New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 653

Special Issue Editor


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Guest Editor
Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 81100 Caserta, CE, Italy
Interests: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
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Special Issue Information

Dear Colleagues,

This Special Issue of Cancer aims to explore diagnostic and therapeutic innovations in gynecologic carcinomas. Despite advances in understanding their molecular basis, the treatment and management of these malignancies remain a significant challenge. The ultimate goal is to explore new strategies to improve early diagnosis, identify predictive biomarkers, and develop personalized approaches, focusing on immunotherapy, targeted therapies, and precision medicine.

In addition, innovative aspects in surgery, radiation therapy, and integrative therapies will be addressed. We welcome original contributions and reviews highlighting the latest findings, with the intension of providing a comprehensive overview of future opportunities to improve patients’ survival and quality of life.

Researchers are invited to contribute to this Special Issue with novel original trials, reviews, and meta-analyses to raise awareness of gynecological cancer. We invite oncologists, gynecologists, biologists, nurses, psychologists, and researchers in related fields to contribute their robust scientific manuscripts. 

I look forward to receiving your contributions.

Dr. Carlo Ronsini
Guest Editor

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Keywords

  • gynecologic oncology
  • surgical gynecology
  • biomarkers
  • endometrial carcinoma
  • ovarian carcinoma
  • cervical carcinoma

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Published Papers (1 paper)

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14 pages, 1482 KiB  
Systematic Review
Safety and Efficacy Outcomes of Robotic, Laparoscopic, and Laparotomic Surgery in Severe Obese Endometrial Cancer Patients: A Network Meta-Analysis
by Carlo Ronsini, Mario Fordellone, Eleonora Braca, Mariano Catello Di Donna, Maria Cristina Solazzo, Giuseppe Cucinella, Cono Scaffa, Pasquale De Franciscis and Vito Chiantera
Cancers 2025, 17(12), 2018; https://doi.org/10.3390/cancers17122018 - 17 Jun 2025
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Abstract
Background: The surgical management of endometrial cancer in severely obese patients (BMI ≥ 40) presents unique challenges. This study evaluates the outcomes of various surgical approaches in terms of safety and efficacy in lymph node retrieval. Methods: A systematic review and network meta-analysis [...] Read more.
Background: The surgical management of endometrial cancer in severely obese patients (BMI ≥ 40) presents unique challenges. This study evaluates the outcomes of various surgical approaches in terms of safety and efficacy in lymph node retrieval. Methods: A systematic review and network meta-analysis focused on intra-operative complications, post-operative complications, severe complications, and complete surgical staging rates. The analysis included 1163 patients, following a pre-specified methodology based on the PRISMA-NMA guidelines. The study was registered on PROSPERO with protocol number CRD 395959. Results: Intra-operative complications: No significant difference was found between minimally invasive surgery (MIS, 233 patients) and laparotomy (LPT) (OR 0.68 [95% CI 0.21–2.26], p = 0.18). However, robotic surgery showed a significantly lower risk (OR 0.28 [0.10–0.74]). Post-operative complications: The MIS group (457 patients) had a lower risk compared to LPT (OR 0.41 [0.26–0.64]). Network analysis: Robotic surgery had a 70.7% probability of reducing intra-operative complications compared to laparoscopy (LPS) and a 99.2% probability compared to LPT. Laparoscopy was the safest option for post-operative complications, with a 74.3% probability. Robotic surgery had an 82.4% probability of achieving complete surgical staging compared to LPT. Conclusions: Robotic surgery shows superior outcomes for complete lymph nodal staging in obese endometrial cancer patients, while LPS is favorable for post-operative complications. Further studies are needed to optimize strategies. Full article
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