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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)
edited by Shi-Ming Tu, Louis L. Pisters and
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2273 | Submission Open
Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness
(This special issue belongs to the Section Cancer Pathophysiology)
Chemo-Radio-Immunotherapy for Colorectal Cancer
edited by Shoichi Hazama
submission deadline 30 Apr 2026 | 3 articles | Viewed by 2217 | Submission Open
Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery
(This special issue belongs to the Section Cancer Therapy)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2022 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
From Molecular Insights to Cancer Treatments: Progress in Translational Science
edited by , Dhanir Tailor and
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1915 | Submission Open
Keywords: cancer biology; therapeutics; molecular targets; translational research
(This special issue belongs to the Section Cancer Therapy)
Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next
edited by and
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1867 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1836 | Submission Open
Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
(This special issue belongs to the Section Cancer Therapy)
Exosomes in Cancer Metastasis (2nd Edition) submission deadline 30 Apr 2026 | 1 articles | Viewed by 1781 | Submission Open
Keywords: exosomes; biomarkers; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
The Latest Advancements in Cutaneous Melanoma
edited by Zhenyu Ji
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1774 | Submission Open
Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers
(This special issue belongs to the Section Cancer Therapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1638 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes
edited by and Vittoria Disciglio
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1616 | Submission Open
Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant
(This special issue belongs to the Section Cancer Pathophysiology)
Prostate Cancer: Contemporary Standards and Challenges submission deadline 30 Apr 2026 | 1 articles | Viewed by 1552 | Submission Open
Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation
(This special issue belongs to the Section Cancer Therapy)
Glioma: From Intracellular Oncogenic Pathways to Targeting Therapeutic Strategies
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1346 | Submission Open
Keywords: glioma; targeted therapies; resistance mechanisms; oncogenic pathways; therapeutic resistance; combination therapies; tumor heterogeneity
(This special issue belongs to the Section Cancer Therapy)
Immune Biomarkers and Checkpoint Inhibitors: Advancing Immunotherapy in Gynecologic Cancers
edited by Ting-Tai Yen and Eugene Patrick Toy
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1333 | Submission Open
Keywords: immune checkpoints; checkpoint inhibitors; PD-1/PD-L1 pathway; immune biomarkers; tumor microenvironment; immunosuppressive pathways; T-cell activation in solid tumors; gynecologic tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Innovations in Endocrine Cancer—Technology, Techniques and Therapy (Second Edition)
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1300 | Submission Open
Keywords: endocrine cancer; thyroid cancer; parathyroid; adrenals; melanoma; pancreas; neoplasms; minimally invasive surgeries
(This special issue belongs to the Section Methods and Technologies Development)
Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1159 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
Image-Guided Treatment of Liver Tumors
edited by and Niek Wijnen
submission deadline 30 Apr 2026 | 2 articles | Viewed by 822 | Submission Open
Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology
(This special issue belongs to the Section Cancer Therapy)
Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology
edited by Evrim Erdemogľu
submission deadline 30 Apr 2026 | 1 articles | Viewed by 745 | Submission Open
Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery
(This special issue belongs to the Section Clinical Research of Cancer)
The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods
edited by Peter C. Angeletti
submission deadline 30 Apr 2026 | 1 articles | Viewed by 650 | Submission Open
Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Molecular Pathogenesis of T-Cell Lymphoma
edited by
submission deadline 30 Apr 2026 | Viewed by 452 | Submission Open
Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers
(This special issue belongs to the Section Cancer Pathophysiology)
Medical Treatment for Urological Cancers submission deadline 30 Apr 2026 | Viewed by 440 | Submission Open
Keywords: prostate cancer; urothelial cancer; renal cancer; antibody– drug conjugates; cytotoxic chemotherapy; immune checkpoint inhibitors
(This special issue belongs to the Section Cancer Therapy)
The Biomarkers of Oral Cancer
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 422 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 404 | Submission Open
Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP  models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost 
(This special issue belongs to the Section Cancer Therapy)
The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications
edited by
submission deadline 30 Apr 2026 | Viewed by 361 | Submission Open
Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application
(This special issue belongs to the Section Tumor Microenvironment)
Current Concept and Management of Pediatric ATRTs—2nd Edition
edited by and Alicia C. Lenzen
submission deadline 30 Apr 2026 | 1 articles | Viewed by 359 | Submission Open
Keywords: atypical teratoid rhabdoid tumors (ATRTs); CNS tumor; embryonal tumors
(This special issue belongs to the Section Pediatric Oncology)
Cancer Inhibitory Receptors and Related Cancer Immunotherapy
edited by Keqiang Chen, Feng Zhu and Xin Li
submission deadline 30 Apr 2026 | Viewed by 348 | Submission Open
Keywords: cancer inhibitory receptors; ligands for inhibitor receptors; immune checkpoint inhibitors; cancer cells; immune cells; non-immune cells; inhibitor receptor pathways; immune checkpoint blockade therapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeted Therapies for Pediatric Nervous System Tumors
edited by and Nicole Brossier
submission deadline 30 Apr 2026 | Viewed by 342 | Submission Open
Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma
(This special issue belongs to the Section Pediatric Oncology)
Precision Medicine in Hematological Malignancies: Current Insights and Future Directions
edited by Giuseppe Saglio and Mohamed Yassin
submission deadline 30 Apr 2026 | Viewed by 263 | Submission Open
Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling
(This special issue belongs to the Section Cancer Therapy)
Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy
edited by Heena Kumra and Makoto Noda
submission deadline 30 Apr 2026 | Viewed by 260 | Submission Open
Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment
edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna
submission deadline 30 Apr 2026 | Viewed by 233 | Submission Open
Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Artificial Intelligence in Thyroid, Thoracic and Gastrointestinal Tumors: Transforming the Landscape of Diagnosis and Treatment submission deadline 30 Apr 2026 | Viewed by 232 | Submission Open
Keywords: artificial intelligence; thyroid cancer; thoracic cancer; gastrointestinal cancer; diagnosis; medical imaging; treatment; surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers
edited by Patriciu Achimas-Cadariu and
submission deadline 30 Apr 2026 | Viewed by 223 | Submission Open
Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers
Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications submission deadline 30 Apr 2026 | Viewed by 176 | Submission Open
Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes
(This special issue belongs to the Section Cancer Therapy)
Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer submission deadline 30 Apr 2026 | Viewed by 175 | Submission Open
Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
The Changing Paradigms in the Management of Thyroid Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 171 | Submission Open
Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Apr 2026 | Viewed by 161 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 154 | Submission Open
Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy
(This special issue belongs to the Section Cancer Metastasis)
Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes
edited by
submission deadline 30 Apr 2026 | Viewed by 143 | Submission Open
Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy submission deadline 30 Apr 2026 | Viewed by 127 | Submission Open
Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft
(This special issue belongs to the Section Cancer Therapy)
Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life
edited by , and Juan Carlos Hernández-Rodríguez
submission deadline 30 Apr 2026 | Viewed by 126 | Submission Open
Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers submission deadline 30 Apr 2026 | Viewed by 125 | Submission Open
Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up
(This special issue belongs to the Section Cancer Therapy)
PARP Inhibitors in Cancers: 2nd Edition submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open
Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
Management of Orbital Tumors
edited by
submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open
Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques
(This special issue belongs to the Section Clinical Research of Cancer)
Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours
edited by Crispin T. Hiley and Iain Phillips
submission deadline 30 Apr 2026 | Viewed by 119 | Submission Open
Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR
(This special issue belongs to the Section Cancer Therapy)
EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open
Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer
(This special issue belongs to the Section Cancer Therapy)
Non-Melanoma Skin Cancer: Promises and Challenges submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open
Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique
(This special issue belongs to the Section Cancer Therapy)
Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies
edited by Giuseppe Marulli
submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery
(This special issue belongs to the Section Cancer Therapy)
Liquid Biopsies in Gynecologic Cancer
edited by , and Ludovica Pepe
submission deadline 30 Apr 2026 | Viewed by 98 | Submission Open
Keywords: liquid biopsy; gynecologic cancer; circulating tumor DNA (ctDNA); ovarian cancer; endometrial cancer; cervical cancer; early detection; personalized medicine; cancer monitoring; non-invasive diagnostics
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Research and Clinical Applications of Gynecologic Cancer Detection Technologies
edited by Porfyrios Korompelis
submission deadline 30 Apr 2026 | Viewed by 95 | Submission Open
Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Research on the Relationship Between Diet and Cancer Development (2nd Edition)
edited by
submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open
Keywords: diet; nutrition; complementary therapy; vitamins; minerals; micro-nutrients; survival; cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research
edited by and Tamer Saad Kaoud
submission deadline 30 Apr 2026 | Viewed by 93 | Submission Open
Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research
(This special issue belongs to the Section Clinical Research of Cancer)
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