Immune Cell Effect on the Endothelium

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 3231

Special Issue Editors


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Guest Editor

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Guest Editor
Department of Pharmacy, University of Patras, 26504 Rion, Greece
Interests: bone angiogenesis; endothelial cells; permeability; metastasis

Special Issue Information

Dear Colleagues,

Cell-to-cell communication among diverse cell types plays a vital role in tissue and organism homeostasis. At the same time, dysregulated intercellular communication shapes the pathophysiology of multiple diseases. The endothelial cells participate in the pathophysiology of inflammatory disorders, including cancer, and their behavior is regulated by different cell types, such as immune cells, fibroblasts and tumor cells in the case of malignancies. This Special Issue focuses on the reciprocal interaction between immune and endothelial cells; the means of this interaction, such as cytokines or extracellular vesicles; the molecular mechanisms; and its effect on vascular physiology or pathophysiology and the characteristic of inflammatory diseases.

Dr. Constantinos Mikelis
Dr. Margarita Lamprou
Guest Editors

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Keywords

  • immune cells
  • endothelial cells
  • cytokines
  • extracellular vesicles
  • angiogenesis
  • vascular permeability

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Published Papers (1 paper)

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Review

18 pages, 1566 KiB  
Review
The Role of Soluble CD163 (sCD163) in Human Physiology and Pathophysiology
by Andriana Plevriti, Margarita Lamprou, Eleni Mourkogianni, Nikolaos Skoulas, Maria Giannakopoulou, Md Sanaullah Sajib, Zhiyong Wang, George Mattheolabakis, Antonios Chatzigeorgiou, Antonia Marazioti and Constantinos M. Mikelis
Cells 2024, 13(20), 1679; https://doi.org/10.3390/cells13201679 - 11 Oct 2024
Cited by 6 | Viewed by 2999
Abstract
Soluble CD163 (sCD163) is a circulating inflammatory mediator, indicative of acute and chronic, systemic and non-systemic inflammatory conditions. It is the cleavage outcome, consisting of almost the entire extracellular domain, of the CD163, a receptor expressed in monocytic lineages. Its expression is proportional [...] Read more.
Soluble CD163 (sCD163) is a circulating inflammatory mediator, indicative of acute and chronic, systemic and non-systemic inflammatory conditions. It is the cleavage outcome, consisting of almost the entire extracellular domain, of the CD163, a receptor expressed in monocytic lineages. Its expression is proportional to the abundance of CD163+ macrophages. Various mechanisms trigger the shedding of the CD163 receptor or the accumulation of CD163-expressing macrophages, inducing the sCD163 concentration in the circulation and bodily fluids. The activities of sCD163 range from hemoglobin (Hb) scavenging, macrophage marker, decoy receptor for cytokines, participation in immune defense mechanisms, and paracrine effects in various tissues, including the endothelium. It is an established marker of macrophage activation and thus participates in many diseases, including chronic inflammatory conditions, such as atherosclerosis, asthma, and rheumatoid arthritis; acute inflammatory conditions, such as sepsis, hepatitis, and malaria; insulin resistance; diabetes; and tumors. The sCD163 levels have been correlated with the severity, stage of the disease, and clinical outcome for many of these conditions. This review article summarizes the expression and role of sCD163 and its precursor protein, CD163, outlines the sCD163 generation mechanisms, the biological activities, and the known underlying molecular mechanisms, with an emphasis on its impact on the endothelium and its contribution in the pathophysiology of human diseases. Full article
(This article belongs to the Special Issue Immune Cell Effect on the Endothelium)
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