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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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State of the Art and Advances in Kaposi Sarcoma
edited by
submission deadline 23 Sep 2025 | Viewed by 307
Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Rare Breast Tumors submission deadline 25 Sep 2025 | 8 articles | Viewed by 15322 | Submission Open
Keywords: rare breast tumors; rare histology; breast cancer; phylloides tumor; male breast cancer; CUP syndrome; breast implant-associated anaplastic large cell lymphoma; diabetic mastopathy; metaplastic breast cancer; apocrine breast cancer; inflammatory breast cancer; medullary breast cancer; mucinous breast cancer; adenoid cystic carcinoma of the breast; lymphoma of the breast; basal type breast cancer; angiosarcoma of the breast breast neuroendocrine tumors; brain metastases; PET imaging agents (FES; FFNP; and FDHT); microinvasive breast cancer; supraclavicular and contralateral axillary lymph node involvement; ectopic breast tissue; pregnancy-associated breast cancer
(This special issue belongs to the Section Cancer Therapy)
Genomics and Transcriptomics in Sarcoma
edited by George Jour and Jose G. Mantilla
submission deadline 25 Sep 2025 | 2 articles | Viewed by 1727 | Submission Open
Keywords: transcriptomics; single-cell RNA sequencing; machine learning; sarcoma
(This special issue belongs to the Section Molecular Cancer Biology)
Metastatic Progression of Human Melanoma: 2nd Edition submission deadline 25 Sep 2025 | 1 articles | Viewed by 1364 | Submission Open
Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies
(This special issue belongs to the Section Cancer Pathophysiology)
Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies submission deadline 30 Sep 2025 | 11 articles | Viewed by 34050 | Submission Open
Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma
(This special issue belongs to the Section Molecular Cancer Biology)
State of the Art and New Approaches to Spinal Cord Tumors
edited by Cédric Y. Barrey and Gabriele Capo
submission deadline 30 Sep 2025 | 8 articles | Viewed by 29164 | Submission Open
Keywords: neurosurgery; spinal cord tumors; ependymoma; microsurgery; neuromonitoring; neuroradiology; neurorehabilitation; neurohistology; neuro-oncology; intramedullary tumors
(This special issue belongs to the Section Methods and Technologies Development)
Gynecologic Cancer: Risk Factors, Interception and Prevention
edited by Brandy Heckman-Stoddard and Goli Samimi
submission deadline 30 Sep 2025 | 9 articles | Viewed by 20772 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; HPV; cancer prevention; gynecologic cancer risk reduction; gynecologic cancer interception; gynecologic cancer clinical trials
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Novel Approaches and Advances in Interventional Oncology
edited by and
submission deadline 30 Sep 2025 | 12 articles | Viewed by 19626 | Submission Open
Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Patient-Centered Outcomes of Colorectal Cancer Surgery
edited by Ira L. Leeds and Zhaomin Xu
submission deadline 30 Sep 2025 | 7 articles | Viewed by 14991 | Submission Open
Keywords: colorectal cancer; quality of life; postoperative outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Volume II)
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 13337 | Submission Open
Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Robot-Assisted Radical Prostatectomy for Urologic Cancer: State of the Art
edited by Jakub Dobruch
submission deadline 30 Sep 2025 | 7 articles | Viewed by 10923 | Submission Open
Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment
(This special issue belongs to the Section Methods and Technologies Development)
Monoclonal Antibodies in Lymphoma
edited by Donato Mannina
submission deadline 30 Sep 2025 | 3 articles | Viewed by 8571 | Submission Open
Keywords: monoclonal antibodies; immunotherapy; drug immunoconiugates; bispecific antibodies; checkpoints inhibitors; NHL; HL; CLL
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Urogenital Neoplasms Pathology
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 7408 | Submission Open
Keywords: urethroscopy; bladder cancer; prostate cancer; renal cancer; robotic surgery; laparoscopy; prostate biopsy
(This special issue belongs to the Section Cancer Pathophysiology)
The Application of Laparo-Endoscopic and Robotic Surgery in Cancer Treatments and Research
edited by Yutaro Kato
submission deadline 30 Sep 2025 | 3 articles | Viewed by 6122 | Submission Open
Keywords: cancer; minimally invasive surgery; laparoscopic surgery; endoscopic surgery; robotic surgery; telesurgery; periop-erative outcomes; oncologic outcomes; clinicopathology; molecular biology
(This special issue belongs to the Section Cancer Therapy)
Development, Validation and Application of Advanced Biomarkers in Cerebral Tumours
edited by Alan Jackson
submission deadline 30 Sep 2025 | 3 articles | Viewed by 5567 | Submission Open
(This special issue belongs to the Section Cancer Biomarkers)
Surgical Oncology for Hepato-Pancreato-Biliary Cancer
edited by Zaed Z. R. Hamady
submission deadline 30 Sep 2025 | 5 articles | Viewed by 5066 | Submission Open
Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach
(This special issue belongs to the Section Clinical Research of Cancer)
Adjuvant Therapy for Pancreatic Cancer
edited by Sonam Kumari
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4345 | Submission Open
Keywords: chemotherapy; pancreatic resections; overall survival; gemcitabine; pancreatic ductal adenocarcinoma
(This special issue belongs to the Section Cancer Therapy)
The Development and Application of Imaging Biomarkers in Cancer
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4239 | Submission Open
Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Cancer Risk Factors and Prognosis in Transplant Patients
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3272 | Submission Open
Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Merkel Cell Carcinoma: From Molecular Mechanisms to Clinical Therapy—a Selection of Papers from the 8th Nordic/1st European MCC Meeting
edited by , , John Paoli and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3023 | Submission Open
Keywords: merkel cell carcinoma; molecular biology; virology; immunology; biomarkers; epidemiology; primary treatment (surgery; radiation therapy); immunotherapy; targeted therapy; clinical trials
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplantation (HCT)
edited by Monzr M. Al-Malki
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1640 | Submission Open
Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; risk factors
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Systemic Therapy and Radiotherapy for the Treatment of Lung Cancer
edited by Gaurav Marwaha
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1580 | Submission Open
Keywords: chemoradiation; targeted therapy; immunotherapy; oligometastases; SBRT; biomarkers; NSCLC; small-cell lung cancer; PCI
(This special issue belongs to the Section Cancer Therapy)
Multiple Myeloma—Biology, Diagnosis, Treatment and Prognosis (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1494 | Submission Open
Keywords: multiple myeloma; bone marrow microenvironment; minimal residual disease; mass spectrometry; flow cytometry; CAR-T; bispecific agents; genomic alterations
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Integrated Management of Cancer (2nd Edition) submission deadline 30 Sep 2025 | 1 articles | Viewed by 1416 | Submission Open
Keywords: complementary medicine; epigenetics; diet; nutraceuticals; lifestyle; hemotherapy; radiotherapy; biological therapies; immunotherapy; nanotechnology; stem cells; repurposed drugs; combination treatments
(This special issue belongs to the Section Cancer Therapy)
Advanced Research on Radioresistant Tumors
edited by Mansoor M. Ahmed and Kamila Rawojć
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1313 | Submission Open
Keywords: radioresistant tumors; radiotherapy innovations; proton and heavy ion therapy; immunotherapy and radiotherapy combinations; genetic biomarkers; tumor hypoxia; combination treatment strategies; molecular oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in Chronic Lymphocytic Leukemia Microenvironment: The Disruption of the Supportive Leukemic/Accessory Cells Interactions to Improve Therapy Response, 2nd Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 1148 | Submission Open
Keywords: chronic lymphocytic leukemia; tumor microenvironment; cytokines targeted therapy; combination therapy; 2D/3D models of CLL– tumor microenviroment
(This special issue belongs to the Section Tumor Microenvironment)
Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer
edited by Daniel Martin
submission deadline 30 Sep 2025 | 1 articles | Viewed by 830 | Submission Open
Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy
(This special issue belongs to the Section Cancer Therapy)
The Role of Actin Binding Proteins in Cancer Progression
edited by Partha Roy
submission deadline 30 Sep 2025 | 1 articles | Viewed by 713 | Submission Open
Keywords: actin binding proteins; cancer biology; cell migration; angiogenesis; signaling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Antibody–Drug Conjugates (ADCs) in Cancers
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 642 | Submission Open
Keywords: antibody– drug conjugates (ADCs); therapeutic efficacy; drug delivery; structural features; disposition; linker design; payload optimization
(This special issue belongs to the Section Cancer Drug Development)
EGFR Signaling in Cancer (2nd Edition) submission deadline 30 Sep 2025 | Viewed by 599 | Submission Open
Keywords: epidermal growth factor receptor (EGFR); tumor microenvironment; drug resistance; clinical trial; cell signaling
(This special issue belongs to the Section Molecular Cancer Biology)
Advancements and Treatment Strategies for Central Nervous System Malignancies and Cancer Stem Cells
edited by Mingli Liu
submission deadline 30 Sep 2025 | Viewed by 340 | Submission Open
Keywords: central nervous system; signaling pathways; cancer stem cells; biomarker; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular Genomics in Brain Tumors submission deadline 30 Sep 2025 | Viewed by 335 | Submission Open
Keywords: glioma; signaling pathways; metabolism; microbiota– gut– brain axis; biomarkers; therapeutics; immunotherapy
(This special issue belongs to the Section Cancer Pathophysiology)
Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)
edited by Hiromichi Ito
submission deadline 30 Sep 2025 | Viewed by 305 | Submission Open
Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging
(This special issue belongs to the Section Cancer Therapy)
Translational Medicine in Gastroenteropancreatic Neuroendocrine Neoplasias
edited by
submission deadline 30 Sep 2025 | Viewed by 265 | Submission Open
Keywords: translational medicine; multiomics; improved diagnostics and therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Radiation Therapy in Lung Cancer: From a Technical Revolution to a Combination with New Systemic Approaches (2nd Edition)
edited by
submission deadline 30 Sep 2025 | Viewed by 261 | Submission Open
Keywords: NSCLC; SCLC; radiation therapy; SBRT; adjuvant RT; immunotherapy; concomitant treatments; toxicities
(This special issue belongs to the Section Cancer Therapy)
Clinical Trials for Diffuse Large B-Cell Lymphomas (DLBCL)
edited by
submission deadline 30 Sep 2025 | Viewed by 257 | Submission Open
Keywords: DLBCL; immunotherapy; drug combinations; elderly patients; ctDNA; biomarkers; radiotherapy; clinical trial management; artificial intelligence
(This special issue belongs to the Section Clinical Research of Cancer)
Chronic Lymphocytic Leukemia: From Genetics and Epigenetics to Therapy submission deadline 30 Sep 2025 | Viewed by 251 | Submission Open
Keywords: chronic lymphocytic leukemia; gene mutations; p53; immunoglobulin mutational status; epigenetics; methylation; MBL; drug resistance; drug treatments; Notch signaling; anti-apoptotic genes; Bcl-2; BTK; microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
Artificial Intelligence Supporting Global Cancer Statistics: Incidence and Mortality
edited by Margherita Ferrante and
submission deadline 30 Sep 2025 | Viewed by 248 | Submission Open
Keywords: artificial intelligence; big data; cancer statistics; oncological prevention; incidence; mortality
(This special issue belongs to the Section Methods and Technologies Development)
Pheochromocytoma, Paraganglioma and Neuroblastoma: Focus on Genetics—the Never-Ending Story
edited by María Currás-Freixes
submission deadline 30 Sep 2025 | Viewed by 228 | Submission Open
Keywords: hypoxia; treatment; surveillance; metastasis; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Treatment of Hepatopancreatobiliary Cancers: Open Question, Challenge, and Future Directions (2nd Edition) submission deadline 30 Sep 2025 | Viewed by 189 | Submission Open
Keywords: carcinoma; hepatocellular; liver neoplasms; transplant oncology; neoadjuvant and adjuvant therapy; artificial intelligence; cholangiocarcinoma; colorectal and non-colorectal liver metastasis; pancreatic neoplasms
(This special issue belongs to the Section Cancer Therapy)
Innovative Strategies and Techniques in Diagnosing, Treating and Surveying Soft Tissue Sarcomas
edited by H. Thomas Temple
submission deadline 30 Sep 2025 | Viewed by 178 | Submission Open
Keywords: sarcoma; soft tissue; pediatric; adult; biopsy; radiography; pathology; radiotherapy; surgery; molecular
(This special issue belongs to the Section Cancer Therapy)
Radiobiological Modelling in the New Era of Precision Radiation Oncology
edited by
submission deadline 1 Oct 2025 | 4 articles | Viewed by 9127 | Submission Open
Keywords: radiobiological modelling; precision radiation oncology; radiation therapy; cancers
(This special issue belongs to the Section Cancer Therapy)
The Role of Chromosomal Instability in Cancer: 2nd Edition
edited by
submission deadline 1 Oct 2025 | 3 articles | Viewed by 3779 | Submission Open
Keywords: aneuploidy; cancer evolution; chromothripsis; chromosomal translocation; genome chaos; genome instability; heterogeneity; karyotype coding; polyploid giant cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
Updates on Liver Cancer Management
edited by
submission deadline 1 Oct 2025 | 1 articles | Viewed by 1693 | Submission Open
Keywords: laparoscopic liver resection; minimally invasive liver resection; deteriorated liver function; anatomical resection; preoperative simulation; intraoperative navigation; liver metastasis; hepatocellular carcinoma biliary tract cancers; robot-assisted liver resection
(This special issue belongs to the Section Cancer Therapy)
The Genomic Landscape of Gynecological Cancers
edited by
submission deadline 1 Oct 2025 | Viewed by 183 | Submission Open
Keywords: gynecological cancers; tumor genomics; molecular profiling; precision oncology; targeted therapy; genetic alterations; multi-omics; tumor heterogeneity; biomarker discovery; translational research
(This special issue belongs to the Section Molecular Cancer Biology)
Breast Cancer: Tailored Rehabilitation Strategies to Address the Challenge of Survivorship Issues submission deadline 3 Oct 2025 | 5 articles | Viewed by 26611 | Submission Open
Keywords: breast cancer; rehabilitation; biomarkers; survivorship; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Immunometabolic Disorders and Early-Onset Gastrointestinal Cancer: Etiology, Incidence, Survival and Disparities
edited by Yunxia Lu
submission deadline 3 Oct 2025 | Viewed by 147 | Submission Open
Keywords: immunometabolic disorders; early-onset gastrointestinal cancer; cancer etiology; cancer incidence; cancer screening; cancer disparities; cancer survival; type 2 diabetes; diet and nutrition; obesity; autoimmune diseases; metabolic syndrome
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Research on Soft Tissue Sarcomas
edited by
submission deadline 6 Oct 2025 | Viewed by 264 | Submission Open
Keywords: soft tissue sarcoma; chondrosarcoma; Ewing sarcoma; osteosarcoma; precision medicine; emphasizing detection; treatment; surgery; radiologic imaging
(This special issue belongs to the Section Cancer Therapy)
Digital Health Technologies in Oncology submission deadline 10 Oct 2025 | 8 articles | Viewed by 13799 | Submission Open
Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Near-Infrared Photoimmunotherapy for Cancer Treatment: 2nd Edition
edited by
submission deadline 10 Oct 2025 | Viewed by 232 | Submission Open
Keywords: NIR-PIT; phototherapy; monoclonal antibody; imaging biomarker; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
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