Prostate Cancer: Contemporary Standards and Challenges
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 23 October 2025 | Viewed by 269
Special Issue Editors
Interests: risk-adapted therapy in prostate cancer; management of oligometastatic cancer; treatment de-escalation in prostate cancer; precision medicine; chemotherapy; hormonal therapy
Interests: prostate cancer; overcoming therapeutic resistance using evolutionary biology and game theoretical concepts; risk-adapted therapy in prostate cancer; treatment de-escalation in prostate cancer; precision medicine; chemotherapy; hormonal therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As the second most common cancer among men worldwide, prostate cancer is a major public health concern, and its incidence is rising. In recent decades, researchers have made substantial progress in the molecular characterization, diagnosis, and treatment of this disease, which have greatly improved the outcomes of men with prostate cancer. Breakthroughs in theranostics leveraging the highly prevalent expression of the prostate-specific membrane antigen and improved genetic understanding of the role defects in the homologous recombination pathway play in carcinogenesis have paved the way for truly personalized management.
Recent attempts at intensifying treatment using multiagent combinations have significantly prolonged survival for many patients. However, recognizing the wide variability in clinical behavior of prostate cancer, concerns remain about overtreating some with more indolent, hormone-responsive disease.
Ongoing trials tackle questions surrounding adequate risk stratification, and many have built-in escalation or de-escalation strategies to balance the efficacy and toxicity burden of novel treatments. In this Special Issue, we aim to provide a comprehensive, multidisciplinary, and contemporary perspective on current standards and challenges in the management of prostate cancer.
To this end, we welcome original research, as well as comprehensive reviews and opinion pieces from experts and researchers in the field.
Dr. Filip Ionescu
Dr. Jingsong Zhang
Guest Editors
Manuscript Submission Information
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Keywords
- prostate cancer
- molecular pathogenesis
- precision oncology
- biomarkers
- treatment de-escalation
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