Current Advances in Management of Neuroendocrine Neoplasms

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 603

Special Issue Editors


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Guest Editor
1. Department of Surgery & Cancer, Imperial College London, London SW7 2BX, UK
2. Cancer Research UK Oxford Centre, University of Oxford, Oxford OX1 2JD, UK
Interests: neuroendocrine tumours; epidemiology; clinical prediction models; statistical and machine learning in healthcare

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Guest Editor
Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK
Interests: neuroendocrine tumours; hepato-pancreato-biliary tumours; liver metastases; multimodal treatment; personalised medicine; novel biomarkers

Special Issue Information

Dear Colleagues,

Neuroendocrine neoplasms (NENs) are relatively rare yet profoundly clinically challenging tumours. Despite progress over the past 10-15 years manifesting as the first randomised clinical trials, the increasing centralisation of care in centres of excellence, and impressive gains in best standards of imaging, there remains significant scope for advancing the management of people with NENs.

This Special Issue seeks to highlight these advances and their routes to improving clinical care. We welcome submissions of original research and cutting edge reviews on topics that summarise modern developments in topics including, but not limited to:

  • Epidemiology of NETs (pre- and/or post-diagnosis);
  • Advances in diagnostics;
  • New concepts or evidence regarding treatment strategies;
  • Novel biomarkers;
  • Artificial intelligence/machine learning.

This Special Issue will not only anticipate but define the near-future state of the art for NEN.

Dr. Ashley Kieran Clift
Prof. Dr. Andrea Frilling
Guest Editors

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Keywords

  • neuroendocrine tumours
  • epidemiology
  • clinical prediction models
  • machine learning
  • personalised medicine
  • novel biomarkers
  • diagnostics
  • treatment
  • artificial intelligence

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Published Papers (1 paper)

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Review

16 pages, 1663 KiB  
Review
Advances in Molecular Imaging for Neuroendocrine Neoplasms
by Bradley Girod and Vikas Prasad
Cancers 2025, 17(12), 2013; https://doi.org/10.3390/cancers17122013 - 17 Jun 2025
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Abstract
Neuroendocrine neoplasms (NENs) represent a heterogenous group of tumors with significant inter- and intra-patient variability. Once considered to be rare, neuroendocrine neoplasms are being increasingly recognized through the advent of advanced diagnostic techniques, which may be contributing to the significant increase in the [...] Read more.
Neuroendocrine neoplasms (NENs) represent a heterogenous group of tumors with significant inter- and intra-patient variability. Once considered to be rare, neuroendocrine neoplasms are being increasingly recognized through the advent of advanced diagnostic techniques, which may be contributing to the significant increase in the incidence and detection rate of these tumors. NENs can be classified into well differentiated and poorly differentiated neuroendocrine tumors (NETs) or neuroendocrine carcinomas (NECs). The proliferation rate of NETs can vary from Ki-67 1–55%. In addition, the SSTR expression can vary significantly. Because of this high “heterogeneity”, their detection and characterization have become essential to disease management, leading to dual-tracer imaging, most commonly with FDG- and SSTR-targeted PET/CT. Because of the complexity of the disease, the optimal treatment of patients depends on a combination of imaging, serological biomarkers, and clinical information. There remains a significant portion of patients who do not respond as anticipated, and the management of their disease remains challenging with current techniques, necessitating the refinement of our technologies and the development of new ones. In addition to new biological targets, improved peptide vector targeting for the somatostatin receptor needs further development. This review aims to evaluate the existing imaging techniques utilized in the diagnosis, assessment, and treatment of NENs, as well as the emerging radiopharmaceuticals and technologies, which will expand our imaging repertoire as well as our management options. Full article
(This article belongs to the Special Issue Current Advances in Management of Neuroendocrine Neoplasms)
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