Aberrant Cytokine Receptor Signaling in Hematological Cancers and Proliferative Disorders

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 477

Special Issue Editor

Special Issue Information

Dear Colleagues,

Cytokine receptor signaling represents a paradigm for cell-to-cell communication, which plays a particularly pivotal role in facilitating the generation, maintenance, and function of blood and immune cells. Perhaps unsurprisingly, mutations and other aberrations impacting cytokine receptor signaling have been identified as the key causative agents for a diverse range of malignancies affecting the blood and immune cells, including proliferative disorders, leukemias and lymphomas.

This Special Issue will focus on these pathogenic aberrations in cytokine receptor signaling, highlighting the molecular underpinnings, their modes of action and their specific clinical presentations. It will detail relevant cellular and animal studies that model these disorders, as well as the pre-clinical and clinical studies that aim to investigate potential therapeutic strategies to ameliorate the effects of aberrant cytokine receptor signaling.

Prof. Dr. Alister C. Ward
Guest Editor

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Keywords

  • cytokine receptor
  • signaling
  • leukemia
  • lymphoma
  • myeloproliferative neoplasm
  • hematology
  • oncology

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Published Papers (1 paper)

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Review

16 pages, 830 KB  
Review
Colony-Stimulating Factor 3 Receptor Mutations and Variants in Hematological Malignancies
by Clifford Liongue, Tarindhi Ratnayake and Alister C. Ward
Cancers 2025, 17(20), 3378; https://doi.org/10.3390/cancers17203378 - 20 Oct 2025
Abstract
Colony-stimulating factor 3 (CSF3), additionally called granulocyte colony-stimulating factor (G-CSF), is the major cytokine regulating neutrophil production and also impacting their function. The actions of this cytokine are mediated through its unique receptor, the colony-stimulating factor 3 receptor (CSF3R). Several classes of pathogenic [...] Read more.
Colony-stimulating factor 3 (CSF3), additionally called granulocyte colony-stimulating factor (G-CSF), is the major cytokine regulating neutrophil production and also impacting their function. The actions of this cytokine are mediated through its unique receptor, the colony-stimulating factor 3 receptor (CSF3R). Several classes of pathogenic mutations in the CSF3R gene have been identified that have distinct biological properties and clinical impacts. This review provides an overview of CSF3R, the various pathogenic CSF3R mutations/variants and their biological effects. It also details the diseases to which they contribute, notably including chronic neutrophilic leukemia (CNL) and other myeloproliferative neoplasms (MPNs), myelodysplastic neoplasms (MDS), combined MDS/MPN disorders such as atypical chronic myeloid leukemia (aCML) and chronic myelomonocytic leukemia (CMML), as well as acute myeloid leukemia (AML) and lymphoid malignancies. Full article
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