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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mechanism of Endocrine Therapy Resistance in Breast Cancer

edited by

Debra A. Tonetti

and Clodia Osipo

submission deadline 1 May 2026 | Viewed by 34 | Submission Open

Keywords: estrogen receptor; endocrine resistance; mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings

(This special issue belongs to the Section Cellular Pathology)

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 10 May 2026 | Viewed by 510 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer

edited by

Yongye Huang

, Lin Yuan and Yang Yu

submission deadline 10 May 2026 | Viewed by 122 | Submission Open

Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics

Retinal Disorders: Cellular Mechanisms and Targeted Therapies

edited by

Takeshi Iwata

submission deadline 15 May 2026 | 5 articles | Viewed by 10726 | Submission Open

Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics

(This special issue belongs to the Section Cellular Pathology)

Placenta in Tissue Engineering and Regeneration

edited by

Gayathri Rajaraman

submission deadline 15 May 2026 | Viewed by 199 | Submission Open

Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration

Molecular and Translational Advances in Metastatic Breast Cancer Research

edited by

Sravani Ramisetty

submission deadline 15 May 2026 | Viewed by 107 | Submission Open

Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis

The Role of Light in Ocular Health and Disease

edited by Krisztina Valter,

María Ana Contín

and

Monica Acosta

submission deadline 15 May 2026 | Viewed by 84 | Submission Open

Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics

Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition

edited by

Mehrnoosh Saghizadeh Ghiam

and

Vivien Coulson-Thomas

submission deadline 20 May 2026 | 6 articles | Viewed by 7986 | Submission Open

Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β

(This special issue belongs to the Section Cell Signaling)

Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery

edited by Roberta Montanari and

Alberto Vitali

submission deadline 20 May 2026 | 1 articles | Viewed by 2551 | Submission Open

Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms

(This special issue belongs to the Section Cellular Biophysics)

Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease

edited by

Israël Vlodavsky

and

Jin-Ping Li

submission deadline 20 May 2026 | 1 articles | Viewed by 1581 | Submission Open

Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation

(This special issue belongs to the Section Cell Signaling)

The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses

edited by

Dimitrios Vlachakis

Tassos Georgakopoulos

and

Marios Agelopoulos

submission deadline 20 May 2026 | 2 articles | Viewed by 1442 | Submission Open

Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications

(This special issue belongs to the Section Cellular Pathology)

The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation

edited by

Vinay Shukla

submission deadline 20 May 2026 | 1 articles | Viewed by 1321 | Submission Open

Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation

(This special issue belongs to the Section Tissues and Organs)

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 20 May 2026 | Viewed by 225 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 20 May 2026 | Viewed by 158 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

(This special issue belongs to the Section Cell Microenvironment)

Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine

edited by Emanuela Mari

submission deadline 20 May 2026 | Viewed by 48 | Submission Open

Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome

(This special issue belongs to the Section Stem Cells)

Cellular and Molecular Basis of Sjögren’s Syndrome

edited by Muhammad Shahnawaz Soyfoo

submission deadline 20 May 2026 | Viewed by 36 | Submission Open

Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity

Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies

edited by Jayakumar R. Nair

submission deadline 20 May 2026 | Viewed by 32 | Submission Open

Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity

(This special issue belongs to the Section Cellular Pathology)

Regulation of Iron Homeostasis

edited by

Huangen Ding

submission deadline 20 May 2026 | Viewed by 28 | Submission Open

Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins

Pathology and Therapies in Brain Tumor

edited by Bachuchu Lal

submission deadline 20 May 2026 | Viewed by 25 | Submission Open

Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models

(This special issue belongs to the Section Cellular Pathology)

Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition

edited by

Dimitrios Kouroupis

and

Thomas M. Best

submission deadline 25 May 2026 | 2 articles | Viewed by 3623 | Submission Open

Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering

(This special issue belongs to the Section Stem Cells)

Cell Therapy for Retinal Diseases

edited by

Girish Kumar Srivastava

and

Yogeswaran Lokanathan

submission deadline 25 May 2026 | Viewed by 388 | Submission Open

Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration

(This special issue belongs to the Section Tissues and Organs)

Cell Signaling in Neurodegeneration Disease

edited by

Rijwan Uddin Ahammad

, Yasuhiro Funahashi,

Akira Sobue

Xinjian Zhang

and Md-nadim Hossain

submission deadline 25 May 2026 | Viewed by 287 | Submission Open

Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience

(This special issue belongs to the Section Cells of the Nervous System)

Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury

edited by

Daniel J. Hellenbrand

and Angela R. Filous

submission deadline 25 May 2026 | Viewed by 150 | Submission Open

Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia

Metabolic Regulation of Cell Behavior and Implications for Aging

edited by

Eloy Bejarano

and José Antonio Rodríguez Navarro

submission deadline 25 May 2026 | Viewed by 80 | Submission Open

Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy

Cellular and Molecular Insights into Female Reproductive Biology

edited by

Mohamed Ali

submission deadline 25 May 2026 | Viewed by 68 | Submission Open

Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis

(This special issue belongs to the Section Reproductive Cells and Development)

Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy

edited by

Ali R. Jazirehi

submission deadline 25 May 2026 | Viewed by 42 | Submission Open

Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis

Brain Function and Structure: Mapping Complexity in Neuronal Cells

edited by

José Antonio Del Río Fernández

submission deadline 25 May 2026 | Viewed by 37 | Submission Open

Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience

From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies

edited by

Francesca Bianchi

Elena Dozio

and

Lucia La Sala

submission deadline 29 May 2026 | Viewed by 235 | Submission Open

Keywords: obesity; inflammasomes; immune system; microbiota

(This special issue belongs to the Section Tissues and Organs)

Therapeutic Targeting of Myeloid Cells in Tumor

edited by Mirko Farina and

Giovanni Micheloni

submission deadline 30 May 2026 | Viewed by 46 | Submission Open

Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development

Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance

edited by

Katrina F. Cooper

and Kleiton Silva

submission deadline 30 May 2026 | Viewed by 13 | Submission Open

Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders

(This special issue belongs to the Section Autophagy)

Proteomic Applications in Ageing and Neurodegenerative Conditions

edited by

Thomas Wishart

Rachel A. Kline

and

Dominic Kurian

submission deadline 31 May 2026 | 4 articles | Viewed by 18580 | Submission Open

(This special issue belongs to the Section Cell Methods)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 May 2026 | 8 articles | Viewed by 18533 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cells of the Nervous System)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 31 May 2026 | 5 articles | Viewed by 12591 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition

edited by

Hideki Sudo

submission deadline 31 May 2026 | 4 articles | Viewed by 11271 | Submission Open

Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy

(This special issue belongs to the Section Cellular Pathology)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 May 2026 | 2 articles | Viewed by 5262 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 May 2026 | 3 articles | Viewed by 3731 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cells of the Nervous System)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 May 2026 | 2 articles | Viewed by 3159 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research

edited by

Elena Coccia

submission deadline 31 May 2026 | 1 articles | Viewed by 2697 | Submission Open

Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine

(This special issue belongs to the Section Stem Cells)

The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function

edited by

Alessandra Maria Vitale

and Federica Scalia

submission deadline 31 May 2026 | 1 articles | Viewed by 1554 | Submission Open

Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches

G Protein-Coupled Receptors and Diseases

edited by

Yongqiang Chen

submission deadline 31 May 2026 | Viewed by 616 | Submission Open

Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation

Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity

edited by Jiabei Lin

submission deadline 31 May 2026 | 1 articles | Viewed by 611 | Submission Open

Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 31 May 2026 | Viewed by 390 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics

edited by

Roshanak Rahimian

and

Mitra Esfandiarei

submission deadline 31 May 2026 | Viewed by 163 | Submission Open

Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat and Grzegorz Turek

submission deadline 31 May 2026 | Viewed by 162 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 31 May 2026 | Viewed by 150 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cells of the Nervous System)

Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis

edited by

Qianman Peng

and Jianzhong Shen

submission deadline 31 May 2026 | Viewed by 148 | Submission Open

Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling

Development and Characterization of Innovative In Vitro Models

edited by Fengyan Deng and Chongbei Zhao

submission deadline 31 May 2026 | Viewed by 136 | Submission Open

Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling

Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis

edited by

Pan Ma

submission deadline 31 May 2026 | Viewed by 102 | Submission Open

Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics

Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression

edited by

Kunzhe Dong

and

Liming Yu

submission deadline 31 May 2026 | Viewed by 94 | Submission Open

Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition

(This special issue belongs to the Section Cells of the Cardiovascular System)

Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation

edited by

Nima Azari-Dolatabad

and Osvaldo Bogado Pascottini

submission deadline 31 May 2026 | Viewed by 93 | Submission Open

Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling

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