Autophagy in Neurological Disorders
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 73
Special Issue Editors
Interests: autophagy; neurological disorders; cancer
Interests: autophagy and protein metabolism in cancer and in neurodegeneration; epigenetics in cancer; nutraceuticals and probiotics in cancer and infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autophagy is an intracellular lysosomal degradation pathway by which cytoplasmic cargoes are removed to maintain cellular homeostasis. Dysregulation of this process is linked to loss of cell proteostasis and linked to diverse pathologies. In this Special Issue, we aim to focus on the relevance of the autophagic process in maintaining neuronal health and how it is linked to neurological disorders. Autophagy is essential in neurons and glial cells that need to cope with prolonged and sustained operational stress, and thus autophagy is known to protect against different neurological disorders, such as neuroinfectious diseases, nerve injury diseases, and neurodegenerative diseases. To tackle these pathologies, it is crucial to understand the physiological relevance of autophagy in these cells and how this pathway is linked to pathologies in the nervous system. At the same time, this research remains critical to developing biomarkers and pharmacological agents. In this Special Issue, we welcome any publication related to autophagy, either general autophagy or selective autophagy, or general loss of cell proteostasis or lysosomal-related phenotypes in these disorders. Also, any studies linking autophagy to other neurodegenerative hallmarks, such as metabolism or oxidative stress, and any studies on the effect of targeting this pathway as a therapeutic approach.
Dr. Natalia Jimenez-Moreno
Prof. Dr. Ciro Isidoro
Guest Editors
Manuscript Submission Information
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Keywords
- autophagy
- selective autophagy
- neurodegeneration
- proteostasis
- lysosomes
- aging
- oxidative stress
- aging
- biomarkers
- pharmacological agents
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