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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Liquid Biopsy Technology Development and Clinical Applications in Cancer Research and Treatment

edited by

Yong-Jie Lu

and Xia Yu

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2997 | Submission Open

Keywords: liquid biopsy; biomarkers; circulating tumor cells; circulating nucleic acids; extracellular vesicles; proteins; cancer early detection; prognosis; personalized treatment; real-time monitoring

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers

edited by

Andrea Belli

, Matteo Serenari and

Benedetto Ielpo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2962 | Submission Open

Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy

(This special issue belongs to the Section Cancer Therapy)

Biologic Advancements in Childhood and Adolescent Cancers: From Disease Mechanisms to Precision Therapies

edited by

Emmanouel Hatzipantelis

and Eleni Tsotridou

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2902 | Submission Open

Keywords: pediatric oncology; precision therapies; molecular vulnerabilities; biomarker-driven trials; disease mechanisms

(This special issue belongs to the Section Pediatric Oncology)

Surgical and Non-Surgical Convergence in Hepatocellular Carcinoma

edited by

Alessandro Vitale

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2865 | Submission Open

Keywords: hepatocellular carcinoma; conversion therapy; HCC treatment boundaries; surgical–non-surgical convergence; multidisciplinary HCC management

(This special issue belongs to the Section Cancer Therapy)

Thyroid Cancer: Diagnosis, Prognosis and Treatment—3rd Edition

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2833 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

Precision Medicine in Acute Myeloid Leukemia

edited by

Ugo Testa

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2458 | Submission Open

Keywords: acute myeloid leukemia; precision medicine; molecular targeting; DNA sequencing

Novel Genomic Strategies for Personalized Cancer Treatment

edited by Honey Reddi and

Guo-Min Li

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2206 | Submission Open

Keywords: precision medicine; assay validation; solid tumors; molecular methodologies; liquid biopsy

(This special issue belongs to the Section Molecular Cancer Biology)

Tumorigenesis and Tumor Microenvironment—Insights and Interventions (TTMII)

edited by

Renu Wadhwa

Sunil C. Kaul

and

Ajaikumar B. Kunnumakkara

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2111 | Submission Open

Keywords: tumorigenesis; tumor microenvironment; intervention; stress biology; aging; mortalin; CARF; ashwagandha; propolis; curcumin; natural compounds

(This special issue belongs to the Section Tumor Microenvironment)

Mechanisms of Therapy Resistance in Cancers—2nd Edition

edited by

Birandra K. Sinha

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1984 | Submission Open

Keywords: ATP-binding cassette transporters; cancer stem cells; extracellular ATP; repair of DNA damage; immunotherapy resistance

(This special issue belongs to the Section Cancer Drug Development)

Advances in Electroporation-Based Technologies for Cancer Treatment

edited by

Bostjan Markelc

and

Gregor Sersa

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1959 | Submission Open

Keywords: electroporation; electrochemotherapy; gene electrotransfer; interleukin-12; DNA vaccination; irreversible electroporation; cancer immunotherapy; tumor ablation

(This special issue belongs to the Section Methods and Technologies Development)

New Perspectives in Skin Cancer: From Biology to Therapy

edited by Marija Buljan

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1933 | Submission Open

Keywords: skin cancer; melanoma and non-melanoma skin cancer; tumor biology; early diagnosis; targeted therapy; immunotherapy; epidemiology

Means of Improving Gastric Cancer Response to Chemotherapy and Immunotherapy

edited by

Beate Rau

and

Kazuo Kobayashi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1823 | Submission Open

Keywords: gastric cancer; chemotherapy response; immunotherapy; treatment adherence; adverse event management; oncology pharmacy; pharmacist intervention; oral anticancer agents; medication safety

Circulating Tumor DNA and Liquid Biopsy

edited by Atocha Romero

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1689 | Submission Open

Keywords: ctDNA; MRD; fragmentomics; extracellular vesicles (EVs); cell-free RNA (cfRNA); cell-free DNA (cfDNA); and microRNA (miRNA)

(This special issue belongs to the Section Tumor Microenvironment)

ALK in Cancer: Lessons From the Future (2nd Edition)

edited by

Petros Christopoulos

and

Richard Bayliss

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1648 | Submission Open

Keywords: ALK inhibitors; ALK fusion variants; TP53 mutations; immunotherapy; liquid biopsies; disease monitoring; therapeutic sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Radiologic Imaging of Hepatocellular Carcinomas

edited by

Masakatsu Tsurusaki

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1330 | Submission Open

Keywords: machine learning/deep learning; radiomics; imaging biomarkers; hepatocellular carcinoma; CT; MRI; PET/CT; Gd-EOB-DTPA; LI-RADS; therapeutic response assessment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Peripheral Nerve Tumors

edited by

Cordula Matthies

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1308 | Submission Open

Keywords: electrophysiology; malignant peripheral nerve sheath tumors; nerve sheath collision tumors; neurofibromas; neurofibromatosis type 1; NF2-associated schwannomatosis; non-NF2-associated schwannomatosis; schwannomas; untypical neurofibromas of uncertain biological potential

Advances in Acute Lymphoblastic Leukemia Treatment

edited by

Roberta Buono

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1306 | Submission Open

Keywords: acute lymphoblastic leukemia; biology; clinical trial; treatment; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Metals in Cancer: From Molecular Mechanisms to Innovative Therapeutics

edited by

Katarina Zivancevic

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1126 | Submission Open

Keywords: essential and toxic metals; metal-induced carcinogenesis; metal homeostasis; metallotherapeutics; oxidative stress; tumor microenvironment; immune modulation; metabolic reprogramming; therapy resistance; drug delivery systems

(This special issue belongs to the Section Molecular Cancer Biology)

Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications

edited by Francesco Mattioli,

Alfredo Lo Manto

and Edoardo Serafini

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1013 | Submission Open

Keywords: laryngeal cancers; diagnosis; laryngeal surgery; transoral laser microsurgery; transoral robotic surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Machine Learning and Artificial Intelligence in Leukemia

edited by Garrett M. Dancik and

Spiros Vlahopoulos

submission deadline 31 Jan 2027 | 1 articles | Viewed by 930 | Submission Open

Keywords: cancer genomics; genomic sequencing; biomarkers; predictive modeling; machine learning; artificial intelligence; leukemia; computer vision; natural language processing

(This special issue belongs to the Section Methods and Technologies Development)

Resection and Reconstruction for Breast Cancer

edited by Radoslaw Tarkowski and

Gilles Houvenaeghel

submission deadline 31 Jan 2027 | 1 articles | Viewed by 866 | Submission Open

Keywords: oncoplastic breast surgery; breast reconstruction; breast cancer

(This special issue belongs to the Section Clinical Research in Cancer)

Implementation of Physical Activity Promotion in Cancer Care (2nd Edition)

edited by Sarah Hardcastle

submission deadline 31 Jan 2027 | 1 articles | Viewed by 780 | Submission Open

Keywords: physical activity; cancer survivors; behavior change; interventions; cancer care; implementation; health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Prognostic Biomarkers and Systemic Inflammation in Gastric Cancer: From Translational Research to Clinical Application

edited by

Konrad Matysiak

and Steve Kwon

submission deadline 31 Jan 2027 | 1 articles | Viewed by 767 | Submission Open

Keywords: gastric cancer; prognostic biomarkers; systemic inflammation; nutritional status; immune-inflammatory indices; survival prediction; clinical outcomes

Environmental Toxicology and Cancer: Mechanisms, Risk Assessment and Therapeutic Implications

edited by

Inamul Haque

submission deadline 31 Jan 2027 | 1 articles | Viewed by 733 | Submission Open

Keywords: environmental carcinogenesis; toxicogenomics; particulate matter (PM2.5); aryl hydrocarbon receptor signaling; oxidative stress and DNA damage; clonal hematopoiesis of indeterminate potential; epigenetic reprogramming; endocrine disruptors; air pollution; lung cancer; hematological malignancies

Advances in First-Line and Second-Line Treatment Research for Renal Cell Carcinoma

edited by

Francesco Ditonno

Celeste Manfredi

and Antonio Franco

submission deadline 31 Jan 2027 | 1 articles | Viewed by 718 | Submission Open

Keywords: renal cell carcinoma; immune checkpoint inhibitors; patient selection; precision medicine; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Updates in Cancer Imaging: PET/CT, MRI and Beyond

edited by

Francesco Dondi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 664 | Submission Open

Keywords: positron emission tomography/computed tomography; computed tomography; MR; conventional imaging; positron emission tomography; neoplasm; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Driving Progress in Urological Cancer Outcomes: Predictive Factors and Treatment Innovations

edited by Juan Gómez Rivas

submission deadline 31 Jan 2027 | 1 articles | Viewed by 653 | Submission Open

Keywords: urological cancers; prostate cancer; bladder cancer; kidney cancer; prognostic factors; treatment outcomes

Blood Stem Cell and Hematological Malignancies (Second Edition)

edited by Dirk Loeffler

submission deadline 31 Jan 2027 | 1 articles | Viewed by 604 | Submission Open

Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation

(This special issue belongs to the Section Molecular Cancer Biology)

Redefining Cancer Through Its Microenvironment: Mechanisms, Modeling, and Targeting Strategies

edited by Leandro Marcelo Martinez

submission deadline 31 Jan 2027 | 2 articles | Viewed by 595 | Submission Open

Keywords: tumor microenvironment; solid cancer; hematologic malignancies; tumor initiation; tumor progression; therapeutic resistance; in-vitro models; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications

edited by

Hong Chang

and

Shamila D. Alipoor

submission deadline 31 Jan 2027 | Viewed by 534 | Submission Open

Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes

(This special issue belongs to the Section Cancer Therapy)

Multimodal Management of Bone Metastases: From Microenvironment Crosstalk to Precision Interventional Therapy

edited by

Zhengxue Quan

and Zhiyu Chen

submission deadline 31 Jan 2027 | 1 articles | Viewed by 482 | Submission Open

Keywords: bone metastases; tumor microenvironment; precision therapy; molecular mechanisms; multimodal treatment; therapeutic targets

(This special issue belongs to the Section Cancer Metastasis)

Artificial Intelligence in Radiation Therapy for Head and Neck Cancers: Prediction, Personalization, and Precision

edited by Meysam Tavakoli

submission deadline 31 Jan 2027 | Viewed by 461 | Submission Open

Keywords: head and neck cancer; radiation therapy; artificial intelligence ; machine learning ; deep learning ; toxicity prediction ; radiomics ; dosiomics ; outcome modeling ; personalized radiotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Trials for Hepatobiliary and Pancreatic Cancer Diagnosis and Treatment (2nd Edition)

edited by

Takuji Okusaka

submission deadline 31 Jan 2027 | Viewed by 417 | Submission Open

Keywords: biliary cancer; liver cancer; pancreatic cancer; clinical trial; diagnosis; surgery; neoadjuvant therapy; adjuvant therapy; radiotherapy; chemotherapy; targeted therapy; precision medicine; immunotherapy; biliary and duodenal stent; psycho-oncology; palliative and supportive care

(This special issue belongs to the Section Clinical Research in Cancer)

Digital Health and Patient-Reported Outcomes in Cancer Care

edited by Joanne Droney

submission deadline 31 Jan 2027 | Viewed by 390 | Submission Open

Keywords: patient-reported outcome measures; digital health; remote symptom monitoring; outcome-based healthcare; health-related quality of life (HRQoL); shared decision-making; real-world data collection; data standardization; health equity in digital health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Microsatellite Instability in Colorectal Cancer

edited by

Joan Maurel

and Vicente Alonso-Orduña

submission deadline 31 Jan 2027 | Viewed by 386 | Submission Open

Keywords: microsatellite instability; colorectal cancer; immune checkpoint inhibitors; immune signatures

(This special issue belongs to the Section Tumor Microenvironment)

Nanomedicine for Cancer Treatment

edited by Youssef Wahib Naguib

submission deadline 31 Jan 2027 | Viewed by 337 | Submission Open

Keywords: cancer nanomedicine; CRISPR/CAS9 nanomedicine; immune checkpoint inhibitors; cancer immunotherapy; targeted therapeutics; targeted nanoparticles; cell-penetrating peptides

(This special issue belongs to the Section Cancer Drug Development)

Advances in Exosomes and Cancer Therapy

edited by

Nadir Arber

and

Shiran Shapira

submission deadline 31 Jan 2027 | Viewed by 300 | Submission Open

Keywords: exosomes; extracellular vesicles; isolation of exosomes; cancer therapy; tumor microenvironment; exosome engineering; drug delivery systems; cancer biomarkers; immunomodulation; precision oncology

(This special issue belongs to the Section Cancer Therapy)

The TGF-β Pathway in Hepatocellular Carcinoma

edited by Dan Feng

submission deadline 31 Jan 2027 | Viewed by 299 | Submission Open

Keywords: hepatocellular carcinoma; HCC; TGF-β

(This special issue belongs to the Section Cancer Pathophysiology)

Thoracic Surgical Oncology—Current Landscape and Future Directions

edited by Piergiorgio Solli and Alessia Stanzi

submission deadline 31 Jan 2027 | Viewed by 273 | Submission Open

Keywords: minimally invasive thoracic surgery; immunotherapy; liquid biopsy; lung cancer; mesothelioma; esophageal cancer; precision oncology

(This special issue belongs to the Section Clinical Research in Cancer)

Advances and Challenges in Charged Particle Therapy: Protons and Beyond

edited by Annie W. Chan

submission deadline 31 Jan 2027 | Viewed by 242 | Submission Open

Keywords: proton therapy; carbon ion therapy; helium ion therapy; charged particle therapy; relative biological effectiveness

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Molecular Biology and Genetics of Prostate Cancer

edited by

Grinu Mathew

and

Maher Y. Abdalla

submission deadline 31 Jan 2027 | Viewed by 239 | Submission Open

Keywords: prostate cancer; treatment resistance; tumor microenvironment; genomic alterations; therapy progression mechanisms

(This special issue belongs to the Section Molecular Cancer Biology)

Paradigm Shifts and Patient-Centered Outcomes of Breast Cancer Surgery

edited by Rakhshanda Layeequr Rahman, Cathy Graham and Jaime Alberty

submission deadline 31 Jan 2027 | Viewed by 232 | Submission Open

Keywords: shared decision-making; precision medicine; surgical de-escalation; minimally invasive surgery; clinical approaches with modern technologies; quality of life after breast surgery; economic impact of breast cancer surgery; financial toxicity

(This special issue belongs to the Section Methods and Technologies Development)

Molecular and Genetic Drivers of Cancer: Organelle Dysfunction, Cancer Stem Cells, and Tumor Progression

edited by

Babak Behnam

and Maziar Ashrafian-Bonab

submission deadline 31 Jan 2027 | Viewed by 182 | Submission Open

Keywords: cancer progression; organelle dysfunction; cancer stem cells; mitochondria; microtubules; organelle crosstalk; tumor metabolism; therapeutic resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Anticancer Drugs and Pharmacotherapy of Cancer

edited by

Yong Weon Yi

submission deadline 31 Jan 2027 | Viewed by 149 | Submission Open

Keywords: anticancer; therapeutics; target therapy; immune-oncology; mode of action; molecular mechanisms; targeted protein degradation; antibody-drug conjugates; cell therapy; cancer parmacology

(This special issue belongs to the Section Cancer Drug Development)

Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers: 2nd Edition

edited by

Ali Zaidi

and Neda Dadgar

submission deadline 31 Jan 2027 | Viewed by 132 | Submission Open

Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry

(This special issue belongs to the Section Cancer Biomarkers)

Precision Oncology and Immunotherapy in Bone and Soft Tissue Sarcomas

edited by

Dana Borcherding

and

Ariana Mooradian

submission deadline 31 Jan 2027 | Viewed by 116 | Submission Open

Keywords: soft tissue sarcoma (STS); immunotherapy; precision medicine; cellular signaling; biomarkers; translational research; molecular profiling; survivorship; supportive care

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Endoscopic and Minimally Invasive Approaches in Neuro-Oncology

edited by Michael Karsy and

Nasser K. Yaghi

submission deadline 31 Jan 2027 | Viewed by 110 | Submission Open

Keywords: endoscopic neurosurgery; minimally invasive neuro-oncology; skull base tumors; surgical robotics and navigation; translational neuro-oncology

The Future Is Now: Novel Technologies in Use in Head and Neck Cancer Surgery

edited by Peter T. Dziegielewski, Daniel A. Benito, Austin S. Lam and Dustin Conrad

submission deadline 31 Jan 2027 | Viewed by 105 | Submission Open

Keywords: head and neck cancer; surgery; reconstruction

(This special issue belongs to the Section Cancer Therapy)

Focal Adhesion Kinase Signaling in Cancers

edited by

Dwayne Stupack

submission deadline 31 Jan 2027 | Viewed by 103 | Submission Open

Keywords: focal adhesion kinase (FAK); tumor microenvironment (TME); fibrosis; chemoresistance; immunotherapy; KRAS; BRAF; epithelial–mesenchymal transition (EMT) homologous repair deficiency; FAK inhibitor; ifebemtinib; defactinib; narmafotinib; integrin; metastasis; mechanotransduction

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in PET/CT-Guided Diagnosis and Treatment of Hematologic Malignancies

edited by

Domenico Albano

submission deadline 31 Jan 2027 | Viewed by 101 | Submission Open

Keywords: PET/CT; nuclear medicine; lymphoma; multiple myeloma; leukemia; hybrid imaging

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