Mechanisms Underlying Cell Growth and Development

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 October 2025 | Viewed by 552

Special Issue Editor


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Guest Editor
Laboratory of Cell Biology and Electron Microscopy, Faculty of Medicine, University of Tours, 10, Boulevard Tonnelle, 37032 Tours, France
Interests: cell differentiation; cell division; centrosome; centriole; cilia; flagella; cytoskeleton; mitosis; cell cycle
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Special Issue Information

Dear Colleagues,

All living cells undergo growth and reproduction during specific periods of their life cycle. Following differentiation, these processes often cease; however, to maintain cellular function, cells continuously renew their organelles. These processes are governed by the activation or inhibition of hundreds to thousands of genes and the intricate interactions among numerous cellular proteins. Despite the shared genetic background across each cell of an organism, the structures and developmental fates of cells are so different that, without knowledge of their common origin, it would be possible to assume that they were genetically diverse. The pathways behind cell differentiation are influenced by various factors, primarily, the specific cellular microenvironment and the presence of certain signaling molecules that act upon a cell. 

This Special Issue of the journal Cells will present a collection of articles focusing on the mechanisms underlying cell development, growth, and differentiation. Contributions will explore how molecular rearrangements alter cell structure and drive morphological transformations, providing new insights into the complex processes that shape cellular identity and function. 

Dr. Rustem E. Uzbekov
Guest Editor

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Keywords

  • cell growth
  • cell development
  • cell differentiation
  • cell cycle
  • mitosis
  • meiosis
  • molecular rearrangements
  • chromosomes
  • gene expression

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Published Papers (1 paper)

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Research

12 pages, 2505 KiB  
Article
The Expression of Shmt Genes in Amphioxus Suggests a Role in Tissue Proliferation Rather than in Neurotransmission
by Matteo Bozzo, Emanuele Serafini, Giacomo Rosa, Virginia Bazzurro, Andrea Amaroli, Sara Ferrando, Michael Schubert and Simona Candiani
Cells 2025, 14(14), 1071; https://doi.org/10.3390/cells14141071 - 13 Jul 2025
Viewed by 393
Abstract
Serine hydroxymethyltransferases (SHMTs) are key enzymes in one-carbon metabolism, with vertebrates possessing two paralogs, cytosolic SHMT1 and mitochondrial SHMT2, implicated in nucleotide biosynthesis and glycine metabolism. In this study, we investigate the evolutionary history of animal Shmt genes and analyze the expression patterns [...] Read more.
Serine hydroxymethyltransferases (SHMTs) are key enzymes in one-carbon metabolism, with vertebrates possessing two paralogs, cytosolic SHMT1 and mitochondrial SHMT2, implicated in nucleotide biosynthesis and glycine metabolism. In this study, we investigate the evolutionary history of animal Shmt genes and analyze the expression patterns of Shmt genes in developing amphioxus (Branchiostoma lanceolatum). Phylogenetic analyses indicate the presence of Shmt1 and Shmt2 orthologs in deuterostomes, spiralians and placozoans, which is consistent with an ancient Shmt gene duplication event predating bilaterian diversification. Gene expression analyses in developing amphioxus show that Shmt2 expression is confined to the somites and absent from neural tissues. In contrast, Shmt1 is broadly expressed across germ layers, but its transcription is restricted to tissues characterized by strong cell proliferation. Notably, Shmt1 expression in the nervous system does not match the distribution of glycinergic neuron populations, implying a negligible role in glycine neurotransmitter synthesis. Instead, the spatial correlation of Shmt1 expression with mitotically active domains suggests a primary function in nucleotide biosynthesis via one-carbon metabolism. These findings indicate that SHMTs predominantly support cell proliferation rather than neurotransmission in amphioxus. Full article
(This article belongs to the Special Issue Mechanisms Underlying Cell Growth and Development)
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