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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Jun 2026 | Viewed by 152 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cellular Neuroscience)

Metabolic Reprogramming in Organ Fibrosis and Regeneration

edited by Melanie Tran and Dong Yang

submission deadline 20 Jun 2026 | Viewed by 60 | Submission Open

Keywords: metabolic reprogramming; fibrosis; tissue regeneration; cellular metabolism; mitochondrial dysfunction; tissue repair and remodeling

(This special issue belongs to the Section Cellular Metabolism)

Molecular and Cellular Mechanisms of Insulin Secretion

edited by

Haiqiang Dou

submission deadline 20 Jun 2026 | Viewed by 46 | Submission Open

Keywords: insulin secretion; beta-cells; pancreatic islets; diabetes; exocytosis; Ca2+

(This special issue belongs to the Section Cellular Metabolism)

The Orchestration of Glial Cells in Health and Disease

edited by Keying Zhu

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1498 | Submission Open

Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 25 Jun 2026 | Viewed by 420 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Jun 2026 | Viewed by 266 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

The Function of Stem Cells in the Biomedical Applications

edited by Rakesh Kumar Srivastava

submission deadline 25 Jun 2026 | Viewed by 88 | Submission Open

Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery

Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies

edited by Kjell Heuser and

Cecilie Nome

submission deadline 25 Jun 2026 | Viewed by 84 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication

Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration

edited by Soung-Hoon Lee

submission deadline 25 Jun 2026 | Viewed by 73 | Submission Open

Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology

Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics

edited by Muhammad Soyfoo

submission deadline 25 Jun 2026 | Viewed by 57 | Submission Open

Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease

Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities

edited by Victoria McGilligan

submission deadline 25 Jun 2026 | Viewed by 46 | Submission Open

Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics

The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment

edited by

Elisa Tonoli

and

Elisabetta Verderio Edwards

submission deadline 25 Jun 2026 | Viewed by 29 | Submission Open

Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 30 Jun 2026 | 8 articles | Viewed by 38199 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 30 Jun 2026 | 7 articles | Viewed by 12970 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 30 Jun 2026 | 2 articles | Viewed by 10980 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Jun 2026 | 5 articles | Viewed by 8343 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5945 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5689 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5628 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Study on Immune Activity of Natural Products

edited by Xiu-Min Li

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3192 | Submission Open

Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential

MicroRNAs: Regulators of Cellular Fate

edited by

Hsiuying Wang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2142 | Submission Open

Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker

The Role of T Cells and Cellular Signalling in Immune Diseases

edited by Daniela Gallo

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1410 | Submission Open

Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies

(This special issue belongs to the Section Cellular Immunology)

Emerging Topics in Cachexia

edited by Gabriela Salim Ferreira De Castro

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1214 | Submission Open

Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 30 Jun 2026 | 2 articles | Viewed by 994 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Jun 2026 | 1 articles | Viewed by 805 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

Extracellular Vesicles and Cell Therapies in Regenerative Nephrology and Urology

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 30 Jun 2026 | 1 articles | Viewed by 715 | Submission Open

Keywords: extracellular vesicles (EVs); microRNA (miRNA); acute kidney injury (AKI); chronic kidney disease (CKD); glomerulonephritis; kidney transplantation; fibrosis; mesenchymal stromal cells (MSCs); engineered EVs; single-cell and spatial omics; machine learning and artificial intelligence; ; precision nephrology; GMP manufacturing; regenerative medicine; biomarkers; artificial intelligence (AI)

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms in Gastrointestinal Diseases

edited by

Shakti Ranjan Satapathy

and

Vikas Yadav

submission deadline 30 Jun 2026 | Viewed by 519 | Submission Open

Keywords: gastrointestinal pathophysiology ; epithelial– mesenchymal transition (EMT) ; inflammation and immune regulation ; tumor microenvironment ; cell signaling pathways ; stem cell biology in GI tract ; molecular biomarkers ; organoids and disease modeling ; microbiome– host interactions ; drug discovery

(This special issue belongs to the Section Tissues and Organs)

Retinoic Acid and Retinoid X Receptors - Series II

edited by

Michael Schubert

and

Pierre Germain

submission deadline 30 Jun 2026 | Viewed by 485 | Submission Open

Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 30 Jun 2026 | Viewed by 365 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Cellular and Molecular Mechanisms in Reproductive Biology and Fertility

edited by

Giorgio Maria Baldini

and Antonio Malvasi

submission deadline 30 Jun 2026 | Viewed by 294 | Submission Open

Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo– maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation

(This special issue belongs to the Section Reproductive Cells and Development)

Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies

edited by Ana Rita Carlos

submission deadline 30 Jun 2026 | Viewed by 281 | Submission Open

Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies

Nuclear Pore Complex in Nanomedicine: Third Edition

edited by

Richard W. Wong

submission deadline 30 Jun 2026 | Viewed by 271 | Submission Open

Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain

The Cross-Talk Between Obesity and Metabolism

edited by

Hong Shi

submission deadline 30 Jun 2026 | Viewed by 225 | Submission Open

Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Jun 2026 | Viewed by 223 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

(This special issue belongs to the Section Cellular Neuroscience)

Hematopoietic Cell Lines as Models for Leukemia and Lymphoma

edited by Stefan Nagel

submission deadline 30 Jun 2026 | Viewed by 188 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes

Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures

edited by

Ivo Bozovic

and

Bogdan Bjelica

submission deadline 30 Jun 2026 | Viewed by 187 | Submission Open

Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures

(This special issue belongs to the Section Tissues and Organs)

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Jun 2026 | Viewed by 180 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms of Hepatobiliary Diseases

edited by

Stefan Hoehme

and

Jan G. Hengstler

submission deadline 30 Jun 2026 | Viewed by 153 | Submission Open

Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics

edited by Mangesh Dattu Hade

submission deadline 30 Jun 2026 | Viewed by 152 | Submission Open

Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine

(This special issue belongs to the Section Cellular Aging)

Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities

edited by

Vesna Ceriman Krstic

and Dragana Jovanovic

submission deadline 30 Jun 2026 | Viewed by 152 | Submission Open

Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy

(This special issue belongs to the Section Cell Microenvironment)

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 30 Jun 2026 | Viewed by 151 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

Mitochondrial Dynamics and Remodelling

edited by Edmund Carvalho

submission deadline 30 Jun 2026 | Viewed by 123 | Submission Open

Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting

Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes

edited by

Catharina Alam

submission deadline 30 Jun 2026 | Viewed by 119 | Submission Open

Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells

(This special issue belongs to the Section Cell Signaling)

Translating Extracellular Vesicle Science

edited by

Masato Mitsuhashi

and

Theresa L. Whiteside

submission deadline 30 Jun 2026 | Viewed by 115 | Submission Open

Keywords: extracellular vesicles (EVs); EV isolation; EV purification; EV characterization; EV images; EV tracking; EV-based diagnostics; EV-based monitoring; EV therapeutics; blood biomarkers; translational medicine; exosomes; cell signaling

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 30 Jun 2026 | Viewed by 111 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Nuclear Organization and Nucleocytoplasmic Transport in Neuronal Development and Disease: Mechanisms and Therapeutic Opportunities

edited by

Masood Sepehrimanesh

submission deadline 30 Jun 2026 | Viewed by 109 | Submission Open

Keywords: nuclear organization; nucleocytoplasmic transport; neuronal development; neurodegeneration; nuclear pore complex (NPC); nuclear lamina; RNA trafficking; chromatin regulation; therapeutic targeting; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Neuroscience)

Bone and Tooth Biology: Development and Regeneration

edited by Xiaofang Wang

submission deadline 30 Jun 2026 | Viewed by 109 | Submission Open

Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells

Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy

edited by Janet Van Eersel

submission deadline 30 Jun 2026 | Viewed by 90 | Submission Open

Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation

The Immunology of Allergy and Asthma

edited by

Charles Pilette

and

Valerie Hox

submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open

Keywords: type 2 immunity; rhinitis; food allergy; anaphylaxis; drug allergy; dermatitis; eczema; airway inflammation; IgE response; tissue remodelling; disease remission

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration—Second Edition

edited by