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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Survivorship and Quality of Life in Endometrial Cancer
edited by George Koukourakis, , Georgios Angelopoulos and Anthi Miliadou
submission deadline 31 May 2026 | 1 articles | Viewed by 1213 | Submission Open
Keywords: endometrial cancer; quality of life; survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Neoadjuvant Chemotherapy and Radiotherapy for Breast Cancer: Surgical Impact and Clinical Outcomes
edited by Amparo García-Tejedor
submission deadline 31 May 2026 | 1 articles | Viewed by 1187 | Submission Open
Keywords: neoadjuvant chemotherapy; radiotherapy; breast cancer; surgical outcomes; tumor downstaging; personalized therapy; breast-conserving surgery; mastectomy; clinical outcomes
(This special issue belongs to the Section Cancer Therapy)
Current Status and Prospects of Multimodal Treatment for Upper Gastrointestinal Cancer
edited by Koichi Okamoto
submission deadline 31 May 2026 | 1 articles | Viewed by 1058 | Submission Open
Keywords: upper gastrointestinal cancer; esophageal cancer; gastric cancer; esophagogastric junction cancer; chemotherapy; oncology; endoscopic resection; minimally invasive surgery; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
Nano-Targeting of Cancer
edited by Thomas Ming Swi Chang OC MD CM PhD DSc FRCPC FRSC FCAHS
submission deadline 31 May 2026 | 1 articles | Viewed by 902 | Submission Open
Keywords: drug delivery; artificial intelligence; targeted delivery; nanorobotics; prodrug activation; intracellular action; liposome; PEGylation; nanoparticles; nanocapsules; nanoartificial cells
(This special issue belongs to the Section Cancer Therapy)
Decoding the Dynamic Matrix Complexity in Cancer submission deadline 31 May 2026 | Viewed by 445 | Submission Open
Keywords: extracellular matrix; cancer pathobiology; 3D spheroids/organoids; modeling tumor microenvironment complexity; matrix-based bioscaffolds; matrix remodeling; cell surface matrix mediators and effectors; matrix degrading enzymes; proteoglycans/glycosaminoglycans; collagen; matrix (glyco)proteins; molecular targeting
(This special issue belongs to the Section Tumor Microenvironment)
Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment
edited by Ewa Robak and
submission deadline 31 May 2026 | Viewed by 417 | Submission Open
Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia
(This special issue belongs to the Section Molecular Cancer Biology)
Emerging Nanotechnology and Advanced Materials for Cancer Therapy
edited by
submission deadline 31 May 2026 | Viewed by 256 | Submission Open
Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology
(This special issue belongs to the Section Methods and Technologies Development)
PET/CT in Radiation Oncology
edited by Gurdip Azad and
submission deadline 31 May 2026 | Viewed by 224 | Submission Open
Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Multimodality Management of Sarcomas (2nd Edition)
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 199 | Submission Open
Keywords: sarcomas; multimodal; pathology; radiology; surgery; chemotherapy; radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers
edited by , Matteo Serenari and
submission deadline 31 May 2026 | Viewed by 194 | Submission Open
Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy
(This special issue belongs to the Section Cancer Therapy)
Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease
edited by
submission deadline 31 May 2026 | Viewed by 191 | Submission Open
Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy; quality of life; and prognosis
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms submission deadline 31 May 2026 | Viewed by 161 | Submission Open
Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
Mutagenesis and DNA Methylation in Aging
edited by Steven S. Smith
submission deadline 31 May 2026 | Viewed by 158 | Submission Open
Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns
(This special issue belongs to the Section Molecular Cancer Biology)
The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine
edited by Aftab Alam
submission deadline 31 May 2026 | Viewed by 156 | Submission Open
Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Infectious Agents and Oesophageal Cancer (2nd Edition)
edited by and Mohammed Rabiei
submission deadline 31 May 2026 | Viewed by 151 | Submission Open
Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma
(This special issue belongs to the Section Infectious Agents and Cancer)
Head and Neck Cancer: MRI and PET/CT Diagnosis and Surgical Treatment submission deadline 31 May 2026 | Viewed by 141 | Submission Open
Keywords: head and neck cancer; MRI; PET/CT; diagnostic imaging; surgical treatment; tumor staging; image-guided surgery; multidisciplinary approach; oncologic outcomes
(This special issue belongs to the Section Cancer Therapy)
Single-Cell and Spatial Data Analytics in Cancers
edited by and Qi Liu
submission deadline 31 May 2026 | Viewed by 131 | Submission Open
Keywords: single-cell and spatial omics; tumor heterogeneity; tumor progression; tumor microenvironment; cancer immunotherapy
(This special issue belongs to the Section Cancer Informatics and Big Data)
Image-Guided Radiotherapy in Head and Neck Cancer
edited by Petar Suton
submission deadline 31 May 2026 | Viewed by 126 | Submission Open
Keywords: image-guided radiotherapy (IGRT); head and neck cancer; radiation therapy; cone-beam CT (CBCT); adaptive radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Role of Cytokines in Cancer (2nd Edition) submission deadline 31 May 2026 | Viewed by 121 | Submission Open
Keywords: inflammation; tumor microenvironment; cytokines
(This special issue belongs to the Section Tumor Microenvironment)
Targeted Therapy in Gastrointestinal Cancer (2nd Edition)
edited by and
submission deadline 31 May 2026 | Viewed by 116 | Submission Open
Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development
(This special issue belongs to the Section Cancer Therapy)
Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma
edited by
submission deadline 31 May 2026 | Viewed by 115 | Submission Open
Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies
(This special issue belongs to the Section Clinical Research of Cancer)
Clinical Imaging and Immunotherapy in Cancer Research
edited by
submission deadline 31 May 2026 | Viewed by 115 | Submission Open
Keywords: immunotherapy; immune checkpoint inhibitors; molecular imaging; tumor microenvironment; artificial intelligence (AI); radiomics
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Microenvironment in Ovarian Cancer Progression, Dissemination, Recurrence: Biology and Therapeutic Opportunities submission deadline 31 May 2026 | Viewed by 106 | Submission Open
Keywords: transperitoneal carcinomatosis; malignant ascites; chemoresistance; metabolic adaptations; regulation of immune response; tumor– stroma interaction; tumor– peritoneal interaction
(This special issue belongs to the Section Tumor Microenvironment)
Three-Dimensional In Vitro Modeling for the Study of Epithelial Cancers
edited by and George Wai Cheong Yip
submission deadline 31 May 2026 | Viewed by 103 | Submission Open
Keywords: 3D cancer model; 3D cancer stem cell culture; 3D tumor invasion model; cancer-on-a-chip; cancer spheroids; carcinogenesis organoid model; bioprinted cancer tissue; microfluidic platform for cancer; scaffold-based cancer model
(This special issue belongs to the Section Methods and Technologies Development)
The Pathogenesis and Treatment of Diffuse Midline Glioma submission deadline 31 May 2026 | Viewed by 85 | Submission Open
Keywords: pediatric brain tumors; diffuse midline glioma; high-grade glioma; H3K27M mutant glioma; liquid biopsy; diffuse intrinsic pontine glioma
(This special issue belongs to the Section Cancer Therapy)
Cellular Senescence, Aging and the Tumor Microenvironment in Cancer
edited by Jabed Iqbal and Jeremy Wee Kiat Ng
submission deadline 31 May 2026 | Viewed by 68 | Submission Open
Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Urological Cancer: Innovative Therapies and Biomarkers
edited by Hiroshi Yaegashi
submission deadline 31 May 2026 | 1 articles | Viewed by 63 | Submission Open
Keywords: urological oncology; urothelial cancer; prostate cancer; renal cancer; biomarkers; immunotherapy
Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine submission deadline 31 May 2026 | Viewed by 58 | Submission Open
Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer
(This special issue belongs to the Section Methods and Technologies Development)
The Advance of Proton Therapy in Head-and-Neck Cancers
edited by and Edward Christopher Dee
submission deadline 31 May 2026 | Viewed by 56 | Submission Open
Keywords: proton therapy; head-and-neck cancer; clinical outcomes; toxicity reduction; multinational studies; reirradiation; skull base tumors; salivary gland cancers; prospective and retrospective cohorts
(This special issue belongs to the Section Cancer Therapy)
Role of Protein and Metabolite in Cancers
edited by
submission deadline 31 May 2026 | Viewed by 55 | Submission Open
Keywords: cancer progression; cancer cells; proteins; metabolites; signaling pathway; metabolic dysregulations
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Primary and Secondary Bone and Soft Tissue Tumors
edited by
submission deadline 31 May 2026 | Viewed by 52 | Submission Open
Keywords: primary bone tumors; soft tissue sarcomas; metastatic bone disease; molecular diagnostics including liquid biopsy; surgical management including reconstruction; immunotherapy; tumor microenvironment; biomarkers and prognostic factors; cancer surveillance; translational oncology
Noncoding RNA and Molecular Mechanisms of Metastasis in Gastrointestinal Cancers
edited by
submission deadline 31 May 2026 | Viewed by 51 | Submission Open
Keywords: noncoding RNA; gastrointestinal cancers; metastasis; molecular mechanisms; microRNA; long noncoding RNA; circular RNA; cancer biology; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Treatment and Translational Advances in Myelodysplastic Syndromes and Acute Myeloid Leukemia submission deadline 31 May 2026 | Viewed by 47 | Submission Open
Keywords: myeloid neoplasms; myelodysplastic neoplasms; acute myeloid leukemia; leukemogenesis; target therapy
Innovations in Colorectal Cancer
edited by Sandy Hwang Fang
submission deadline 31 May 2026 | Viewed by 46 | Submission Open
Keywords: colon cancer; rectal cancer; innovation; clinical trials; total neoadjuvant therapy; medical oncology; radiation oncology
Neuroimaging Biomarkers of Cancer Therapy-Related CNS Complications
edited by Jasmina Boban
submission deadline 31 May 2026 | Viewed by 46 | Submission Open
Keywords: neuroimaging; multimodal imaging; chemotherapy; immunotherapy; chemotherapy-related cognitive dysfunction; drug- related side effects and adverse reactions
Toxicities of Antineoplastic Therapies
edited by Ysabella Van Sebille, and
submission deadline 31 May 2026 | Viewed by 44 | Submission Open
Keywords: antineoplastic therpay; cancer treatment-related toxicities; cancer treatment adverse events; chemotherapy toxicity; targeted therapy toxicities; immunotherapy toxicity; hormonal therapy toxicity; radiation-induced toxicity; cellular and gene therapy toxicity; supportive cancer care; survivorship; patient-reported outcomes; toxicity management
(This special issue belongs to the Section Cancer Therapy)
Gynecological Cancers: Molecular Insights to Precision Therapy
edited by Gian Franco Zannoni and
submission deadline 31 May 2026 | Viewed by 42 | Submission Open
Keywords: gynecological cancers; precision medicine; molecular biomarkers; targeted therapy; tumor microenvironment; immunotherapy; translational oncology
The Evolving Role of CDK4/6 Inhibitors in Early and Recurrent Breast Cancer: Clinical and Translational Findings and Work in Progress
edited by Hans-Christian Kolberg
submission deadline 31 May 2026 | Viewed by 37 | Submission Open
Keywords: CDK4/6 inhibitors; breast cancer; treatment resistance; combination therapy; biomarkers
Multiple Myeloma: From Molecular Insights to Clinical Treatments
edited by Mikala Gabor
submission deadline 31 May 2026 | Viewed by 37 | Submission Open
Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation
Evolving Role of Surgery in Thoracic Oncology
edited by Inderpal S. Sarkaria and Shamus Carr
submission deadline 31 May 2026 | Viewed by 35 | Submission Open
Keywords: non-small cell lung cancer; esophageal cancer; thymic epithelial tumors; BAP1 malignant mesothelioma; robotic surgery; immunotherapy; cellular therapies; molecular imaging
T-Cell Lymphoma: From Diagnosis to Treatment
edited by Lubomir Sokol and Yumeng Zhang
submission deadline 31 May 2026 | Viewed by 34 | Submission Open
Keywords: cutaneous T-cell lymphomas (CTCLs); peripheral T-cell lymphomas (PTCLs); Sezary syndrome (SS); mycosis fungoides (MF); genetic; epigenetic; therapeutic strategies
Epigenetic Alterations in Human Tumors
edited by Mihalis I. Panayiotidis and
submission deadline 31 May 2026 | Viewed by 32 | Submission Open
Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Multimodality Imaging for More Precise Radiotherapy (2nd Edition)
edited by Stefano Arcangeli, and
submission deadline 31 May 2026 | Viewed by 31 | Submission Open
Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Flow Cytometry in Acute Leukemia: From Diagnosis to Disease Monitoring submission deadline 31 May 2026 | Viewed by 31 | Submission Open
Keywords: acute leukemia; ALL; AML; flow cytometry; NGF; leukemia stem cells (LSCs; minimal residual disease (MRD)
(This special issue belongs to the Section Methods and Technologies Development)
Adjuvant Therapy and The Cytotoxic Effects in Colorectal Cancers
edited by William H. Gmeiner
submission deadline 31 May 2026 | Viewed by 29 | Submission Open
Keywords: colorectal cancer; adjuvant chemotherapy; targeted therapy; immunotherapy; metastatic colorectal cancer; drug resistance; combination therapy; cytotoxic effects
(This special issue belongs to the Section Cancer Therapy)
Machine Learning and Artificial Intelligence in Leukemia
edited by Garrett M. Dancik and
submission deadline 31 May 2026 | Viewed by 29 | Submission Open
Keywords: cancer genomics; genomic sequencing; biomarkers; predictive modeling; machine learning; artificial intelligence; leukemia; computer vision; natural language processing
(This special issue belongs to the Section Methods and Technologies Development)
The Intelligent Scalpel: AI and the Future of Cancer Surgery
edited by Abdallah S. Attia and Kristen E. Limbach
submission deadline 31 May 2026 | Viewed by 27 | Submission Open
Keywords: artificial intelligence; surgical oncology; radiomics; pathomics; robotic surgery; large language models; multimodal learning; explainable AI; precision surgery; ethical AI
(This special issue belongs to the Section Methods and Technologies Development)
Breast Cancer and Hormone-Related Therapy: 2nd Edition
edited by
submission deadline 31 May 2026 | Viewed by 19 | Submission Open
Keywords: breast cancer; estrogen receptor; hormone activated transcription factors; hormonal therapy; molecular mechanisms
(This special issue belongs to the Section Cancer Therapy)
What’s Behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification (2nd Edition)
edited by
submission deadline 31 May 2026 | Viewed by 16 | Submission Open
Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Updates on Progress in Stem-Cell Transplantation in Cancer Patients
edited by Nidhi Jyotsana
submission deadline 31 May 2026 | Viewed by 9 | Submission Open
Keywords: hematopoietic stem cell transplantation (HSCT); acute myeloid leukemia (AML); leukemic stem cells; optimize transplant protocols
(This special issue belongs to the Section Transplant Oncology)
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