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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Diagnosis and Treatment of Prostate Cancer: From Biomarkers to Precision Surgery

edited by Stamatios N. Katsimperis and

Lazaros Tzelves

submission deadline 30 May 2026 | 1 articles | Viewed by 1049 | Submission Open

Keywords: prostate cancer; precision medicine; molecular biomarkers; risk stratification; robotic surgery; artificial intelligence; genomics; personalized treatment; imaging modalities; multidisciplinary approach

(This special issue belongs to the Section Cancer Therapy)

Minimally Invasive Surgery and Robotic Techniques in GI Cancer Treatment

edited by Luca Milone and Abid Qureshi

submission deadline 30 May 2026 | 1 articles | Viewed by 370 | Submission Open

Keywords: minimally invasive surgery; robotic surgery; gastrointestinal cancer; surgical oncology; laparoscopic surgery; advanced surgical technology; robotic-assisted procedures; AI in robotic surgery

(This special issue belongs to the Section Methods and Technologies Development)

Liquid Biopsy for Lung Cancer Treatment (2nd Edition)

edited by

Maria Palmieri

and Frullanti Elisa

submission deadline 30 May 2026 | Viewed by 319 | Submission Open

Keywords: cancer; lung cancer; new strategies; liquid biopsy; CTC; exosomes; Cf-NA; DdPCR; NGS

(This special issue belongs to the Section Cancer Biomarkers)

Genetics of Ovarian Cancer (2nd Edition)

edited by

Stergios Boussios

and

Sola Adeleke

submission deadline 30 May 2026 | Viewed by 218 | Submission Open

Keywords: epithelial ovarian cancer; genomics; epigenetics; translational research; biomarkers; DNA damage response; PARP inhibitors

(This special issue belongs to the Section Cancer Pathophysiology)

Updates on Depression Among Cancer Patients (2nd Edition)

edited by Wen-Yu Hu,

Yun-Chen Chang

and

Elsa Vitale

submission deadline 30 May 2026 | Viewed by 172 | Submission Open

Keywords: depression; psychotherapy; oncology nursing

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Blood Stem Cell and Hematological Malignancies (Second Edition)

edited by Dirk Loeffler

submission deadline 30 May 2026 | Viewed by 101 | Submission Open

Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation

(This special issue belongs to the Section Molecular Cancer Biology)

Integrating Radiomics and Radiotherapy in Cancer Care: Quantitative Imaging and Efficacy Assessment

edited by

Savino Cilla

submission deadline 30 May 2026 | Viewed by 78 | Submission Open

Keywords: radiomics; radiogenomics; radiation oncology; imaging biomarkers; predictive models; machine learning; precision radiotherapy; quantitative imaging

(This special issue belongs to the Section Methods and Technologies Development)

Revolutionizing Cancer Treatment: Advances in Radiation Therapy

edited by

Hans Christiansen

submission deadline 30 May 2026 | Viewed by 77 | Submission Open

Keywords: radiation therapy; radiooncology; radiobiology; radiosensitivity; high-precision radiotherapy; stereotactic radiotherapy; particle therapy; FLASH radiotherapy; image-guided radiotherapy (IGRT); radiochemotherapy; radioimmunotherapy; translational research; clinical outcome

(This special issue belongs to the Section Cancer Therapy)

Pathology of Renal Tumors

edited by

Guido Martignoni

and Anna Caliò

submission deadline 30 May 2026 | Viewed by 41 | Submission Open

Keywords: renal cell tumors; diagnosis; prognosis; metabolomics; genomics; molecular; immunohistochemistry; histopathology

(This special issue belongs to the Section Cancer Pathophysiology)

Mechanism of Action of Novel Anticancer Drugs in Cancer Treatment

edited by

Ruifang Liu

submission deadline 30 May 2026 | Viewed by 40 | Submission Open

Keywords: targeted therapy; immunotherapy; tumor-agostic approval; therapy resistence; mechaninsm of action; kinase inhibitor; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Drug Development)

Health Services Research in Cancer Care

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 31 May 2026 | 7 articles | Viewed by 16975 | Submission Open

Keywords: cancer care; cancer care outcomes; cancer care services; cancer costs; treatment; health systems; quality; survival; indicators; health technology assessments

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Developments in the Management of Gastrointestinal Malignancies (2nd Edition)

edited by Zachary J. Brown

submission deadline 31 May 2026 | 5 articles | Viewed by 12144 | Submission Open

Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic

(This special issue belongs to the Section Cancer Therapy)

Cancer Biomarkers—Detection and Evaluation of Response to Therapy

edited by

Giulio Francia

and

Jianying Zhang

submission deadline 31 May 2026 | 5 articles | Viewed by 9445 | Submission Open

Keywords: biomarkers; cancer detection; biomarkers of response to antineoplastic drugs; biomarkers of resistance to chemotherapy; biomarkers for targeted therapies

(This special issue belongs to the Section Cancer Biomarkers)

Gut Microbiome, Diet and Cancer Risk

edited by

Byeongsang Oh

submission deadline 31 May 2026 | 4 articles | Viewed by 8425 | Submission Open

Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches

edited by

Md Ataur Rahman

submission deadline 31 May 2026 | 1 articles | Viewed by 8064 | Submission Open

Keywords: glioblastoma; angiogenesis; reactive oxygen species (ROS); hypoxia-inducible factors (HIFs); radiotherapy (RT); bioactive natural compounds; tumor microenvironment (TME); cancer immunotherapy; combination therapy; autophagy; apoptosis; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Cancer Metastasis)

Advances in Proton Therapy for Head and Neck Cancer: Techniques, Outcomes and Planning Variations

edited by Jun Zhou

submission deadline 31 May 2026 | 3 articles | Viewed by 7771 | Submission Open

Keywords: proton head and neck cancer therapy; protons vs. photons for head and neck cancer treatment; adaptive proton therapy; robustness in proton head and neck cancer therapy; online vs. offline adaptation in proton head and neck cancer therapy

(This special issue belongs to the Section Cancer Therapy)

Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery

edited by Shengyang Peter Wu

submission deadline 31 May 2026 | 2 articles | Viewed by 7647 | Submission Open

Keywords: biomarker-guided personalized breast treatment; targeted axillary dissection; neoadjuvant therapy; local therapy; radiotherapy reduction; ultrahypofractionated partial breast irradiation

(This special issue belongs to the Section Cancer Therapy)

Advances in Treatment of Uveal Melanoma

edited by

Bożena Romanowska-Dixon

and

Michał S. Nowak

submission deadline 31 May 2026 | 2 articles | Viewed by 6380 | Submission Open

Keywords: uveal melanoma; distant metastases; treatment modalities

(This special issue belongs to the Section Cancer Therapy)

Updates on Thyroid Cancer

edited by

Kwangsoon Kim

and

Ja Seong Bae

submission deadline 31 May 2026 | 4 articles | Viewed by 6266 | Submission Open

Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer and Inflammation

edited by Takuji Hayashi

submission deadline 31 May 2026 | 2 articles | Viewed by 4129 | Submission Open

Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Pathways in Cancers (2nd Edition)

edited by

Ion Cristóbal

and

Marta Rodríguez Moreno

submission deadline 31 May 2026 | 2 articles | Viewed by 4001 | Submission Open

Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

MicroRNA in Cancer: From Molecular Mechanisms to Therapeutic Applications

edited by Girish Shukla and

Sivakumar Vijayaraghavalu

submission deadline 31 May 2026 | 4 articles | Viewed by 3339 | Submission Open

Keywords: microRNA (miRNA) therapeutics; cancer biomarkers; oncogenic and tumor-suppressive miRNAs; miRNA delivery systems; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

The Role of Circulating Tumor Cells in Colorectal Cancer

edited by

Chiara Nicolazzo

submission deadline 31 May 2026 | 1 articles | Viewed by 3236 | Submission Open

Keywords: circulating tumor cells (CTC); colorectal cancer (CRC); liquid biopsy; biomarkers; tumor progression; personalized medicine; molecular profiling; metastasis; diagnostic techniques; prognostic evaluation

(This special issue belongs to the Section Cancer Biomarkers)

Focus on Focal Therapy for Prostate Cancer

edited by Abhinav Sidana and Samuel Tremblay

submission deadline 31 May 2026 | 2 articles | Viewed by 3072 | Submission Open

Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance

(This special issue belongs to the Section Cancer Therapy)

Advances in Targeted Therapies in Cancer (2nd Edition)

edited by

Bulent Ozpolat

submission deadline 31 May 2026 | 1 articles | Viewed by 2801 | Submission Open

Keywords: targeted therapy; cancer; antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Cell and Gene Therapy in Tumors: From Bench to Bedside

edited by Shuhang Wang

submission deadline 31 May 2026 | 1 articles | Viewed by 2453 | Submission Open

Keywords: cell therapy; gene therapy; genetically engineered cells; cancer treatment; clinical trials; pre-clinical study

(This special issue belongs to the Section Cancer Therapy)

Quality of Life in Patients with Brain Tumors

edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson

submission deadline 31 May 2026 | 1 articles | Viewed by 2052 | Submission Open

Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Therapeutic Optimization of Anti-Tumor Drugs Based on Pharmacokinetics

edited by Paula Fresco and Joaquim António Faria Monteiro

submission deadline 31 May 2026 | 1 articles | Viewed by 1974 | Submission Open

Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models

(This special issue belongs to the Section Cancer Drug Development)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 31 May 2026 | 1 articles | Viewed by 1752 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Primary Central Nervous System Lymphoma: A Challenging Disease

edited by

Roser Velasco

submission deadline 31 May 2026 | 2 articles | Viewed by 1691 | Submission Open

Keywords: primary central nervous system lymphoma (PCNSL); diffuse large B cell lymphoma (DLBCL); advanced imaging; novel therapies; prognostic markers

(This special issue belongs to the Section Clinical Research of Cancer)

Clinical and Translational Research of Urological Cancer

edited by

Mauro Ragonese

and

Luca Di Gianfrancesco

submission deadline 31 May 2026 | 2 articles | Viewed by 1557 | Submission Open

Keywords: urological cancer; bladder cancer; surgery; conservative treatment; immunotherapy; radical cystectomy; artifical intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Neoadjuvant Chemotherapy and Radiotherapy for Breast Cancer: Surgical Impact and Clinical Outcomes

edited by Amparo García-Tejedor

submission deadline 31 May 2026 | 1 articles | Viewed by 1443 | Submission Open

Keywords: neoadjuvant chemotherapy; radiotherapy; breast cancer; surgical outcomes; tumor downstaging; personalized therapy; breast-conserving surgery; mastectomy; clinical outcomes

(This special issue belongs to the Section Cancer Therapy)

Survivorship and Quality of Life in Endometrial Cancer

edited by George Koukourakis,

Antonios Anagnostopoulos

, Georgios Angelopoulos and Anthi Miliadou

submission deadline 31 May 2026 | 1 articles | Viewed by 1326 | Submission Open

Keywords: endometrial cancer; quality of life; survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Current Status and Prospects of Multimodal Treatment for Upper Gastrointestinal Cancer

edited by Koichi Okamoto

submission deadline 31 May 2026 | 1 articles | Viewed by 1239 | Submission Open

Keywords: upper gastrointestinal cancer; esophageal cancer; gastric cancer; esophagogastric junction cancer; chemotherapy; oncology; endoscopic resection; minimally invasive surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

The Impact of Minimally Invasive Surgery on Gynecologic Cancers

edited by

Gabriel Levin

submission deadline 31 May 2026 | 1 articles | Viewed by 1207 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy

(This special issue belongs to the Section Cancer Therapy)

Nano-Targeting of Cancer

edited by Thomas Ming Swi Chang OC MD CM PhD DSc FRCPC FRSC FCAHS

submission deadline 31 May 2026 | 1 articles | Viewed by 971 | Submission Open

Keywords: drug delivery; artificial intelligence; targeted delivery; nanorobotics; prodrug activation; intracellular action; liposome; PEGylation; nanoparticles; nanocapsules; nanoartificial cells

(This special issue belongs to the Section Cancer Therapy)

Decoding the Dynamic Matrix Complexity in Cancer

edited by

Nikos Karamanos

Zoi Piperigkou

and

Luisa Bracci

submission deadline 31 May 2026 | Viewed by 528 | Submission Open

Keywords: extracellular matrix; cancer pathobiology; 3D spheroids/organoids; modeling tumor microenvironment complexity; matrix-based bioscaffolds; matrix remodeling; cell surface matrix mediators and effectors; matrix degrading enzymes; proteoglycans/glycosaminoglycans; collagen; matrix (glyco)proteins; molecular targeting

(This special issue belongs to the Section Tumor Microenvironment)

Multimodality Management of Sarcomas (2nd Edition)

edited by

Eelco de Bree

submission deadline 31 May 2026 | 1 articles | Viewed by 447 | Submission Open

Keywords: sarcomas; multimodal; pathology; radiology; surgery; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment

edited by Ewa Robak and

Tadeusz Robak

submission deadline 31 May 2026 | Viewed by 431 | Submission Open

Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Urological Cancer: Innovative Therapies and Biomarkers

edited by Hiroshi Yaegashi

submission deadline 31 May 2026 | 1 articles | Viewed by 372 | Submission Open

Keywords: urological oncology; urothelial cancer; prostate cancer; renal cancer; biomarkers; immunotherapy

Emerging Nanotechnology and Advanced Materials for Cancer Therapy

edited by

Iraj Alipourfard

submission deadline 31 May 2026 | Viewed by 275 | Submission Open

Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition)

edited by

Shumei Song

and

Jaffer A. Ajani

submission deadline 31 May 2026 | Viewed by 272 | Submission Open

Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

PET/CT in Radiation Oncology

edited by Gurdip Azad and

Gary Cook

submission deadline 31 May 2026 | Viewed by 235 | Submission Open

Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers

edited by

Andrea Belli

, Matteo Serenari and

Benedetto Ielpo

submission deadline 31 May 2026 | Viewed by 217 | Submission Open

Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy

(This special issue belongs to the Section Cancer Therapy)

Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease

edited by

Carlos M. Telleria

submission deadline 31 May 2026 | Viewed by 210 | Submission Open

Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy; quality of life; and prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Thermal Analysis and Proteomic Approaches for Biofluid Proteome Profiling in Cancer Diagnostics

edited by

Nichola C. Garbett

submission deadline 31 May 2026 | 1 articles | Viewed by 204 | Submission Open

Keywords: thermal analysis; proteomics; thermal liquid biopsy; differential scanning calorimetry; mass spectrometry; serum proteome; clinical diagnostics; cancer diagnostics; biospecimen

(This special issue belongs to the Section Methods and Technologies Development)

The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine

edited by Aftab Alam

submission deadline 31 May 2026 | Viewed by 178 | Submission Open

Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Mutagenesis and DNA Methylation in Aging

edited by Steven S. Smith

submission deadline 31 May 2026 | Viewed by 174 | Submission Open

Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns

(This special issue belongs to the Section Molecular Cancer Biology)

Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms

edited by

Kumar Ganesan

and

Kunka Mohanram Ramkumar

submission deadline 31 May 2026 | Viewed by 173 | Submission Open

Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Infectious Agents and Oesophageal Cancer (2nd Edition)

edited by

Shan Rajendra

and Mohammed Rabiei

submission deadline 31 May 2026 | Viewed by 162 | Submission Open

Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma

(This special issue belongs to the Section Infectious Agents and Cancer)

Displaying special issue 551-600 on page 12 of 25.

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