Experimental Systems to Model Aging Processes
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 1141
Special Issue Editors
Interests: zebrafish models; aging research; inherited diseases; heart; mitochondria; endocrine; signaling pathway
Special Issues, Collections and Topics in MDPI journals
2. Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy
Interests: zebrafish; inherited diseases; cardiomyopathy; mitochondria; signaling pathway; drug testing
Special Issue Information
Dear Colleagues,
This Special Issue of Cells on "Experimental Systems to Model Aging Processes" aims to gather contributions from internationally leading aging researchers on model systems—ranging from traditional to emerging models—used to elucidate the mechanisms underlying aging. Contributions can be in the form of original scientific articles and reviews.
Aging is driven by a range of molecular and subcellular processes, which include genetic, epigenetic, and genomic alterations; the loss of proteostasis; dysregulated autophagy; metabolic dysfunctions; or the malfunction of cellular organelles. Additionally, aging is influenced by inter-cellular dynamics, including changes in signaling pathways, inflammatory processes, and microbial balance. These events, whether individually or interconnected, can be modeled in study systems both in vitro and in vivo, as well as ex vivo and in silico.
Elucidating these processes in experimental systems—from the most reductionist to the most complex—paves the way for identifying new molecular and cellular mechanisms, as well as potential targets to mitigate the negative outcomes associated with aging, including diseases such as cancer, osteoporosis, sarcopenia, diabetes, or neurodegenerative and cardiovascular diseases. This Special Issue welcomes contributions describing insights and approaches from all the above fields, as well as those summarizing recent advances and emerging developments. By publishing these, we hope to advance our understanding of the aging process and thereby aid the development of better strategies to prevent or mitigate negative aspects of aging, formulate targeted therapies for age-related diseases, and generally promote the well-being and healthy aging of the global population.
We look forward to your contributions.
Dr. Natascia Tiso
Dr. Giovanni Risato
Dr. Ralf Dahm
Guest Editors
Raquel Branas Casas
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- ageing
- age-related
- longevity
- model
- animal
- signalling pathway
- mechanism
- in vitro
- in vivo
- cell culture
- marker
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