Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 28 November 2025 | Viewed by 257

Special Issue Editor


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Guest Editor
College of Veterinary Medicine, University of Missouri at Columbia, Columbia, MO 65211, USA
Interests: molecular genetics; neuron biology, including neurodegeneration and neuron regeneration; spinal muscular atrophy (SMA); amyotrophic lateral sclerosis (ALS); Alzheimer’s disease (AD); transcription-coupled R-loops; DNA damage and repair; RNA biogenesis; molecular and translational medicine; genetically modified yeast models; mouse models of neurological diseases
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Special Issue Information

Dear Colleagues,

This Special Issue focuses on amyotrophic lateral sclerosis (ALS), a serious neuromuscular disease that affects nerve cells in the brain and the spinal cord, leading to muscle weakness, disability, and death. This Special Issue aims to gather research on the latest findings in the pathology of ALS, including studies on how the disease develops, its effects on the body, and the molecular mechanisms of disease pathogenesis. It also seeks to highlight new and existing treatments that can help manage symptoms and improve quality of life for patients.

Researchers and experts are invited to submit papers that explore various aspects of ALS, including its biological mechanisms, risk factors, diagnostic tools, and innovative treatment methods. We welcome studies that examine basic laboratory findings and reviews that summarize current knowledge in the field. The goal is to create a comprehensive collection of work that enhances our understanding and guides future research and treatment strategies for ALS.

All submissions should adhere to Cells’ guidelines and should be submitted by the deadline. We look forward to your contributions to this important field of study.

Prof. Dr. Laxman Gangwani
Guest Editor

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Keywords

  • amyotrophic lateral sclerosis (ALS)
  • pathology
  • molecular mechanisms
  • treatments
  • symptom management
  • biological mechanisms
  • risk factors
  • innovative treatments

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Published Papers (1 paper)

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Review

13 pages, 940 KiB  
Review
Management of Dysarthria in Amyotrophic Lateral Sclerosis
by Elena Pasqualucci, Diletta Angeletti, Pamela Rosso, Elena Fico, Federica Zoccali, Paola Tirassa, Armando De Virgilio, Marco de Vincentiis and Cinzia Severini
Cells 2025, 14(14), 1048; https://doi.org/10.3390/cells14141048 - 9 Jul 2025
Viewed by 95
Abstract
Amyotrophic lateral sclerosis (ALS) stands as the leading neurodegenerative disorder affecting the motor system. One of the hallmarks of ALS, especially its bulbar form, is dysarthria, which significantly impairs the quality of life of ALS patients. This review provides a comprehensive overview of [...] Read more.
Amyotrophic lateral sclerosis (ALS) stands as the leading neurodegenerative disorder affecting the motor system. One of the hallmarks of ALS, especially its bulbar form, is dysarthria, which significantly impairs the quality of life of ALS patients. This review provides a comprehensive overview of the current knowledge on the clinical manifestations, diagnostic differentiation, underlying mechanisms, diagnostic tools, and therapeutic strategies for the treatment of dysarthria in ALS. We update on the most promising digital speech biomarkers of ALS that are critical for early and differential diagnosis. Advances in artificial intelligence and digital speech processing have transformed the analysis of speech patterns, and offer the opportunity to start therapy early to improve vocal function, as speech rate appears to decline significantly before the diagnosis of ALS is confirmed. In addition, we discuss the impact of interventions that can improve vocal function and quality of life for patients, such as compensatory speech techniques, surgical options, improving lung function and respiratory muscle strength, and percutaneous dilated tracheostomy, possibly with adjunctive therapies to treat respiratory insufficiency, and finally assistive devices for alternative communication. Full article
(This article belongs to the Special Issue Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS))
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