Translational Research and Clinical Trials in Gastric Cancer: Advances and Future Directions
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research in Cancer".
Deadline for manuscript submissions: 15 November 2026 | Viewed by 720
Editor
Special Issue Information
Dear Colleagues,
Gastric cancer remains a leading cause of global cancer mortality, with substantial regional variation in stage at diagnosis, access to specialized surgery and integration of systemic therapy. While Japan and South Korea have established standardized D2 lymphadenectomy and early detection pathways, many regions continue to manage locally advanced and metastatic disease in heterogeneous care settings. Rapid advances in perioperative therapy, immunotherapy integration, surgical technology and biologic stratification underscore the need to align translational discoveries with well-designed clinical trials.
This issue will highlight cutting-edge laboratory insights and practice-changing clinical investigations across the spectrum of disease:
- Biologic rationale for treatment sequencing—neoadjuvant/perioperative therapy (e.g., FLOT ± durvalumab) versus upfront surgery
- Translational correlates of response and resistance, including tumor regression grading and biomarker-driven strategies
- Impact of modern systemic therapy on surgical complexity and outcomes, including fibrosis and operative time
- Prospective evaluation of minimally invasive and robotic gastrectomy in the post-neoadjuvant setting
- Role of staging laparoscopy and novel detection methods for occult peritoneal metastases
- Clinical trials in conversion therapy, including peritoneal-directed approaches for carcinomatosis and liver-directed therapy or hepatectomy for oligometastatic disease
- Molecular profiling and immunotherapy integration in localized and metastatic disease
- Centralization, surgical quality metrics and global trial harmonization
Together, these topics emphasize the bidirectional integration of translational science and clinical trial innovation to advance precision, multidisciplinary gastric cancer care.
Dr. Yanghee Woo
Guest Editor
Manuscript Submission Information
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Keywords
- gastric cancer
- multidisciplinary management
- conversion gastrectomy
- molecular biomarker testing
- diagnostic laparoscopy
- neoadjuvant therapy
- upfront surgery
- intraperitoneal treatment
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