Targeted Therapies for Pediatric Nervous System Tumors
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Pediatric Oncology".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 1792
Special Issue Editors
Interests: pediatric low-grade gliomas; cell therapy for brain tumors; CNS germ cell tumors
Special Issue Information
Dear Colleagues,
Brain tumors have surpassed leukemia to become the most common neoplasm in the pediatric population, representing a major source of morbidity and mortality. Peripheral nervous system tumors, while less common than brain tumors in the pediatric population, have also been noted as clinically challenging. While traditional therapeutic interventions, including surgical resection followed by chemotherapy and/or radiation therapy, have improved survival rates for many pediatric nervous system tumors, they have been associated with significant long-term side effects. Furthermore, patients with certain tumor types still face dismal outcomes. Consequently, targeted therapeutic agents have been investigated across almost all pediatric nervous system tumors, which has led to impressive responses in some tumors and disappointing results in others. This Special Issue will focus on the current role of targeted therapies in managing pediatric nervous system tumors, as well as alternative approaches that are still under investigation.
Dr. Mohamed S. Abdelbaki
Dr. Nicole Brossier
Guest Editors
Manuscript Submission Information
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Keywords
- glioma
- ependymoma
- medulloblastoma
- pediatric brain tumors
- targeted therapy
- MEK inhibitors
- NTRK inhibitors
- glioma neuroscience
- diffuse intrinsic pontine glioma
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