges and Integrative Approaches
edited by Tianxiao Huan and Chan Zhou
submission deadline 15 Oct 2025 | Viewed by 20 | Submission Open
Keywords: genetics; genomics; proteomics; complex diseases; multi-omics; machine learning
Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer
edited by Giusi Alberti and
submission deadline 16 Oct 2025 | Viewed by 69 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research
Molecular Mechanisms of Autism Spectrum Disorder
edited by Tanya Gandhi and
submission deadline 20 Oct 2025 | 4 articles | Viewed by 8659 | Submission Open
Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies
(This special issue belongs to the Section Cells of the Nervous System)
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 20 Oct 2025 | 5 articles | Viewed by 6329 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
(This special issue belongs to the Section Cells of the Nervous System)
New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition submission deadline 20 Oct 2025 | 4 articles | Viewed by 4666 | Submission Open
Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy
(This special issue belongs to the Section Cellular Pathology)
Sperm Biology and Reproductive Health—Second Edition
edited by and
submission deadline 20 Oct 2025 | 2 articles | Viewed by 1260 | Submission Open
Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation
Experimental Systems to Model Aging Processes
edited by , and Ralf Dahm
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1223 | Submission Open
Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker
(This special issue belongs to the Section Cellular Aging)
Cell Therapy for Retinal Diseases submission deadline 20 Oct 2025 | Viewed by 275 | Submission Open
Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration
(This special issue belongs to the Section Tissues and Organs)
Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition submission deadline 20 Oct 2025 | Viewed by 153 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
Immune Response in HIV Infection, Pathogenesis and Persistence
edited by Suvadip Mallick
submission deadline 20 Oct 2025 | Viewed by 127 | Submission Open
Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints
(This special issue belongs to the Section Cellular Immunology)
New Molecular Insights into Hepatitis and Hepatic Cancer
edited by
submission deadline 20 Oct 2025 | Viewed by 109 | Submission Open
Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances
(This special issue belongs to the Section Cellular Pathology)
New Advances in Anticancer Therapy
edited by
submission deadline 20 Oct 2025 | Viewed by 85 | Submission Open
Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology
(This special issue belongs to the Section Cellular Pathology)
Autophagy in Neurological Disorders submission deadline 20 Oct 2025 | Viewed by 84 | Submission Open
Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents
(This special issue belongs to the Section Cells of the Nervous System)
The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses submission deadline 20 Oct 2025 | Viewed by 78 | Submission Open
Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications
(This special issue belongs to the Section Cellular Pathology)
Cell Death and Its Clearance in Health and Disease
edited by
submission deadline 20 Oct 2025 | Viewed by 78 | Submission Open
Keywords: cell death; phagocytosis; immune homeostasis; inflammation
(This special issue belongs to the Section Cellular Pathology)
Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
edited by Roberta Montanari and
submission deadline 20 Oct 2025 | Viewed by 51 | Submission Open
Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms
(This special issue belongs to the Section Cellular Biophysics)
Adult Stem Cells in Human Disease
edited by Esther Wolfs, Tim Vangansewinkel and
submission deadline 25 Oct 2025 | 1 articles | Viewed by 2361 | Submission Open
Keywords: dental pulp stem cells; disease; regenerative medicine; disease modeling
(This special issue belongs to the Section Stem Cells)
3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures submission deadline 25 Oct 2025 | 1 articles | Viewed by 841 | Submission Open
Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling
(This special issue belongs to the Section Cell Methods)
Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease
edited by
submission deadline 25 Oct 2025 | Viewed by 122 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders
(This special issue belongs to the Section Cells of the Nervous System)
Regenerating Poorly Vascularized Tissues
edited by Simone Pacini
submission deadline 25 Oct 2025 | Viewed by 101 | Submission Open
Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation
(This special issue belongs to the Section Tissues and Organs)
Molecular Anatomy and Function of Sensory Organs and Sensory Tissues
edited by
submission deadline 25 Oct 2025 | Viewed by 86 | Submission Open
Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs
(This special issue belongs to the Section Tissues and Organs)
Therapeutic Targeting of MicroRNAs in Human Cancer
edited by
submission deadline 28 Oct 2025 | Viewed by 81 | Submission Open
Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies
(This special issue belongs to the Section Cell Methods)
Advances in Cellular and Molecular Treatment of Autoimmune Diseases—Second Edition submission deadline 30 Oct 2025 | Viewed by 187 | Submission Open
Keywords: autoimmune diseases; disease activity; TNFa inhibitors; tocilizumab; infliximab; golimumab; etanercept; JAK inhibitors; cellular targets; molecular targets
(This special issue belongs to the Section Cellular Immunology)
Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling
edited by Jianjie Ma, Long-Sheng Song, and
submission deadline 30 Oct 2025 | Viewed by 80 | Submission Open
Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease
Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis submission deadline 30 Oct 2025 | Viewed by 79 | Submission Open
Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis
(This special issue belongs to the Section Cellular Pathology)
New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets
edited by
submission deadline 30 Oct 2025 | Viewed by 74 | Submission Open
Keywords: cancer; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Immunology)
Molecular Cell Biology of T Cells in Cancer and Infectious Diseases
edited by and João Viola
submission deadline 30 Oct 2025 | Viewed by 71 | Submission Open
Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism
(This special issue belongs to the Section Cellular Immunology)
Perinatal Brain Injury—from Pathophysiology to Therapy
edited by Cora H.A. Nijboer, and
submission deadline 31 Oct 2025 | 6 articles | Viewed by 10144 | Submission Open
Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells
(This special issue belongs to the Section Cells of the Nervous System)
Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy submission deadline 31 Oct 2025 | 3 articles | Viewed by 7757 | Submission Open
Keywords: gastrointestinal cancer; gastric cancer; colorectal cancer; esophageal cancer; liver cancer; pancreatic cancer; inflammatory bowel disease; miRNAs; in vitro and in vivo models; molecular networks; molecular pathways; translational medicine; epithelial barrier functions/processes
(This special issue belongs to the Section Cellular Pathology)
Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory
edited by
submission deadline 31 Oct 2025 | 2 articles | Viewed by 3578 | Submission Open
Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Immune Cell Effect on the Endothelium
edited by and Margarita Lamprou
submission deadline 31 Oct 2025 | 1 articles | Viewed by 3542 | Submission Open
Keywords: immune cells; endothelial cells; cytokines; extracellular vesicles; angiogenesis; vascular permeability
(This special issue belongs to the Section Cellular Immunology)
Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases submission deadline 31 Oct 2025 | 2 articles | Viewed by 3152 | Submission Open
Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha
Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration submission deadline 31 Oct 2025 | 4 articles | Viewed by 2560 | Submission Open
Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases
(This special issue belongs to the Section Tissues and Organs)
Natural Killer (NK) Cells in Immunity: Limitations and Potential
edited by Rehan Mujeeb Faridi
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1315 | Submission Open
Keywords: natural killer cells; adaptive NK cells; infection
(This special issue belongs to the Section Cellular Immunology)
How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies submission deadline 31 Oct 2025 | 2 articles | Viewed by 1275 | Submission Open
Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention
(This special issue belongs to the Section Cell Microenvironment)
Glial Cells: Physiological and Pathological Perspective
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1074 | Submission Open
Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies
(This special issue belongs to the Section Cells of the Nervous System)
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