Mitochondrial Dynamics and Remodelling
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 June 2026 | Viewed by 84
Special Issue Editor
Interests: immunology; mitochondria research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondrial dynamics govern the balance between fission, fusion, motility, and selective turnover, shaping cell fate. These processes rely on dynamin-related GTPases, cristae-structuring complexes, and quality-control mechanisms including mitophagy and mitochondrial-derived vesicles. Their coordination is further integrated with ER–mitochondria contact sites, cytoskeletal transport, and signaling pathways that adjust mitochondrial morphology to cellular needs. Key questions remain unresolved: how distinct cell types (neurons, cardiomyocytes, immune cells) establish specific fission–fusion set points, how lipids and post-translational modifications regulate rapid remodeling under stress, and how cristae changes intersect with bioenergetics in neurodegeneration, cancer, and metabolic disorders. Moreover, it is unclear which roles of quality control are causal versus compensatory in disease. Advances in live-cell imaging, cryo-electron tomography, spatial omics, and genetically encoded reporters have provided new insights, but spatiotemporal integration of these processes is still required. This Special Issue aims to synthesize current understanding of mitochondrial structural machines (DRP1, MFF, FIS1, OPA1, MFN1/2, MICOS), signaling hubs (AMPK, mTORC1/2, Ca2+/calcineurin), and their links to bioenergetics, immune function, and disease. We highlight therapeutic opportunities through small-molecule modulators, gene-based interventions, and strategies to restore mitochondrial remodeling in health and pathology.
Dr. Edmund Carvalho
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrial dynamics
- fission
- fusion
- mitophagy
- cristae remodeling
- bioenergetics
- ER–mitochondria contacts
- immune reprogramming
- signaling pathways
- therapeutic targeting
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
