Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mechanisms Underlying Cell Growth and Development
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1102 | Submission Open
Keywords: cell growth; cell development; cell differentiation; cell cycle; mitosis; meiosis; molecular rearrangements; chromosomes; gene expression
Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 30 Apr 2026 | 1 articles | Viewed by 666 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
Role of Gamma Delta T Cells in Immunotherapy
edited by and Wenwei Tu
submission deadline 30 Apr 2026 | Viewed by 401 | Submission Open
Keywords: gamma delta T cells; adoptive cell therapy; chimeric antigen receptors; bispecific antibodies; cancer immunotherapy; tumor microenvironment; phosphoantigens; butyrophilin 2A1/3A1; virus infection; multidrug-resistant bacteria; extracellular vesicles
(This special issue belongs to the Section Cellular Immunology)
Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions
edited by Shahid Khan
submission deadline 30 Apr 2026 | Viewed by 385 | Submission Open
Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering
Synaptic Dysregulation in Nervous System Disorders
edited by Pragya Goel
submission deadline 30 Apr 2026 | Viewed by 328 | Submission Open
Keywords: synapses; synaptic transmission; synaptic plasticity; neurodegeneration; neuropsychiatric disorders; neurodevelopmental diseases
(This special issue belongs to the Section Cellular Neuroscience)
Novel Therapies and Biomarkers for Rare Diseases
edited by Reena Kartha
submission deadline 30 Apr 2026 | Viewed by 270 | Submission Open
Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine
Autophagy in Neurological Disorders submission deadline 30 Apr 2026 | Viewed by 265 | Submission Open
Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents
(This special issue belongs to the Section Cellular Neuroscience)
Interleukin-1 Signaling in Cancer: Novel Mechanisms and Therapeutic Opportunities
edited by Afshan Fathima Nawas and
submission deadline 30 Apr 2026 | Viewed by 208 | Submission Open
Keywords: interleukin-1 signaling; tumor microenvironment; inflammatory pathways; cytokine networks; cancer cell proliferation; epigenetic regulation in cancer; non-coding RNAs; immune modulation; cancer metabolism
Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer
edited by Nicola Normanno, and
submission deadline 30 Apr 2026 | Viewed by 206 | Submission Open
Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence
The Role of Integrins and Small GTPases in Health and Disease
edited by
submission deadline 30 Apr 2026 | Viewed by 184 | Submission Open
Keywords: cell signaling; integrins; cell adhesion; integrins diseases; infectious diseases
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Apr 2026 | Viewed by 169 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Kidney Development: Cellular and Molecular Insights submission deadline 30 Apr 2026 | Viewed by 117 | Submission Open
Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation
Glycosylation and Glycoproteins in Human Disease
edited by and
submission deadline 30 Apr 2026 | Viewed by 109 | Submission Open
Keywords: glycobiology; glycosylation; glycoproteins; glycolipids; glycan biomarkers; congenital disorders of glycosylation (cdg); immune modulation; glycan profiling; glycoengineering; host– pathogen interactions; therapeutic glycoproteins; bioorthogonal chemistry
Advances in Neuropathology: Cellular, Molecular and Precision Mechanisms in Neurodegenerative Diseases submission deadline 30 Apr 2026 | Viewed by 107 | Submission Open
Keywords: neurodegeneration; Alzheimer's disease; Parkinson's disease; glial cells; synaptic dysfunction; protein aggregation; lysosomal function; autophagy; precision medicine
Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open
Keywords: cancer progression; cell death; senescence; cancer therapy
Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies submission deadline 30 Apr 2026 | Viewed by 95 | Submission Open
Keywords: hematologic diseases; mechanisms; therapies
New Therapeutic Approaches to Cardiac Repair
edited by Dinakar Iyer
submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open
Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology
Noncoding RNAs: Immunity, Mechanisms, and Biomarker Potential
edited by
submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open
Keywords: noncoding RNAs (ncRNAs); MicroRNAs (miRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); immune regulation; tumor microenvironment; immune checkpoints; cancer immunotherapy; liquid biopsy biomarkers; immune evasion
Molecular Signaling and Mechanism on Vascular Remodeling
edited by Ki Ho Park and Yitao Huang
submission deadline 30 Apr 2026 | Viewed by 91 | Submission Open
Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling
Advancing Breast Cancer Research: Multi-Omics, AI, and Emerging Cellular Mechanisms
edited by Rahul Sanawar, and Satheesh Kumar Sengodan
submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open
Keywords: breast cancer; cancer stem cells; cell plasticity; immune evasion; drug resistance; tumor microenvironment; non-coding RNAs; circulating tumor cells (CTC); circulating tumor DNA (ctDNA); exosomes; signaling pathways (e.g.; PI3K/AKT; MAPK); targeted therapy; immunotherapy
Mechanisms and Therapies of Cell Death Pathways
edited by and Deniz Gulfem Ozturk
submission deadline 30 Apr 2026 | Viewed by 69 | Submission Open
Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance
(This special issue belongs to the Section Cellular Pathology)
Post-Transcriptional Control of Stem Cell Fate and Neural Development
edited by
submission deadline 30 Apr 2026 | Viewed by 46 | Submission Open
Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology
(This special issue belongs to the Section Stem Cells)
Exploiting Stem Cell Pathways for Immune Protection
edited by
submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open
Keywords: stem cell; immune tolerance; immune modulation; autoimmunity; immunosuppression; immunotherapy; immune escape; immune evasion; immune privilege; stemness
Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations
edited by
submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open
Keywords: autoimmune diseases; immune cells; lymphocytes; antigen-presenting cells; natural killer cells; innate lymphoid cells; epigenetic modifications; autoimmunity
(This special issue belongs to the Section Cellular Immunology)
Lipoprotein and Cardiovascular Diseases Therapy
edited by Verity Ramirez and Wenliang Song
submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open
Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanism of Endocrine Therapy Resistance in Breast Cancer
edited by and Clodia Osipo
submission deadline 1 May 2026 | Viewed by 50 | Submission Open
Keywords: estrogen receptor; endocrine resistance; mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings
(This special issue belongs to the Section Cellular Pathology)
Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling
edited by Joaquim Gea Guiral
submission deadline 10 May 2026 | 2 articles | Viewed by 1562 | Submission Open
Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis
LPS-Induced Inflammatory Diseases
edited by and
submission deadline 10 May 2026 | Viewed by 531 | Submission Open
Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer
edited by , Lin Yuan and Yang Yu
submission deadline 10 May 2026 | Viewed by 128 | Submission Open
Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics
Retinal Disorders: Cellular Mechanisms and Targeted Therapies
edited by
submission deadline 15 May 2026 | 5 articles | Viewed by 11205 | Submission Open
Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics
(This special issue belongs to the Section Cellular Pathology)
Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling
edited by Jianjie Ma, Long-Sheng Song, and
submission deadline 15 May 2026 | 2 articles | Viewed by 2413 | Submission Open
Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease
Placenta in Tissue Engineering and Regeneration
edited by
submission deadline 15 May 2026 | Viewed by 208 | Submission Open
Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration
Molecular and Translational Advances in Metastatic Breast Cancer Research
edited by
submission deadline 15 May 2026 | Viewed by 108 | Submission Open
Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis
The Role of Light in Ocular Health and Disease
edited by Krisztina Valter, and
submission deadline 15 May 2026 | Viewed by 99 | Submission Open
Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics
Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma
edited by , Patricia L Sullivan and Jeremy J Reynolds
submission deadline 15 May 2026 | Viewed by 47 | Submission Open
Keywords: chordoma; targeted therapy; brachyury; tumor microenvironment; epigenetics; immunotherapy; biomarkers; drug resistance; translational oncology; radiation resistance
Advances in Spermatogenesis—Second Edition
edited by and Changmin Niu
submission deadline 15 May 2026 | Viewed by 6 | Submission Open
Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception
(This special issue belongs to the Section Reproductive Cells and Development)
Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition submission deadline 20 May 2026 | 6 articles | Viewed by 8665 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
Recent Advances in the Study of Tau Protein
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3984 | Submission Open
Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions
(This special issue belongs to the Section Cellular Neuroscience)
Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
edited by Roberta Montanari and
submission deadline 20 May 2026 | 1 articles | Viewed by 2978 | Submission Open
Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms
(This special issue belongs to the Section Cellular Biophysics)
The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses submission deadline 20 May 2026 | 2 articles | Viewed by 1853 | Submission Open
Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications
(This special issue belongs to the Section Cellular Pathology)
Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease submission deadline 20 May 2026 | 1 articles | Viewed by 1654 | Submission Open
Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation
(This special issue belongs to the Section Cell Signaling)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1425 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
edited by , and Íñigo Casafont
submission deadline 20 May 2026 | Viewed by 291 | Submission Open
Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy
(This special issue belongs to the Section Cellular Metabolism)
New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets
edited by
submission deadline 20 May 2026 | Viewed by 234 | Submission Open
Keywords: cancer; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 20 May 2026 | Viewed by 159 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
(This special issue belongs to the Section Cell Microenvironment)
Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine
edited by Emanuela Mari
submission deadline 20 May 2026 | Viewed by 68 | Submission Open
Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome
(This special issue belongs to the Section Stem Cells)
Regulation of Iron Homeostasis
edited by
submission deadline 20 May 2026 | Viewed by 41 | Submission Open
Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins
Cellular and Molecular Basis of Sjögren’s Syndrome
edited by Muhammad Shahnawaz Soyfoo
submission deadline 20 May 2026 | Viewed by 38 | Submission Open
Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity
Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies
edited by Jayakumar R. Nair
submission deadline 20 May 2026 | Viewed by 36 | Submission Open
Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity                                 
(This special issue belongs to the Section Cellular Pathology)
Pathology and Therapies in Brain Tumor
edited by Bachuchu Lal
submission deadline 20 May 2026 | Viewed by 32 | Submission Open
Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models
(This special issue belongs to the Section Cellular Pathology)
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