Colorectal Cancer: Risk Factors and Underlying Mechanisms
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".
Deadline for manuscript submissions: 25 May 2026 | Viewed by 729
Special Issue Editor
Special Issue Information
Dear Colleagues,
Colorectal cancer (CRC) is the third most common cancer globally, with 1.9 million new cases in 2022 and an estimated 3.2 million by 2045. Its risk is influenced by genetic, lifestyle, and environmental factors. Obesity, smoking, alcohol, physical inactivity, and diets high in red or processed meat increase risk, while fiber, fruits, vegetables, dairy, and whole grains may be protective. Environmental exposures, including pollutants and diet-related chemicals, can alter the gut microbiome, contributing to CRC development. These factors may interact synergistically or antagonistically, involving mechanisms such as inflammation, genetic/epigenetic instability, and metabolic dysregulation. Promoting a healthy lifestyle and early screening is essential for effective CRC prevention and reducing its global burden.
Dr. David Achaintre
Guest Editor
Manuscript Submission Information
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Keywords
- colorectal cancer
- diet
- environmental factors
- microbiome
- inflammation
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