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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)

edited by Erlinda M. Gordon,

Sant P. Chawla

and Frederick L. Hall

submission deadline 31 Dec 2025 | Viewed by 334 | Submission Open

Keywords: soft tissue sarcoma; gene therapy; natural killer cell therapy; immune and cell cycle checkpoint inhibitors; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Stereotactic Body Radiotherapy in Gynecologic Malignancies—a Practical Framework of SBRT, Chemoradiotherapy and Immunotherapy

edited by Antonio Pontoriero

submission deadline 31 Dec 2025 | Viewed by 313 | Submission Open

Keywords: SBRT; gynecologic cancer; chemoradiotherapy; immunotherapy; oligometastatic; oligoecurrent; oligopersistent; reirradiation

(This special issue belongs to the Section Cancer Therapy)

Survivorship and Life with Colorectal Cancer

edited by Daniel Steffens, Bora Kim, Rachel Campbell and Kate White

submission deadline 31 Dec 2025 | Viewed by 294 | Submission Open

Keywords: colorectal cancer; survivorship care; implementation; clinical interventions; supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Surgical Aspects of Ovarian/Tubal/Peritoneal Cancer Management

edited by

Neville F. Hacker

and

Jacobus van der Velden

submission deadline 31 Dec 2025 | Viewed by 278 | Submission Open

Keywords: primary cytoreduction; interval cytoreduction; neoadjuvant chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in the Pathogenesis of Hematopoietic Neoplasms

edited by

Raju K. Pillai

and

Steven T. Rosen

submission deadline 31 Dec 2025 | Viewed by 278 | Submission Open

Keywords: B cell lymphoma; T cell lymphoma; Hodgkin lymphoma; leukemia; myeloma; pathogenesis; genomics; microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Views and Perspectives of Robot-Assisted Liver Surgery (2nd Edition)

edited by

Roland S. Croner

, Ibrahim Dagher and

Andrew A. Gumbs

submission deadline 31 Dec 2025 | Viewed by 264 | Submission Open

Keywords: robotic; liver surgery; liver resection; hepatectomy; minimally invasive; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Research and Treatment

edited by

Huaitian Liu

submission deadline 31 Dec 2025 | Viewed by 254 | Submission Open

Keywords: breast cancer; tumor microenvironment; immune microenvironment; intratumoral heterogeneity; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Research Challenges in Adolescent and Young Adult Cancer

edited by Lorna A. Fern and Jeremy Lewin

submission deadline 31 Dec 2025 | Viewed by 241 | Submission Open

Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers

(This special issue belongs to the Section Pediatric Oncology)

Emerging Concepts in Mesothelioma

edited by Georgios T. Stathopoulos and Tonia Adamides

submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open

Keywords: mesothelioma; asbestos; pleura; tumor suppressor; cell lines; patient-derived xenograft; surgery; chemotherapy; folate antagonist; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Feature Papers in the Section “Cancer Therapy” in 2025

edited by

Abdullah Esmail

, Qiang Wang and

Hiroyuki Takei

submission deadline 31 Dec 2025 | Viewed by 211 | Submission Open

Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.

(This special issue belongs to the Section Cancer Therapy)

Oral Cancer: Prevention and Early Detection (2nd Edition)

edited by

Gianluca Tenore

and

Umberto Romeo

submission deadline 31 Dec 2025 | Viewed by 205 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Artificial Intelligence (AI), Robotics, and Cancer Surgery

edited by Zaid M. Abdelsattar

submission deadline 31 Dec 2025 | Viewed by 156 | Submission Open

Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making

(This special issue belongs to the Section Methods and Technologies Development)

Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer

edited by Tim Strate and

Jonas Herzberg

submission deadline 31 Dec 2025 | Viewed by 155 | Submission Open

Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC

(This special issue belongs to the Section Cancer Therapy)

Next-Generation Cancer Therapies

edited by

Achilleas Mitrakas

, Ioannis Lamprou and Erasmia Xanthopoulou

submission deadline 31 Dec 2025 | Viewed by 153 | Submission Open

Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines

(This special issue belongs to the Section Cancer Therapy)

Multidisciplinary Treatment with Surgery and Chemotherapy of Liver Metastases from Colorectal Cancer

edited by

Luca Viganò

and Pietro Majno

submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open

Keywords: colorectal liver metastases; liver surgery; oncology; multidisciplinary approach; prognosis; recurrence; precision medicine; genetics; tumor biology; liver transplantation; perioperative therapy and conversion therapy

(This special issue belongs to the Section Cancer Therapy)

The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes

edited by

Andrea Dell'Amore

and

Alessio Campisi

submission deadline 31 Dec 2025 | Viewed by 146 | Submission Open

Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis

edited by

Nuno Matela

and

Ana Margarida Mota

submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open

Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition

edited by

Kenta Masui

and

Linlin Guo

submission deadline 31 Dec 2025 | Viewed by 143 | Submission Open

Keywords: cancer metabolism; epigenetic reprogramming; histone modification; DNA methylation; chromatin structure; intermediary metabolites; microenvironment; mTOR complexes; glioblastoma

(This special issue belongs to the Section Cancer Pathophysiology)

Oxidative Stress-Mediated Regulation of Specific Signaling Pathways in Skin Cancers

edited by

Sanjay Premi

and

Jyoti Srivastava

submission deadline 31 Dec 2025 | Viewed by 141 | Submission Open

Keywords: reactive oxygen species; reactive nitrogen species; oxidative stress; epigenetic regulation; UV-exposure; skin pigmentation; skin cancer; melanoma

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Innovations in Microsurgical Techniques for Breast Cancer Reconstruction

edited by

Babak J. Mehrara

and Robert J. Allen

submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Innovations in Advanced Gastric Cancer

edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu

submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open

Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management

(This special issue belongs to the Section Cancer Therapy)

Cancers in Chronic HIV Infection

edited by Diego Ripamonti

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: cancer; HIV; AIDS; cancer screening; hematologic malignancy; Kaposi sarcoma; HPV; anal cancer; lymphoma

(This special issue belongs to the Section Infectious Agents and Cancer)

Head and Neck Cancer Surgery and Rehabilitation: A Bridge Between Medicine and Dentistry for Reconstruction with Regeneration

edited by

Shahram M. Ghanaati

and Samuel Ebele Udeabor

submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open

Keywords: oral squamous cell carcinoma; oral cancer; head and neck cancer; odontogenic tumors; OSCC management; tumor recurrence; tumor metastasis; adjuvant therapy; biomaterials for maxillofacial reconstruction; tissue regeneration; cancer rehabilitation

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Chemotherapy in Pancreatic Cancer

edited by

Casper H. J. Van Eijck

submission deadline 31 Dec 2025 | Viewed by 126 | Submission Open

Keywords: neoadjuvant chemotherapy; pancreatic cancer; treatment decision

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section “Methods and Technologies Development” in 2025

edited by

Damiano Caruso

and

Marta Zerunian

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into Pheochromocytoma and Paraganglioma

edited by

Wolfgang Raber

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards

(This special issue belongs to the Section Clinical Research of Cancer)

New Insights in Parotid Tumors

edited by Chiara Gaudino and Stefan Rohde

submission deadline 31 Dec 2025 | Viewed by 120 | Submission Open

Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors

(This special issue belongs to the Section Cancer Therapy)

Advanced Research in Surgical Treatment for Spinal Tumors

edited by Alessandro Gasbarrini, Stefano Bandiera and

Giuseppe Tedesco

submission deadline 31 Dec 2025 | Viewed by 115 | Submission Open

Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy

(This special issue belongs to the Section Cancer Therapy)

Clinical and Biological Studies of Pediatric Adrenocortical Tumors, Pheochromocytomas and Paragangliomas

edited by

Ronald R. de Krijger

, Verena Wiegering and

Maria Candida Barisson Villares Fragoso

submission deadline 31 Dec 2025 | Viewed by 114 | Submission Open

Keywords: adrenal gland; pheochromocytoma; paraganglioma; adrenocortical adenoma; adrenocortical carcinoma; pediatric; adrenal tumor

(This special issue belongs to the Section Pediatric Oncology)

Contemporary Trends and Advances in Minimally Invasive and Endoscopic Management of Genitourinary Malignancies

edited by

Francesco Del Giudice

submission deadline 31 Dec 2025 | Viewed by 107 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; urologic oncology; prostate cancer; urothelial cancer; kidney cancer; testicular cancer; single-port surgery; image-guided surgery; surgical outcomes; oncologic outcomes; advanced surgical techniques; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Genitourinary Cancer: Biomarkers, Immunotherapy and Novel Therapeutics

edited by Lingbin Meng

submission deadline 31 Dec 2025 | Viewed by 106 | Submission Open

Keywords: genitourinary cancer; biomarkers; immunotherapy; targeted therapy; chemotherapy; drug resistance; tumor microenvironment; liquid biopsy; ctDNA; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Hippo Signaling in Cancer (2nd Edition)

edited by

Michel Ouellette

and

Ying Yan

submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open

Keywords: Hippo signaling; Salvador– Warts– Hippo (SWH) pathway; YAP/TAZ; cancer development; progression; metastasis; therapeutic resistance

(This special issue belongs to the Section Tumor Microenvironment)

The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment

edited by

Maria Georgiadou

Eirini Velliou

and

Eugenia Roupakia

submission deadline 31 Dec 2025 | Viewed by 95 | Submission Open

Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies

(This special issue belongs to the Section Cancer Therapy)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Dec 2025 | Viewed by 89 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Faulty Ribosome Biogenesis and Cancer: Mechanisms and Therapeutic Perspectives

edited by

Paola Bellosta

and

Marianna Penzo

submission deadline 31 Dec 2025 | Viewed by 86 | Submission Open

Keywords: ribosome biogenesis; ribosomal proteins; nucleolar stress; genomic instability; oncoribosome; ribosomapathies; ribosome-targeting drugs; cancer biomarkers; animal models

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Minimally Invasive Surgery for Colorectal Cancer

edited by Jonathan S. Abelson and Christine A. Schad

submission deadline 31 Dec 2025 | Viewed by 76 | Submission Open

Keywords: colorectal cancer; minimally invasive surgery; endoscopic surgery; endoluminal surgery; laparoscopic surgery; ro-botic surgery; single incision laparoscopic surgery; postoperative outcomes; survival

(This special issue belongs to the Section Cancer Therapy)

Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma

edited by

Kalu U.E. Ogbureke

submission deadline 31 Dec 2025 | Viewed by 73 | Submission Open

Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants

(This special issue belongs to the Section Cancer Biomarkers)

Oncogenetics of Colorectal Cancer (2nd Edition)

edited by

Muhammad Kibriya

and Marc Bissonnette

submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open

Keywords: colorectal carcinoma; somatic mutation; microsatellite instability; methylation; copy number change; tumor-infiltrating leukocyte; immune checkpoint inhibitor; drug resistance; cell-free DNA

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in the Molecular Biology of Sarcoma and Drug Development

edited by Francis Hornicek and

Zhenfeng Duan

submission deadline 31 Dec 2025 | Viewed by 69 | Submission Open

Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

ALK in Cancer: Lessons from the Future (2nd Edition)

edited by

Petros Christopoulos

and

Richard Bayliss

submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open

Keywords: ALK inhibitors; ALK fusion variants; TP53 mutations; immunotherapy; liquid biopsies; disease monitoring; therapeutic sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Advanced Ovarian Cancer (2nd Edition)

edited by

Sheng-Mou Hsiao

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Pituitary Tumors: Clinical and Surgical Challenges

edited by

Michal Hlavac

and

Andrej Pala

submission deadline 31 Dec 2025 | Viewed by 54 | Submission Open

Keywords: pituitary; neuroendocrine tumors; transsphenoidal endoscopic surgery; MRI imaging; quality of life

(This special issue belongs to the Section Clinical Research of Cancer)

Leukemia Cell Signaling Pathways: Recent Advances, Future Perspectives, and Potential Clinical Applications

edited by

Bac Viet Le

and

Srinivas Chatla

submission deadline 31 Dec 2025 | Viewed by 45 | Submission Open

Keywords: leukemia; cell signaling; bone marrow microenvironment; leukemic transformation; drug resistance; therapeutic discovery; cell signaling inhibitors; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Patients’ Perspective in Gynecological Cancer

edited by

Jalid Sehouli

submission deadline 31 Dec 2025 | Viewed by 39 | Submission Open

Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Tumor Microenvironment of Gynecological Tumors

edited by

Zahid Pranjol

and

Dmitry Aleksandrovich Zinovkin

submission deadline 10 Jan 2026 | Viewed by 102 | Submission Open

Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics

(This special issue belongs to the Section Tumor Microenvironment)

The Role of Flow Cytometry in Hematologic Malignancies

edited by

Kristy Wolniak

and Lucy Fu

submission deadline 12 Jan 2026 | Viewed by 53 | Submission Open

Keywords: flow cytometry; hematology; oncology; malignancy; lymphoma; leukemia; pathology; innovation; methodology; diagnosis

(This special issue belongs to the Section Methods and Technologies Development)

Neoadjuvant Therapy of Breast Cancer

edited by

Hiroyuki Takei

and Takaaki Fujii

submission deadline 15 Jan 2026 | 8 articles | Viewed by 16870 | Submission Open

Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Cervical Cancer: Study on Molecular Landscape and Protein Biomarkers. Current Diagnostic and Therapeutic Capabilities

edited by

Christopher Kobierzycki

and

Piotr Dzięgiel

submission deadline 15 Jan 2026 | 5 articles | Viewed by 9842 | Submission Open

Keywords: cervical cancer; cervical dysplasia; human papilloma virus (HPV); tumor markers; cancerogenesis; genotyping

(This special issue belongs to the Section Molecular Cancer Biology)

Displaying special issue 601-650 on page 13 of 23.