Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 951
Special Issue Editors
Interests: B-cell malignancy; drug resistance; novel therapy
Special Issues, Collections and Topics in MDPI journals
Interests: lymphoid neoplasms
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of the Special Issue titled “Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed?” https://www.mdpi.com/journal/cancers/special_issues/6GH8RRC7FR.
Advances in our understanding of B-cell neoplasm biology, genetics, and immunology have allowed for the identification of new therapeutic targets and the emergence of bispecific antibodies, CAR T-cell therapies, and novel small-molecule inhibitors. However, outcomes for relapsed and/or refractory lymphoma, myeloma, and CLL with therapy resistance remain inadequate for most patients. Thus, an unmet need exists for the development of novel and effective therapeutic strategies based on lymphoma biology and resistance mechanisms. In this Special Issue, we will focus on the changing therapeutic landscape of B-cell malignancies, from chemoimmunotherapy to targeted agents and immunotherapeutic approaches, and the evolutionary trajectories of treatment resistance. We will provide perspectives and evidence-based rationale for novel combinatorial strategies to synergistically and reciprocally overcome treatment resistance, enhance clinical efficacy, and improve patient outcomes.
Prof. Dr. Jianguo Tao
Dr. Jeffrey W. Craig
Prof. Dr. Michael E. Williams
Guest Editors
Manuscript Submission Information
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Keywords
- B-cell malignancy
- drug resistance
- novel therapy
- TME
- chemoimmunotherapy
- targeted agents
- immunotherapeutic approaches
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