The Immunology of Allergy and Asthma
Special Issue Editor
2. Department of Pneumology, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium
Interests: mucosal immunology; respiratory medicine; allergy and pulmonary diseases; IgA; lung epithelium biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The skin, the airway and gut mucosae are directly exposed to external matters. This environmental pressure represents a challenge for skin and mucosal epithelial barriers, as well as the immune system, to prevent unnecessary responses and to adapt their response to noxious or harmless exposures. Homeostasis in the skin and mucosal barriers involves a complex interplay between structural and immune cells, while their dysregulation may lead to chronic immune activation leading to epithelium damage, tissue remodeling and ultimately organ dysfunction. This scenario that is seen in different phenotypes of rhinitis/sinusitis, asthma, food allergy or dermatitis is eventually driven or accompanied by the production of allergen-specific IgE antibodies following certain cognate interactions between dendritic cells and T-helper cells that trigger B-cell switching to this unique antibody class. While the distinction between IgE-mediated, allergic and non-specific inflammatory conditions in the aforementioned organs still represents an urgent step in both clinical management and basic immunology, type 2 immune activation has emerged as a dominating immune background trait that can be targeted by available biological therapies. Fundamental mechanisms orchestrating both type 2 or non-type 2 immune cell activation as well as IgE production should be further delineated in order to prevent disease in genetically at-risk individuals or to induce remission in affected patients. In addition, the mechanisms of acute non-specific reactivity to certain food or drug triggers that involve mast cells should also be characterized. Furthermore, the role of structural cells and host–microbiome interactions should be further studied to unravel novel mechanisms and to provide innovative therapeutic strategies.
Prof. Dr. Charles Pilette
Guest Editor
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Keywords
- type 2 immunity
- rhinitis
- food allergy
- anaphylaxis
- drug allergy
- dermatitis
- eczema
- airway inflammation
- IgE response
- tissue remodelling
- disease remission
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