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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ischemic Heart Disease: From Cellular Level to Clinical Approaches

edited by

Stefan A. Juričić

and

Milan R. Dobrić

submission deadline 25 Mar 2026 | 1 articles | Viewed by 439 | Submission Open

Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy

Gene Editing Therapies for Hereditary Diseases

edited by

Jacques P. Tremblay

submission deadline 25 Mar 2026 | Viewed by 263 | Submission Open

Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases

(This special issue belongs to the Section Cell and Gene Therapy)

Cell and Molecular Mechanisms of Bacterial Meningitis

edited by

Lars Ove Brandenburg

submission deadline 25 Mar 2026 | Viewed by 152 | Submission Open

Keywords: bacterial meningitis; innate immunity; inflammation; immune response; central nervous system; neuron; microglia; astrocytes; granulocytes; blood– brain barrier

Mitochondria: Multifaceted Regulators of Cell Death

edited by Rasa Banienė and Sonata Trumbeckaite

submission deadline 25 Mar 2026 | Viewed by 147 | Submission Open

Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer

From Signals to Shape: Molecular Control of Cellular Plasticity Through Epigenetic, Transcriptomic, and Immune Mechanisms

edited by

Ines Schoberleitner

and

Salvatore Fusco

submission deadline 25 Mar 2026 | Viewed by 142 | Submission Open

Keywords: cellular plasticity; epigenetics; transcriptomics; mechanotransduction; immune signaling; cell fate regulation; RNA methylation; biomaterials interaction; molecular cytology; cell adaptation

Cancer Stem Cells in Triple-Negative Breast Cancer

edited by

Antonella Zannetti

and

Maria Grazia Caprio

submission deadline 25 Mar 2026 | Viewed by 118 | Submission Open

Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers

Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration

edited by

Zhaoyu Li

submission deadline 25 Mar 2026 | Viewed by 116 | Submission Open

Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control

Molecular Mechanisms of Trophoblast Differentiation

edited by Milica Jovanović Krivokuća and

Jianjun Wei

submission deadline 25 Mar 2026 | Viewed by 113 | Submission Open

Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation

Biomarkers and Therapeutic Targets in Insulin Resistance

edited by

Mohamed Elrayess

submission deadline 30 Mar 2026 | 1 articles | Viewed by 2381 | Submission Open

Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases

(This special issue belongs to the Section Cellular Pathology)

Neuroimaging of Cerebrovascular Diseases

edited by Dragan Stojanov

submission deadline 30 Mar 2026 | Viewed by 185 | Submission Open

Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI

Mechanisms of miRNA Metabolism and Extracellular Transport

edited by

Suvendra N Bhattacharyya

submission deadline 30 Mar 2026 | Viewed by 175 | Submission Open

Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers

Novel Insights into Cancer Immune Responsiveness

edited by

Luigi Racioppi

and

Tanmoy Mondal

submission deadline 30 Mar 2026 | Viewed by 149 | Submission Open

Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Mar 2026 | Viewed by 127 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment

edited by

Mohd Ahmar Rauf

submission deadline 30 Mar 2026 | Viewed by 115 | Submission Open

Keywords: tumor microenvironment; drug delivery; nanoparticle

(This special issue belongs to the Section Cell Methods)

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and

Hami Hemati

submission deadline 30 Mar 2026 | Viewed by 114 | Submission Open

Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells

Cellular and Molecular Mechanisms of Cardiomyopathy

edited by

Zaglia Tania

and

Maurizio Forte

submission deadline 30 Mar 2026 | Viewed by 107 | Submission Open

Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis

(This special issue belongs to the Section Tissues and Organs)

Molecular Mechanisms and Biomarker Development in Prostate Cancer

edited by Vikas Mehta and Behtash Ghazi Nezami

submission deadline 30 Mar 2026 | Viewed by 80 | Submission Open

Keywords: androgen receptor; prostate molecular alterations; biomarkers

Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders

edited by

Györgyi Műzes

and

Ferenc Sipos

submission deadline 31 Mar 2026 | 5 articles | Viewed by 24464 | Submission Open

Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections

(This special issue belongs to the Section Cellular Immunology)

Flow Cytometry in Immunology Research

edited by

Ziv Porat

and Ekaterina Kopitman

submission deadline 31 Mar 2026 | 3 articles | Viewed by 12995 | Submission Open

Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays

(This special issue belongs to the Section Cell Methods)

Organoids and Models from Stem Cells

edited by Tiziana A. L. Brevini and

Georgia Pennarossa

submission deadline 31 Mar 2026 | 3 articles | Viewed by 7710 | Submission Open

Keywords: cellular microenvironment; 3D culture; organoid

(This special issue belongs to the Section Stem Cells)

mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact

edited by

Stefano Zoroddu

and

Luigi M. Bagella

submission deadline 31 Mar 2026 | 3 articles | Viewed by 5905 | Submission Open

Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems

(This special issue belongs to the Section Cellular Pathology)

Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

edited by Yuxiang Xie and Jingqi Yan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3922 | Submission Open

Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies

(This special issue belongs to the Section Cells of the Nervous System)

Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses

edited by Nianli Sang

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3811 | Submission Open

Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis

(This special issue belongs to the Section Cell Signaling)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3148 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Drosophila as a Model for Understanding Human Disease

edited by Zhe Han

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2860 | Submission Open

Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research

(This special issue belongs to the Section Cellular Pathology)

Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease

edited by

Alexander E. Berezin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2301 | Submission Open

Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management

(This special issue belongs to the Section Tissues and Organs)

Molecular Insights into Vascular Physiology and Pathology

edited by Suravi Majumder

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1935 | Submission Open

Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies

edited by

Rengasamy Balakrishnan

and

Balamuralikrishnan Balasubramanian

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1450 | Submission Open

Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex

edited by

Ángel A. Núñez

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1435 | Submission Open

Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors

(This special issue belongs to the Section Cells of the Nervous System)

From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria

edited by Amy H. Attaway and Saurabh Mishra

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1221 | Submission Open

Keywords: mitochondrial oxidation; ROS; aging; disease

Cellular Mechanisms in Pregnancy and Foetal Development

edited by

Anya L. Arthurs

and

Giovanni Levi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1171 | Submission Open

Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth

The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine

edited by

Lucie Bacakova

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1136 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering

The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

edited by

Silvia Peppicelli

and Giulio Menegazzi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 715 | Submission Open

Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Insights into Allergies and Allergic Diseases

edited by

Toshiaki Kawakami

submission deadline 31 Mar 2026 | Viewed by 304 | Submission Open

Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 31 Mar 2026 | Viewed by 292 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 31 Mar 2026 | Viewed by 268 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease

edited by Praveen Koganti and

Michal Goldberg

submission deadline 31 Mar 2026 | Viewed by 223 | Submission Open

Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 31 Mar 2026 | Viewed by 219 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics

edited by

Jonathan Barra

submission deadline 31 Mar 2026 | Viewed by 203 | Submission Open

Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis

Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration

edited by Mukund Srinivasan

submission deadline 31 Mar 2026 | Viewed by 203 | Submission Open

Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 31 Mar 2026 | Viewed by 189 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Neurodegenerative Diseases and Related Proteins

edited by Tian Liu

submission deadline 31 Mar 2026 | Viewed by 188 | Submission Open

Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 31 Mar 2026 | Viewed by 188 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities

edited by

Sherri R. Cervantes

and

Daruka Mahadevan

submission deadline 31 Mar 2026 | Viewed by 179 | Submission Open

Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer

(This special issue belongs to the Section Cell Microenvironment)

Therapeutic Targeting of MicroRNAs in Human Cancer

edited by

Behzad Mansoori

submission deadline 31 Mar 2026 | Viewed by 178 | Submission Open

Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies

(This special issue belongs to the Section Cell and Gene Therapy)

Advances in CAR Cell Therapies and Manufacturing

edited by William J. Kelly and Madhuresh C. Sumit

submission deadline 31 Mar 2026 | Viewed by 174 | Submission Open

Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Mar 2026 | Viewed by 169 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition

edited by

Jean Christopher Chamcheu

Claudia Bürger

and

Shile Huang

submission deadline 31 Mar 2026 | Viewed by 167 | Submission Open

Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 31 Mar 2026 | Viewed by 164 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death

(This special issue belongs to the Section Cells of the Nervous System)

GABA_A Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms

edited by Tingwei Mu and Yajuan Wang

submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open

Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms

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