Role of Calpains in Health and Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 305
Special Issue Editors
Interests: mechanisms implicated in long-term synaptic potentiation and depression in hippocampus and other brain regions; regulation of glutamate receptors; role of oxygen free radicals in central nervous system; mechanisms underlying selective neuronal degeneration; computational neuroscience
Special Issue Information
Dear Colleagues,
Calpains comprise a large family of proteases that are tremendously conserved amongst species and are ubiquitously distributed in tissues. Since their discovery, there has been remarkable progress in understanding their diversity, structure, physiological roles, and involvement in a number of diseases. Today, more than 7,000 research articles focus on the calpains. Because of the increasing relevance of calpains to diseases such as eye diseases, neurodegeneration, muscle and metabolic diseases, wound healing, gastrointestinal disease, inflammation, and cancer, the field is continuously expanding. This Special Issue of Cells will provide the latest findings regarding the mechanisms underlying the roles of calpains in cell functions, the roles of different calpains under physiological and pathological conditions, as well as the translation of these findings into novel therapeutic approaches for several disorders. In addition, genetic studies are indicating that mutations in several calpains play critical roles in the etiology of several diseases, further extending the relevance of calpains in health and diseases.
Dr. Michel Baudry
Dr. Peter A. Greer
Guest Editors
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Keywords
- calpain
- physiology
- biochemistry
- disease
- mutation
- target
- inhibitor
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