Decoding the Dynamic Matrix Complexity in Cancer

Dear Colleagues,

Extracellular matrices (ECMs) are highly dynamic three-dimensional (3D) structural and cell regulatory meshworks of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, elastin, (glyco)proteins, and matrix-degrading enzymes. Matrix macromolecules are characterized by high structural complexity and heterogeneity. They form complex networks through which they dynamically communicate with cells and shape the complex tumor microenvironment. ECMs are not merely structural components, but rather active and critical regulators of several homeostatic and pathological processes, such as cancer. Their molecular composition varies among different tissues and undergoes significant modifications and remodeling during cancer progression. The elucidation of the mechanistic aspects governing matrix assembly and modifications, as well as cell–cell and cell–matrix interactions, is of critical importance to fully understand cancer pathobiology and to identify tumor biomarkers and novel therapeutic targets. Moreover, 3D cell culture models and bioscaffolds that mimic native ECM architecture and biophysical properties have emerged as powerful tools to investigate cell–matrix crosstalk and the dynamic interactions within the tumor microenvironment. This Special Issue of Cancers seeks to highlight the roles of effective matrix macromolecules, including matrix remodeling enzymes, PGs/GAGs, specific types of collagens and matrix (glyco)proteins, the modeling of tumor microenvironment complexity as well as the mechanisms underlying the dynamic cancer-associated cell–matrix interactions that drive cancer development and aggressiveness.

We invite submissions of original research articles and reviews that address topics that include but are not limited to the following, which are aligned with the aim of decoding dynamic matrix complexity:

• Proteoglycans and Glycosaminoglycans as Dynamic Regulators of Tumor Plasticity
• Targeting Matrix Remodeling Enzymes in Cancer Progression
• Collagen and Glycoprotein Networks as Biomarkers and Therapeutic Targets
• Cell Surface Matrix Receptors and Effectors in Pre-metastatic Niche Formation
• Matrix-Derived Bioscaffolds for Modeling Tumor Microenvironment Complexity
• 3D Cell Culture Models in Mimicking Tumor Microenvironment

Should you have any questions, require further information, or need any assistance, please do not hesitate to reach out to us. We are happy to support and facilitate your participation.

Thank you for your interest in this Special Issue. We look forward to your contributions.

Prof. Dr. Nikos Karamanos
Prof. Dr. Zoi Piperigkou
Prof. Dr. Luisa Bracci
Guest Editors

Manuscript Submission Information

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