cancers-logo

Journal Browser

Journal Browser

Advances in Endometrial Cancer Prevention, Early Diagnosis and Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 325

Special Issue Editor


E-Mail Website
Guest Editor
Division of Cancer Sciences, The University of Manchester, Manchester, UK
Interests: endometrial cancer; surgery; advanced therapy; molecular classification; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The rising global incidence of endometrial cancer means that more women than ever are living with and, unfortunately, also dying from this disease. Whilst surgery in combination with radio- and chemotherapy has long been the cornerstone of endometrial cancer treatment, increasing knowledge of endometrial cancer biology has ensured the success of fertility-sparing approaches and enabled the personalisation of care. The molecular characterisation of tumours and clinical trials of immunotherapies are set to revolutionise how we manage the disease as we move towards improving disease control whilst minimising treatment side effects.

This Special Issue aims to highlight the recent advances in the prevention, early diagnosis, and treatment of early and advanced/recurrent endometrial cancer and answer any outstanding research questions. Both original research articles and review papers are welcome to be submitted to this Special Issue.

Dr. Sarah J. Kitson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrial cancer
  • gynaecologic oncology
  • surgery
  • prevention
  • early diagnosis
  • advanced therapy
  • molecular classification
  • biomarkers

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 3105 KB  
Article
Targeting ATR and PI3Kα Pathways Promotes Ferroptosis in PIK3CA-Wildtype Platinum-Resistant Endometrial Cancer
by Chi-Ting Shih, Kristen R. Ibanez, Jung-Min Lee and Tzu-Ting Huang
Cancers 2026, 18(7), 1064; https://doi.org/10.3390/cancers18071064 (registering DOI) - 25 Mar 2026
Viewed by 120
Abstract
Background/Objectives: Platinum resistance in endometrial cancer (EC) remains a significant therapeutic challenge, as tumors frequently bypass apoptotic cell death. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, offers an alternative mechanism to target apoptosis-resistant cancers. This study evaluated whether [...] Read more.
Background/Objectives: Platinum resistance in endometrial cancer (EC) remains a significant therapeutic challenge, as tumors frequently bypass apoptotic cell death. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, offers an alternative mechanism to target apoptosis-resistant cancers. This study evaluated whether combined inhibition of ATR and PI3Kα could induce cell death in platinum-resistant EC through apoptotic or ferroptotic pathways. Methods: A panel of EC cell lines, including patient-derived models with varying PIK3CA mutation status and platinum sensitivity, was treated with camonsertib (ATR inhibitor) and inavolisib (PI3Kα inhibitor). Cell death mechanisms were assessed through DNA damage indicators (γH2AX, comet assay, DNA fiber analysis), apoptosis markers (Annexin V, cleaved PARP, cleaved caspase 3), and ferroptosis markers (FerroOrange, xCT expression, redox homeostasis). Results: While monotherapies showed limited activity, dual ATR and PI3Kα inhibition produced additive/synergistic cytotoxicity across all EC cell lines, independent of platinum sensitivity or microsatellite stability status. Mechanistically, the treatment induced genotype-specific cell death: PIK3CA-mutant cells underwent apoptosis driven by catastrophic DNA damage accumulation, whereas PIK3CA-wildtype cells exhibited predominantly ferroptosis characterized by xCT downregulation and redox disruption. Conclusions: Our findings establish dual ATR and PI3Kα inhibition as a genotype-informed therapeutic strategy for platinum-resistant EC. PIK3CA mutation status may influence the mode of cell death, supporting its use as a predictive biomarker for patient stratification in future clinical applications. Full article
Show Figures

Figure 1

Back to TopTop