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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oncology: State-of-the-Art Research and Initiatives in Japan submission deadline 31 Dec 2025 | 8 articles | Viewed by 17146 | Submission Open
Keywords: Japan; cancer; oncology; research; clinical trial; survivorship; patient support
Integrating Palliative Care in Oncology submission deadline 31 Dec 2025 | 9 articles | Viewed by 15249 | Submission Open
Keywords: early palliative care; advanced cancer; complexity of care needs; integration of palliative care in oncology; cancer pain; symptom control; end-of-life; advance care planning
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Novel Therapeutic Strategies in Salivary Gland Tumor submission deadline 31 Dec 2025 | 8 articles | Viewed by 14983 | Submission Open
Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging
(This special issue belongs to the Section Cancer Therapy)
Advanced Diagnostics and Optical Imaging Technologies in Cancer Research
edited by Vlad Mihai Voiculescu
submission deadline 31 Dec 2025 | 9 articles | Viewed by 14885 | Submission Open
Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Biology, Diagnosis and Management of Cervical Cancer
edited by , , Thomas Vrekoussis and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 13487 | Submission Open
Keywords: cervical cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Chronic Lymphocytic Leukaemia (CLL) Research
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 12195 | Submission Open
Keywords: chronic lymphocytic leukaemia; CLL; aetiology; oncogenic transformation; survival; cure
(This special issue belongs to the Section Cancer Therapy)
New Perspectives in the Management of Breast Cancer submission deadline 31 Dec 2025 | 9 articles | Viewed by 11703 | Submission Open
Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact
(This special issue belongs to the Section Cancer Therapy)
Oral Potentially Malignant Disorders and Oral Cavity Cancer
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 11475 | Submission Open
Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine
(This special issue belongs to the Section Cancer Therapy)
Medical Imaging and Artificial Intelligence in Cancer
edited by Debiao Li and
submission deadline 31 Dec 2025 | 9 articles | Viewed by 8601 | Submission Open
Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization
(This special issue belongs to the Section Methods and Technologies Development)
Surgery for Colorectal Cancer submission deadline 31 Dec 2025 | 6 articles | Viewed by 7647 | Submission Open
Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer
(This special issue belongs to the Section Cancer Therapy)
State-of-the-Art Treatment on Chemotherapy and Immunotherapy for Urological Cancer
edited by and Hiroshi Yaegashi
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7574 | Submission Open
Keywords: chemotherapy; immunotherapy; antibody– drug conjugate; radioligand therapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; urachal cancer; penile cancer; adrenal cancer; sarcoma; clinical trial; basic research
(This special issue belongs to the Section Tumor Microenvironment)
Updates in Neuroendocrine Neoplasms
edited by Jonathan Strosberg
submission deadline 31 Dec 2025 | 6 articles | Viewed by 7432 | Submission Open
Keywords: neuroendocrine tumors; neuroendocrine neoplasms; neuroendocrine carcinomas; therapy; germline mutations; somatic mutations
(This special issue belongs to the Section Cancer Therapy)
Lymph Node Dissection for Gynecologic Cancers
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6518 | Submission Open
(This special issue belongs to the Section Methods and Technologies Development)
Technological Development for Advances in Cancer Research and Precision Oncology
edited by , and Fenglong Ma
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6164 | Submission Open
Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics
(This special issue belongs to the Section Molecular Cancer Biology)
Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 5953 | Submission Open
Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion
(This special issue belongs to the Section Cancer Biomarkers)
Ovarian Cancer Stem Cells and Tumor Microenvironment
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5799 | Submission Open
Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts
(This special issue belongs to the Section Tumor Microenvironment)
The Applications of Artificial Intelligence in Gastroenterology
edited by , and Louis H. S. Lau
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5721 | Submission Open
Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases
(This special issue belongs to the Section Cancer Therapy)
Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets submission deadline 31 Dec 2025 | 3 articles | Viewed by 5365 | Submission Open
Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction
(This special issue belongs to the Section Cancer Therapy)
Advancements in Head and Neck Cancer Surgery submission deadline 31 Dec 2025 | 4 articles | Viewed by 5196 | Submission Open
Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Surgical Treatment of Urinary Tumors
edited by Pierre I. Karakiewicz and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4996 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology
(This special issue belongs to the Section Cancer Therapy)
Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics submission deadline 31 Dec 2025 | 2 articles | Viewed by 4438 | Submission Open
Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications
(This special issue belongs to the Section Cancer Therapy)
Robotic Surgery in Colorectal Cancer
edited by James Chi Yong Ngu
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4294 | Submission Open
Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Radiation Therapy for Head and Neck Cancer submission deadline 31 Dec 2025 | 4 articles | Viewed by 4028 | Submission Open
Keywords: adaptive radiotherapy  ; hyper- and hypo-fractionated radiotherapy  ; artificial intelligence in radiotherapy for head and neck cancer  ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques  ; protons and heavy ions for radiotherapy  ; re-irradiation  ; nanoparticles plus radiotherapy  ; hyperthermia plus radiotherapy  ; radiotherapy plus immunotherapy  ; the de-escalation of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Clear Cell Renal Cell Carcinoma 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 4011 | Submission Open
Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Feature Papers in Section "Tumor Microenvironment"
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3948 | Submission Open
Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2024–2025
edited by and David R. Gandara
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3730 | Submission Open
Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Artificial Intelligence-Assisted Radiomics in Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3602 | Submission Open
Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Physiotherapy in Advanced Cancer and Palliative Care
edited by Nele Adriaenssens
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3510 | Submission Open
Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Enhancing Cancer Treatments through Fluorescence-Guided Surgery
edited by Ibrahim Khot and Yazan Sulaiman Khaled
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3495 | Submission Open
Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Spine Oncology: Research and Clinical Studies
edited by Oluwaseun O. Akinduro
submission deadline 31 Dec 2025 | 5 articles | Viewed by 3422 | Submission Open
Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy
(This special issue belongs to the Section Clinical Research of Cancer)
Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3172 | Submission Open
Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology
(This special issue belongs to the Section Methods and Technologies Development)
Immunotherapy in Non-Small Cell Lung Cancers
edited by Marco Russano
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3013 | Submission Open
Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Recent Advances in Non-muscle Invasive Bladder Cancer
edited by Paul L. Crispen
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2813 | Submission Open
Keywords: non-muscle invasive bladder cancer; adjuvant therapy; surveillance; BCG refractory; intravesical therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Hereditary and Familial Colorectal Cancer
edited by Bryson W. Katona and Peter P. Stanich
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2749 | Submission Open
Keywords: hereditary colorectal cancer; familial colorectal cancer; genetic predisposition; polyposis; Lynch syndrome; familial adenomatous polyposis (FAP); MUTYH-associated polyposis (MAP); genetic testing
(This special issue belongs to the Section Cancer Pathophysiology)
Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Urological Tumours
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2679 | Submission Open
Keywords: urological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Sequence Variants in Breast/Ovarian Cancer Susceptibility Genes: From Risk Assessment to Clinical Management in Carrier Individuals and Their Blood Relatives
edited by Arcangela De Nicolo and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2582 | Submission Open
Keywords: breast/ovarian cancer susceptibility genes; risk assessment and clinical management of carrier individuals and their blood relatives; risk models; variant classification; multifactorial approaches
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Use of PET/CT and MRI in Prostate Cancer
edited by Carmelo Caldarella
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2531 | Submission Open
Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
Chemotherapy and Immunotherapy of Lung Cancer
edited by and Klaus Hackner
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2384 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy; lung cancer; programmed-death ligand; chemoimmunotherapy; non-small-cell lung cancer; small-cell lung cancer
(This special issue belongs to the Section Cancer Therapy)
Precision Oncology for Rare Skin Cancers
edited by Gino K. In and Aparna Nallagangula
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2269 | Submission Open
Keywords: rare skin cancers; melanoma; cutaneous squamous cell carcinoma; basal cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma; adnexal/sweat gland carcinoma; dermatofibrosarcoma protuberans; extramammary Paget’ s disease; cutaneous sarcomas
(This special issue belongs to the Section Molecular Cancer Biology)
New Insights into Kidney Disease Development and Therapy Strategies submission deadline 31 Dec 2025 | 1 articles | Viewed by 2089 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
New Perspectives in the Management of Central Nervous System (CNS) Tumors
edited by , Francesco Bruno and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2065 | Submission Open
Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors
(This special issue belongs to the Section Cancer Therapy)
Feature Papers in Section “Cancer Informatics and Big Data”
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2028 | Submission Open
Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics
(This special issue belongs to the Section Cancer Informatics and Big Data)
Advances in Breast and Gynecologic Cancer Pathology: Molecular Insights and Therapeutic Implications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1992 | Submission Open
Keywords: breast cancer; gynecologic malignancies; diagnostic pathology; molecular biomarkers; histopathology; cytopathology; prognostic markers; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Fertility Preservation in Gynecological Cancer submission deadline 31 Dec 2025 | 1 articles | Viewed by 1826 | Submission Open
Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication
(This special issue belongs to the Section Methods and Technologies Development)
Perspectives on the Efficacy and Biomarkers of Immunotherapy and Targeted Therapy for Patients with Colorectal Cancer submission deadline 31 Dec 2025 | 1 articles | Viewed by 1760 | Submission Open
Keywords: colorectal cancer; precision medicine; targeted therapeutics; immunotherapy; KRAS; BRAF; HER2; biomarkers
(This special issue belongs to the Section Cancer Therapy)
The Advance of Biomarker-Driven Targeted Therapies in Cancer
edited by , Qiushi Wang and Ann Bode
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1523 | Submission Open
Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy
(This special issue belongs to the Section Cancer Therapy)
New Insights in the Management of Resectable Esophageal Malignancy
edited by and Dimitrios A. Theodorou
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1514 | Submission Open
Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Pancreatic Ductal Adenocarcinoma Diagnosis and Treatment 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1474 | Submission Open
Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; genetic changes; genomics; surgical resection; radiotherapy; radiochemotherapy; chemotherapy; targeted therapy; immunotherapy; resectable tumor; borderline resectable tumor; metastatic disease; nutritional treatment; quality of life
(This special issue belongs to the Section Cancer Therapy)
Advances in Ovarian Cancer Treatment: Past, Present and Future
edited by Dimitrios Tsolakidis and Dimitrios Zouzoulas
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1158 | Submission Open
Keywords: ovarian cancer; cytoreductive surgery; HIPEC; chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape
edited by Jon Mallen-St Clair
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1041 | Submission Open
Keywords: oropharyngeal cancer; human papillomavirus; clinical trials; transoral robotic surgery; epidemiology; HPV-related oropharyngeal cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
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