AMPK: From Mechanisms to New Therapies
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 December 2025 | Viewed by 15
Special Issue Editors
Interests: placenta growth factor; pregnancy toxemia; endoglin
Special Issue Information
Dear Colleagues,
AMP-activated protein kinase (AMPK) has emerged as a central regulator of cellular energy homeostasis and a key modulator of various physiological and pathological processes. Its role is highly context-dependent, varying with tissue type, metabolic status, and disease condition. Understanding how AMPK functions in different biological systems and how its signaling pathways become dysregulated is essential for developing targeted therapeutic strategies.
This Special Issue will explore the multifaceted roles of AMPK in health and disease. Topics will include its involvement in metabolic disorders such as type 2 diabetes and obesity, where AMPK activation enhances insulin sensitivity and glucose uptake; in cancer, where it influences cell proliferation, metabolism, and the tumor microenvironment; and in reproductive health, particularly placenta-related pathologies and male fertility, where it regulates energy balance, nutrient transport, and sperm function. We will also highlight the role of AMPK in skin health, including aging, inflammation, and barrier dysfunction, and its broader implications in stress responses and cellular adaptation.
We welcome original research articles, reviews, and communications that provide new insights into the regulatory mechanisms, physiological functions, and translational applications of AMPK in health and disease. The aim of this Special Issue is to provide a comprehensive overview of current advances in AMPK biology, from molecular mechanisms and regulatory networks to novel therapeutic strategies.
By submitting to this Special Issue, authors will gain visibility in a community of researchers focused on AMPK. It is a great opportunity to share your latest findings, help shape the future of AMPK research, and connect with others interested in new ideas and discoveries. This issue offers a unique chance to highlight your work, encourage collaborations, and contribute to the link between basic science and clinical applications.
Dr. Roland Abi Nahed
Dr. Farah Diab
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolism
- AMPK
- cancer
- biosensors
- reproduction
- metabolic disorders
- therapies
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