Experimental Systems to Model Aging Processes

Dear Colleagues,

This Special Issue of Cells on "Experimental Systems to Model Aging Processes" aims to gather contributions from internationally leading aging researchers on model systems—ranging from traditional to emerging models—used to elucidate the mechanisms underlying aging. Contributions can be in the form of original scientific articles and reviews.

Aging is driven by a range of molecular and subcellular processes, which include genetic, epigenetic, and genomic alterations; the loss of proteostasis; dysregulated autophagy; metabolic dysfunctions; or the malfunction of cellular organelles. Additionally, aging is influenced by inter-cellular dynamics, including changes in signaling pathways, inflammatory processes, and microbial balance. These events, whether individually or interconnected, can be modeled in study systems both in vitro and in vivo, as well as ex vivo and in silico.

Elucidating these processes in experimental systems—from the most reductionist to the most complex—paves the way for identifying new molecular and cellular mechanisms, as well as potential targets to mitigate the negative outcomes associated with aging, including diseases such as cancer, osteoporosis, sarcopenia, diabetes, or neurodegenerative and cardiovascular diseases. This Special Issue welcomes contributions describing insights and approaches from all the above fields, as well as those summarizing recent advances and emerging developments. By publishing these, we hope to advance our understanding of the aging process and thereby aid the development of better strategies to prevent or mitigate negative aspects of aging, formulate targeted therapies for age-related diseases, and generally promote the well-being and healthy aging of the global population.

We look forward to your contributions.

Dr. Natascia Tiso
Dr. Giovanni Risato
Dr. Ralf Dahm
Guest Editors

Raquel Branas Casas
Guest Editor Assistant

Manuscript Submission Information

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