Dental Pulp Stem Cells in Human Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 25 January 2025 | Viewed by 807

Special Issue Editors


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Guest Editor
FIERCE Lab, BIOMED, UHasselt-Hasselt University, Diepenbeek, Belgium
Interests: dental pulp stem cells; oncology; peripheral neuropathies; Charcot-Marie-Tooth disease

E-Mail Website
Guest Editor
FIERCE Lab, BIOMED, UHasselt-Hasselt University, Diepenbeek, Belgium
Interests: dental pulp stem cells; Charcot-Marie-Tooth disease; nerve repair; Schwann cells; dental pulp stem cells; iPSC; animal models

E-Mail Website
Guest Editor
LISSA Lab, BIOMED, UHasselt-Hasselt University, Diepenbeek, Belgium
Interests: dental pulp stem cells; tooth organoids; angiogenesis; ischemic stroke

Special Issue Information

Dear Colleagues,

Dental pulp stem cells (DPSCs) have emerged as a promising tool in disease modeling and regenerative medicine. Found within the dental pulp, these stem cells possess the ability to differentiate into various cell types, including neural, bone, cartilage, and endothelial cells. In addition, these remarkable cells produce a wide variety of factors with beneficial results in the context of immunomodulation, inflammation, angiogenesis, etc. These unique characteristics have captured the attention of researchers and clinicians, as DPSCs offer potential therapeutic applications in a wide range of diseases and disorders.

This Special Issue will explore the use of DPSCs in several diseases and their therapeutic potential. We encourage submissions in the form of original research articles and reviews on all aspects related to the topic. Expert articles shedding light on the following topics are highly welcome: DPSC-based disease modeling, regenerative medicine, and other therapeutic approaches.

Prof. Dr. Esther Wolfs
Dr. Tim Vangansewinkel
Dr. Annelies Bronckaers
Guest Editors

Manuscript Submission Information

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Keywords

  • dental pulp stem cells
  • disease
  • regenerative medicine
  • disease modeling

Published Papers (1 paper)

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Research

19 pages, 2441 KiB  
Article
Dental Pulp Stem Cells Modulate Inflammasome Pathway and Collagen Deposition of Dermal Fibroblasts
by Giada Zanini, Giulia Bertani, Rosanna Di Tinco, Alessandra Pisciotta, Laura Bertoni, Valentina Selleri, Luigi Generali, Alessandra Marconi, Anna Vittoria Mattioli, Marcello Pinti, Gianluca Carnevale and Milena Nasi
Cells 2024, 13(10), 836; https://doi.org/10.3390/cells13100836 - 14 May 2024
Viewed by 557
Abstract
Fibrosis is a pathological condition consisting of a delayed deposition and remodeling of the extracellular matrix (ECM) by fibroblasts. This deregulation is mostly triggered by a chronic stimulus mediated by pro-inflammatory cytokines, such as TNF-α and IL-1, which activate fibroblasts. Due to their [...] Read more.
Fibrosis is a pathological condition consisting of a delayed deposition and remodeling of the extracellular matrix (ECM) by fibroblasts. This deregulation is mostly triggered by a chronic stimulus mediated by pro-inflammatory cytokines, such as TNF-α and IL-1, which activate fibroblasts. Due to their anti-inflammatory and immunosuppressive potential, dental pulp stem cells (DPSCs) could affect fibrotic processes. This study aims to clarify if DPSCs can affect fibroblast activation and modulate collagen deposition. We set up a transwell co-culture system, where DPSCs were seeded above the monolayer of fibroblasts and stimulated with LPS or a combination of TNF-α and IL-1β and quantified a set of genes involved in inflammasome activation or ECM deposition. Cytokines-stimulated co-cultured fibroblasts, compared to unstimulated ones, showed a significant increase in the expression of IL-1β, IL-6, NAIP, AIM2, CASP1, FN1, and TGF-β genes. At the protein level, IL-1β and IL-6 release as well as FN1 were increased in stimulated, co-cultured fibroblasts. Moreover, we found a significant increase of MMP-9 production, suggesting a role of DPSCs in ECM remodeling. Our data seem to suggest a crosstalk between cultured fibroblasts and DPSCs, which seems to modulate genes involved in inflammasome activation, ECM deposition, wound healing, and fibrosis. Full article
(This article belongs to the Special Issue Dental Pulp Stem Cells in Human Disease)
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