Clinical Advances and State-of-Art Management in Genitourinary Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 1527

Special Issue Editors


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Guest Editor
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Interests: genitourinary cancers; tumor immune microenvironment; cancer immunology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Interests: genitourinary cancers; tumor immune microenvironment; cancer immunology

Special Issue Information

Dear Colleagues,

Genitourinary (GU) malignancies represent a variety of tumors within the urinary and male reproductive systems, requiring individualized treatment plans to meet the distinct needs of each patient. Although most GU malignancies are well managed in the early stages, the advanced stages of many such cancers have a poor prognosis. Limited treatment options and poor prognosis represent an unmet need in advanced GU malignancies.

The development of novel therapies for advanced GU cancers relies on comprehension of underlying biological mechanisms, and several research efforts have focused on genomic profiling, diagnostic biomarkers, tumor immune microenvironment (TIME), and molecular pathways of oncogenesis.

The focus of this Special Issue is to consider research efforts pertaining to: (a) tumor biology, genomic characterization, and microenvironment; and (b) exploration of novel therapies in genitourinary malignancies.

Dr. Jad Chahoud
Guest Editor

Dr. Adnan Fazili
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • genitourinary malignancies
  • tumor–immune microenvironment (TIME)
  • tumor biology
  • genomic characterization
  • targeted drug therapy
  • immunotherapy

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Published Papers (1 paper)

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Research

13 pages, 953 KiB  
Article
Paraneoplastic Resolution Holds Prognostic Utility in Patients with Metastatic Renal Cell Carcinoma
by Gregory Palmateer, Edouard H. Nicaise, Taylor Goodstein, Benjamin N. Schmeusser, Dattatraya Patil, Nahar Imtiaz, Daniel D. Shapiro, Edwin J. Abel, Shreyas Joshi, Vikram Narayan, Kenneth Ogan and Viraj A. Master
Cancers 2024, 16(21), 3678; https://doi.org/10.3390/cancers16213678 - 30 Oct 2024
Cited by 1 | Viewed by 1201
Abstract
Background/Objectives: The presence of paraneoplastic syndromes (PNS) in patients with renal cell carcinoma (RCC) is associated with worse survival; however, little is known about whether resolution of PNS after intervention has any prognostic value. We sought to determine if resolution of PNS by [...] Read more.
Background/Objectives: The presence of paraneoplastic syndromes (PNS) in patients with renal cell carcinoma (RCC) is associated with worse survival; however, little is known about whether resolution of PNS after intervention has any prognostic value. We sought to determine if resolution of PNS by one year after cytoreductive nephrectomy was significantly associated with improved overall survival (OS) and cancer-specific survival (CSS). Methods: We retrospectively reviewed a prospectively maintained nephrectomy database for patients with any histology metastatic RCC (mRCC) who underwent nephrectomy between 2000 and 2022. Patients with the necessary laboratory studies available within 90 days before and by one year after surgery were included for study. PNS resolution was defined as an abnormal value compared to established laboratory cutoffs by one year after surgery. Multiple PNS in one patient was allowed, and resolution of each PNS was measured separately. OS and CSS were assessed using Kaplan–Meier curves and Cox proportional hazards models. Results: A total of 253 patients met inclusion criteria. A total of 177 patients (70.0%) met criteria for at least one PNS resolution by one year. Five-year OS and CSS rates were 15.7% and 36.2% for no PNS resolved, 24.5% and 31.6% for 1 PNS resolved, and 43.0% and 58.2% for ≥2 PNS resolved, respectively (p < 0.001). On multivariable analysis, no PNS resolution was associated with worse OS (HR 2.75, p < 0.001) and CSS (HR 2.62, p < 0.001) compared to ≥2 PNS resolved. Conclusions: Resolution of preoperative PNS abnormalities by one year following surgery is associated with improved OS and CSS in patients with mRCC. Full article
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