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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Outcomes in Urologic Cancers
edited by and Pierre Karakiewicz
submission deadline 15 Nov 2025 | 19 articles | Viewed by 49177
Keywords: bladder cancer; prostate cancer; kidney cancer; upper tract urothelial carcinoma; adrenocortical cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Breast Cancer: Biomarkers of Diagnosis and Prognosis
edited by and Sarah J. Storr
submission deadline 15 Nov 2025 | 9 articles | Viewed by 19965
Keywords: breast cancer; biomarker; diagnosis; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Brain Metastases: From Mechanisms to Treatment
edited by Dawen Zhao and Michael Chan
submission deadline 15 Nov 2025 | 7 articles | Viewed by 15322
Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy
(This special issue belongs to the Section Cancer Metastasis)
Benign and Malignant Neoplasms of the Head and Neck
edited by Charles C. L. Tong and Brett A. Miles
submission deadline 15 Nov 2025 | 4 articles | Viewed by 12523
Keywords: laryngeal cancer; oral cavity and oropharynx cancer; nasal cavity and paransal sinus cancer; anterior and lateral skull base cancer; salivary gland cancer; melanoma
(This special issue belongs to the Section Cancer Therapy)
Immune-Related Adverse Events in Cancer Immunotherapy
edited by Kate Young and Anna Olsson-Brown
submission deadline 15 Nov 2025 | 5 articles | Viewed by 12430
Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Overcoming Pitfalls in the Detection and Definition of Clinically Significant Prostate Cancer: Strategies to Improve Screening and Diagnosis
edited by
submission deadline 15 Nov 2025 | 2 articles | Viewed by 6232
Keywords: prostate cancer; PSA; magnetic resonance of the prostate; prostatic tissue-based biomarkers; prostate biopsy; prostate cancer screening
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Radiotherapy for Thoracic Malignancies: New Advances and Challenges: 2nd Edition
edited by
submission deadline 15 Nov 2025 | 3 articles | Viewed by 4517
Keywords: radiotherapy; stereotactic body radiation therapy; non-small cell lung cancer; immunotherapy; thoracic oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in Therapeutic Approaches Targeting Pediatric and Adult Glioma
edited by Siddhartha Mitra and
submission deadline 15 Nov 2025 | 1 articles | Viewed by 3766
Keywords: glioma; high-grade glioma; glioblastoma; DIPG; ependymoma; immunotherapy; targeted therapy; combination therapies; small-molecule inhibitors
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiomic, Genomic and Radiogenomic Techniques in Pediatric Medulloblastoma
edited by Marwa Ismail
submission deadline 15 Nov 2025 | 1 articles | Viewed by 2676
Keywords: medulloblastoma; pediatrics; radiomics; genomics; segmentation; deep learning; classification; risk-stratification; molecular subgroups
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Trachea, Bronchus and Lung Cancer Management: 2nd Edition
edited by , Dionisios G. Spyratos and
submission deadline 15 Nov 2025 | 1 articles | Viewed by 1016
Keywords: trachea; bronchus and lung cancer; non-small cell lung cancer (NSCLC); small cell lung cancer (SCLC); cancer management; clinical suspicion; diagnosis; treatment; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Nanomedicine and Nanobiotechnology in Cancer submission deadline 15 Nov 2025 | Viewed by 632
Keywords: nanomedicine; nanobiotechnology; nanodevices; nanoimaging; 3D models; drug delivery; nanotechnologies for translational medicine; pre-clinical and clinical phases; from bench to bedside
(This special issue belongs to the Section Methods and Technologies Development)
New Advances in the Treatment of Pediatric Solid Tumors
edited by and Oz Mordechai
submission deadline 20 Nov 2025 | 3 articles | Viewed by 7581 | Submission Open
Keywords: pediatric oncology; solid tumors; precision medicine; immunotherapy; artificial intelligence; innovative therapies
(This special issue belongs to the Section Pediatric Oncology)
Cancer Treatment: Present and Future of Radioligand Therapy submission deadline 20 Nov 2025 | 2 articles | Viewed by 6689 | Submission Open
Keywords: radioligand therapy; PRLT; FAPI; PSMA; CXCR4; GRPR; GLP-1R; RLT; novel radiopharmaceutical; cancer theranostics
(This special issue belongs to the Section Cancer Therapy)
Thyroid Cancer: New Advances from Diagnosis to Therapy: 2nd Edition
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 5623 | Submission Open
Keywords: thyroid scintigraphy; thyroid nodules; thyroid cancer; multikinase inhibitors; precision oncology; radioiodine
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)
edited by Nuria Romero-Laorden
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4974 | Submission Open
Keywords: immunotherapy; checkpoint inhibitors; biomarkers; immune biomarkers; PD-L1; TMB; solid tumors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Aberrant Cytokine Receptor Signaling in Hematological Cancers and Proliferative Disorders
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1178 | Submission Open
Keywords: cytokine receptor; signaling; leukemia; lymphoma; myeloproliferative neoplasm; hematology; oncology
(This special issue belongs to the Section Tumor Microenvironment)
Salivary and Tissue Biomarkers in Head and Neck Cancers: Diagnostic and Prognostic Role submission deadline 20 Nov 2025 | Viewed by 209 | Submission Open
Keywords: head and neck cancer; biomarker; early diagnosis and prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition submission deadline 21 Nov 2025 | 1 articles | Viewed by 2315 | Submission Open
Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness
(This special issue belongs to the Section Tumor Microenvironment)
Quality of Life in Patients with Brain Tumors
edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson
submission deadline 23 Nov 2025 | 1 articles | Viewed by 1734 | Submission Open
Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)
edited by
submission deadline 25 Nov 2025 | 4 articles | Viewed by 3899 | Submission Open
Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Trials of Sarcoma
edited by Patrick Schlegel
submission deadline 25 Nov 2025 | 1 articles | Viewed by 2006 | Submission Open
Keywords: cancer; sarcoma; clinical trial
Neurosurgical Advances in Brain Tumor Surgery
edited by Camilla Bonaudo, Alessandro Della Puppa and
submission deadline 28 Nov 2025 | 2 articles | Viewed by 3169 | Submission Open
Keywords: brain lesions/tumors; preoperative mapping; neuro-oncology; navigated TMS (n TMS); brain stimulation; optical imaging; cognitive mapping; awake surgery; functional mapping; functional preservation; intraoperative monitoring; neurophysiological monitoring
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Brachytherapy in the Treatment of Tumors
edited by
submission deadline 30 Nov 2025 | 12 articles | Viewed by 35686 | Submission Open
Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer
(This special issue belongs to the Section Cancer Therapy)
Novel Therapeutic Approaches for Cancer Treatment submission deadline 30 Nov 2025 | 13 articles | Viewed by 33736 | Submission Open
Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Radiomics and Imaging in Cancer Analysis submission deadline 30 Nov 2025 | 13 articles | Viewed by 26223 | Submission Open
Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology
(This special issue belongs to the Section Methods and Technologies Development)
Immunotherapy in the Management of Hematologic Malignancy
edited by Mohammad S. Hossain
submission deadline 30 Nov 2025 | 6 articles | Viewed by 22649 | Submission Open
Keywords: allo/auto HSCT; GvHD; immunotherapy; viral infection; hematologic malignancy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Recent Advances in Skin Cancers
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 19689 | Submission Open
Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system
(This special issue belongs to the Section Cancer Therapy)
New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor
edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo
submission deadline 30 Nov 2025 | 11 articles | Viewed by 14418 | Submission Open
Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology
(This special issue belongs to the Section Cancer Therapy)
Sarcoma: Clinical Trials and Management submission deadline 30 Nov 2025 | 6 articles | Viewed by 13882 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma
(This special issue belongs to the Section Clinical Research of Cancer)
Advancements in Surgical Approaches for Gynecological Cancers submission deadline 30 Nov 2025 | 9 articles | Viewed by 13000 | Submission Open
Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins
(This special issue belongs to the Section Cancer Therapy)
The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 11891 | Submission Open
Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1
(This special issue belongs to the Section Tumor Microenvironment)
Immune Landscape of Renal Cell Carcinoma
edited by and Yuexin Xu
submission deadline 30 Nov 2025 | 4 articles | Viewed by 11669 | Submission Open
Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions
edited by Yongwoo Dave Seo
submission deadline 30 Nov 2025 | 3 articles | Viewed by 10976 | Submission Open
Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design
(This special issue belongs to the Section Cancer Therapy)
Advances in Esophageal Cancer Treatment
edited by , , Pieter Van der Sluis and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 10501 | Submission Open
Keywords: gastric cancer; esophageal cancer; esophagectomy; chemotherapy; radiotherapy; immunotherapy; perioperative management; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Novel Advances in Surgery for Prostate Cancer
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 9536 | Submission Open
Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Research on Fluorescence-Guided Surgery in Cancer Treatment
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 9436 | Submission Open
Keywords: fluorescence-guided surgery; fluorescent agents; tumor fluorescence; tumor margin detection; residual tumor assessment; glioma surgery; fluorescein sodium; 5-aminolevulinic acid; confocal endomicroscopy; Raman spectroscopy
(This special issue belongs to the Section Cancer Therapy)
Cell Therapy in Solid Cancers: Current and Future Landscape
edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin
submission deadline 30 Nov 2025 | 2 articles | Viewed by 8824 | Submission Open
Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell
(This special issue belongs to the Section Cancer Therapy)
Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging
edited by Andra Valentina Krauze
submission deadline 30 Nov 2025 | 4 articles | Viewed by 7801 | Submission Open
Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations
(This special issue belongs to the Section Methods and Technologies Development)
Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)
edited by Jianguo Tao, Jeffrey W. Craig and Michael E. Williams
submission deadline 30 Nov 2025 | 3 articles | Viewed by 7254 | Submission Open
Keywords: B-cell malignancy; drug resistance; novel therapy; TME; chemoimmunotherapy; targeted agents; immunotherapeutic approaches
(This special issue belongs to the Section Cancer Therapy)
Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 7039 | Submission Open
Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome
(This special issue belongs to the Section Cancer Therapy)
New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice
edited by Xiaotong Song
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5251 | Submission Open
Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Surgical Treatment of Abdominal Tumors
edited by and Ioannis Baloyiannis
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4837 | Submission Open
Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal
(This special issue belongs to the Section Clinical Research of Cancer)
Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis (2nd Edition)
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 4610 | Submission Open
Keywords: receptor; tyrosine kinase; growth factor; signal transduction; development regeneration tumorigenesis
(This special issue belongs to the Section Molecular Cancer Biology)
Novel Computational Approaches for Molecular Target Discovery in Colorectal Cancer submission deadline 30 Nov 2025 | 1 articles | Viewed by 4382 | Submission Open
Keywords: colorectal cancer; genetics; bioinformatics; therapeutic targets; cancer evolution; personalized medicine; patient stratification; technological advancements; precision oncology; big data; computational approach
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Surgical Treatment of Spinal Tumors
edited by Daniel Lubelski
submission deadline 30 Nov 2025 | 4 articles | Viewed by 3793 | Submission Open
Keywords: spinal tumors; spinal metastases; minimally invasive spine surgery; radiosurgery; histology-specific treatment; prognostic modeling; machine learning; deep learning; spinal reconstruction; quality of life
(This special issue belongs to the Section Cancer Therapy)
Tissue-Agnostic Drug Development in Cancer (2nd Edition)
edited by Shivaani Kummar and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3675 | Submission Open
Keywords: tissue-agnostic drug development; pembrolizumab; microsatellite instability-high (MSI-H); tumor mutational burden-high (TMB-H); dostarlimab-gxly; larotrectinib; entrectinib; neurotrophic tyrosine kinase (NTRK)-fusion-positive solid tumors; dabrafenib and trametinib; selpercatinib; rearranged during transfection (RET) gene fusion; precision medicine
(This special issue belongs to the Section Cancer Drug Development)
Molecular Pathways in Cancers (2nd Edition) submission deadline 30 Nov 2025 | 2 articles | Viewed by 3492 | Submission Open
Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis
(This special issue belongs to the Section Molecular Cancer Biology)
Image Analysis and Machine Learning in Cancers: 2nd Edition submission deadline 30 Nov 2025 | 2 articles | Viewed by 3031 | Submission Open
Keywords: cancer detection and diagnosis system; machine learning; deep learning; medical imaging analysis; few-shot deep learning; attention segmentation; feature extraction; probabilistic models; explainability; image fusion; generative adversarial network
(This special issue belongs to the Section Methods and Technologies Development)
Calcium Signaling in Cancer Cell Progression
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2726 | Submission Open
Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Tumor Microenvironment in Primary Liver Cancer 2nd edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 2570 | Submission Open
Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome
(This special issue belongs to the Section Tumor Microenvironment)
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