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Cancers
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Advances in Esophagogastric Cancer
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Advances in Esophagogastric Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 7095

Special Issue Editors

Dr. B.P.L. (Bas) Wijnhoven

E-Mail Website
Guest Editor
Department of Surgery, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
Interests: esophageal cancer
Dr. Richard Skipworth

E-Mail Website
Guest Editor
Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK
Interests: cancer cachexia; muscle wasting; esophagogastric cancer; surgery; clinical trials
Special Issues, Collections and Topics in MDPI journals
Dr. Pieter Van der Sluis

E-Mail Website
Guest Editor
Department of Surgery, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
Interests: esophageal cancer
Dr. Tania Triantafyllou

E-Mail
Guest Editor
UGI Surgical Fellow, Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
Interests: esophageal cancer

Special Issue Information

Dear Colleagues,

We are launching a Special Issue of Cancers entitled “Advances in Esophageal Cancer Treatment”. Our aim is to present an overview of the current debates in the treatment of esophageal cancer and to investigate the future impact of the newly introduced advances in the field.

This Special Issue will focus on the development of the robot-assisted approach and diagnostic tools with the implementation of deep learning, radiomics and pathomics. At the same time, our goal is to enlighten the role of immunotherapy in the curative and palliative treatment of esophageal cancer, the current and future investigations on the genetics of the disease, organ-sparing treatments, the therapeutic approach to oligometastatic disease, the comparison between the proton versus photon beam radiation, and the advantages and limitations of follow-up protocols after curative treatment. The indicators for quality of care in esophageal malignancy, along with the evaluation of the existing databases from high-volume centers worldwide, stand among this Special Issue’s focuses.

You are highly welcome to submit an original article/review/meta-analysis to this Special Issue.

Dr. B.P.L. (Bas) Wijnhoven
Dr. Richard Skipworth
Dr. Pieter Van der Sluis
Dr. Tania Triantafyllou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastric cancer
  • esophageal cancer
  • esophagectomy
  • chemotherapy
  • radiotherapy
  • immunotherapy
  • perioperative management
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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14 pages, 4868 KiB  
Article
Gut Microbiome Changes After Neoadjuvant Chemotherapy and Surgery in Patients with Gastric Cancer
by Kristina Žukauskaitė, Bernardas Baušys, Angela Horvath, Rasa Sabaliauskaitė, Agnė Šeštokaitė, Agata Mlynska, Sonata Jarmalaitė, Vanessa Stadlbauer, Rimantas Baušys and Augustinas Baušys
Cancers 2024, 16(23), 4074; https://doi.org/10.3390/cancers16234074 - 5 Dec 2024
Viewed by 1366
Abstract
Background/Objectives: Neoadjuvant chemotherapy (NAC) followed by radical gastrectomy is the current standard approach for locally advanced gastric cancer (GC) in the West. Both NAC and gastrectomy can significantly influence the gut microbiome, potentially leading to clinically significant changes. However, no longitudinal studies to [...] Read more.
Background/Objectives: Neoadjuvant chemotherapy (NAC) followed by radical gastrectomy is the current standard approach for locally advanced gastric cancer (GC) in the West. Both NAC and gastrectomy can significantly influence the gut microbiome, potentially leading to clinically significant changes. However, no longitudinal studies to date support this hypothesis. This study investigates gut microbiome changes throughout GC treatment, including NAC and gastrectomy. Methods: This longitudinal observational study included GC patients undergoing NAC followed by gastrectomy. Fecal microbiome composition, intestinal inflammation (fecal calprotectin), and gut permeability (LBP, sCD14) markers were investigated at baseline, after NAC, and after gastrectomy. Results: A total of 38 patients were included in the study. The results showed that NAC did not affect the gut microbiome composition at the phylum level. In contrast, radical gastrectomy led to an increased abundance of Bacteroidetes and Proteobacteria and a decreased abundance of Firmicutes and Actinobacteria. Furthermore, NAC alone did not impact alpha or beta diversity, while a combination of NAC and gastrectomy significantly influenced both. After gastrectomy, the gut microbiome composition analysis also revealed enrichment of oralization-associated bacterial species such as Escherichia-Shigella, Streptococcus equinus, uncultured Streptococcus species, and species from the Enterobacteriaceae family. Intestinal inflammation and gut permeability markers did not significantly change throughout the treatment. Conclusions: The radical treatment of advanced GC with NAC and radical surgery has long-term effects on the gut microbiome, characterized by gut microbiome oralization. These sustained alterations primarily stem from the radical gastrectomy rather than the NAC. Since previous studies have linked oralization-associated dysbiosis to various gastrointestinal symptoms, this study highlights the gut microbiome as a potential therapeutic target to enhance the quality of life in long-term survivors following gastrectomy. Full article
(This article belongs to the Special Issue Advances in Esophagogastric Cancer)
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Review

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16 pages, 293 KiB  
Review
Emerging Trends in the Management of Gastric Malignancy with Peritoneal Dissemination: Same Disease, Heterogeneous Prognosis
by Evgenia Mela, Andreas Panagiotis Theodorou, Despina Kimpizi, Kyriaki Konstantinou, Nektarios Belimezakis, Dimitrios Schizas, Dimitrios Theodorou and Tania Triantafyllou
Cancers 2025, 17(1), 117; https://doi.org/10.3390/cancers17010117 - 2 Jan 2025
Viewed by 1078
Abstract
Gastric cancer is a significant global contributor to cancer-related mortality. Stage IV gastric cancer represents a significant percentage of patients in Western countries, with peritoneal dissemination being the most prevalent site. Peritoneal disease comprises two distinct entities, macroscopic (P1) and microscopic (P0CY1), which [...] Read more.
Gastric cancer is a significant global contributor to cancer-related mortality. Stage IV gastric cancer represents a significant percentage of patients in Western countries, with peritoneal dissemination being the most prevalent site. Peritoneal disease comprises two distinct entities, macroscopic (P1) and microscopic (P0CY1), which are associated with poor long-term survival rates. Although the present standard of treatment is palliative chemotherapy, a global controversy has arisen concerning specific patients with limited disease burden or conversion to negative lavage cytology following chemotherapy. Available approaches include systemic or intraperitoneal chemotherapy, upfront gastrectomy, and conversion surgery. This review consolidated the current evidence regarding multimodal management, indicating prolonged survival for this distinct subgroup of patients. Considering the complexity of peritoneal metastases, the potential of the multimodal approach unveils promising prospects for identifying the optimal treatment for this particular subset of stage IV patients and thus enhancing their survival outcomes. Full article
(This article belongs to the Special Issue Advances in Esophagogastric Cancer)
17 pages, 4681 KiB  
Review
The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers: Recent Trends and Future Perspectives
by Tejveer Singh, Deepika Sharma, Rishabh Sharma, Hardeep Singh Tuli, Shafiul Haque, Seema Ramniwas, Darin Mansor Mathkor and Vikas Yadav
Cancers 2024, 16(9), 1711; https://doi.org/10.3390/cancers16091711 - 27 Apr 2024
Cited by 4 | Viewed by 3850
Abstract
In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, [...] Read more.
In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, and Erk/MAPK pathway involved in cancer progression, showing its inhibitory effects on cell proliferation, survival, angiogenesis, metastasis, and migration. Kaempferol is processed in the liver and small intestine, but limited bioavailability has been a major concern in the clinical implications of kaempferol. Nano formulations have been proven to enhance kaempferol’s efficacy in cancer prevention. The synergy of nanotechnology and kaempferol has shown promising results in in vitro studies, highlighting the importance for more in vivo research and clinical trials to determine safety and efficacy. This review aims to focus on the role of kaempferol in various types of gastrointestinal cancer and how the combination of kaempferol with nanotechnology helps in improving therapeutic efficacy in cancer treatment. Full article
(This article belongs to the Special Issue Advances in Esophagogastric Cancer)
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