Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 November 2025 | Viewed by 48
Special Issue Editor
Interests: myocardial infarction; heart failure; cardiac metabolism; mitochondria; cardioprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
I am pleased to invite contributions that address one of the most urgent challenges in cardiovascular medicine: preventing heart failure following acute myocardial infarction (AMI). Despite advances in pharmacological therapies and interventional cardiology, heart failure remains a leading cause of long-term morbidity and mortality among AMI survivors. A major contributor to this outcome is ischemia–reperfusion (I/R) injury, an event that paradoxically exacerbates heart damage when blood flow is restored.
This Special Issue aims to spotlight recent breakthroughs in understanding the cellular and molecular mechanisms driving I/R injury and heart failure, focusing on mitochondria, inflammation, and metabolic remodeling. We aim to showcase innovative therapeutic strategies that have the potential to move from bench to bedside and ultimately improve patient outcomes.
We welcome original research articles, comprehensive reviews, expert perspectives investigating cellular mechanisms of I/R injury, novel molecular targets, innovative therapeutic strategies, and translational approaches in the context of myocardial infarction and heart failure.
Suggested topics include but are not limited to the following:
- Mitochondrial dynamics and cardioprotection;
- New insights into inflammation and oxidative stress in I/R injury;
- Emerging small molecules and peptides for cardioprotection;
- Cell-based therapies and regenerative medicine in AMI;
- Exosomes and extracellular vesicles therapies;
- Nanomedicine and targeted drug delivery in cardiovascular therapy;
- Artificial intelligence and applications in I/R research.
Dr. Sauri Hernandez-Resendiz
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- myocardial infarction
- heart failure
- ischemia/reperfusion injury
- no-reflow phenomenon
- oxidative stress
- cell death
- cardiac metabolism
- mitochondrial quality control
- inflammation
- cardioprotection
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