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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1421 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
Innovations in Endocrine Cancer—Technology, Techniques and Therapy (Second Edition)
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1375 | Submission Open
Keywords: endocrine cancer; thyroid cancer; parathyroid; adrenals; melanoma; pancreas; neoplasms; minimally invasive surgeries
(This special issue belongs to the Section Methods and Technologies Development)
Image-Guided Treatment of Liver Tumors
edited by and Niek Wijnen
submission deadline 30 Apr 2026 | 2 articles | Viewed by 1211 | Submission Open
Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology
(This special issue belongs to the Section Cancer Therapy)
Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology
edited by Evrim Erdemogľu
submission deadline 30 Apr 2026 | 1 articles | Viewed by 885 | Submission Open
Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery
(This special issue belongs to the Section Clinical Research of Cancer)
The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods
edited by Peter C. Angeletti
submission deadline 30 Apr 2026 | 1 articles | Viewed by 826 | Submission Open
Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Current Concept and Management of Pediatric ATRTs—2nd Edition
edited by and Alicia C. Lenzen
submission deadline 30 Apr 2026 | 2 articles | Viewed by 721 | Submission Open
Keywords: atypical teratoid rhabdoid tumors (ATRTs); CNS tumor; embryonal tumors
(This special issue belongs to the Section Pediatric Oncology)
The Biomarkers of Oral Cancer
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 561 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Advances in the Molecular Pathogenesis of T-Cell Lymphoma
edited by
submission deadline 30 Apr 2026 | Viewed by 459 | Submission Open
Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers
(This special issue belongs to the Section Cancer Pathophysiology)
Medical Treatment for Urological Cancers submission deadline 30 Apr 2026 | Viewed by 446 | Submission Open
Keywords: prostate cancer; urothelial cancer; renal cancer; antibody– drug conjugates; cytotoxic chemotherapy; immune checkpoint inhibitors
(This special issue belongs to the Section Cancer Therapy)
Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 427 | Submission Open
Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP  models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost 
(This special issue belongs to the Section Cancer Therapy)
PARP Inhibitors in Cancers: 2nd Edition submission deadline 30 Apr 2026 | 1 articles | Viewed by 383 | Submission Open
Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications
edited by
submission deadline 30 Apr 2026 | Viewed by 374 | Submission Open
Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application
(This special issue belongs to the Section Tumor Microenvironment)
Cancer Inhibitory Receptors and Related Cancer Immunotherapy
edited by Keqiang Chen, Feng Zhu and Xin Li
submission deadline 30 Apr 2026 | Viewed by 361 | Submission Open
Keywords: cancer inhibitory receptors; ligands for inhibitor receptors; immune checkpoint inhibitors; cancer cells; immune cells; non-immune cells; inhibitor receptor pathways; immune checkpoint blockade therapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeted Therapies for Pediatric Nervous System Tumors
edited by and Nicole Brossier
submission deadline 30 Apr 2026 | Viewed by 361 | Submission Open
Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma
(This special issue belongs to the Section Pediatric Oncology)
New Insights in Esophageal Cancer Diagnosis and Treatment
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 288 | Submission Open
Keywords: esophageal cancer; diagnosis; targeted screening; endoscopic treatment
(This special issue belongs to the Section Cancer Therapy)
Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment
edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna
submission deadline 30 Apr 2026 | Viewed by 283 | Submission Open
Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics
(This special issue belongs to the Section Methods and Technologies Development)
Precision Medicine in Hematological Malignancies: Current Insights and Future Directions
edited by Giuseppe Saglio and Mohamed Yassin
submission deadline 30 Apr 2026 | Viewed by 279 | Submission Open
Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling
(This special issue belongs to the Section Cancer Therapy)
Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy
edited by Heena Kumra and Makoto Noda
submission deadline 30 Apr 2026 | Viewed by 273 | Submission Open
Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Cancer Pathophysiology)
The Role of Artificial Intelligence in Thyroid, Thoracic and Gastrointestinal Tumors: Transforming the Landscape of Diagnosis and Treatment submission deadline 30 Apr 2026 | Viewed by 249 | Submission Open
Keywords: artificial intelligence; thyroid cancer; thoracic cancer; gastrointestinal cancer; diagnosis; medical imaging; treatment; surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers
edited by Patriciu Achimas-Cadariu and
submission deadline 30 Apr 2026 | Viewed by 229 | Submission Open
Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers
Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer submission deadline 30 Apr 2026 | Viewed by 192 | Submission Open
Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
The Changing Paradigms in the Management of Thyroid Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 182 | Submission Open
Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications submission deadline 30 Apr 2026 | Viewed by 180 | Submission Open
Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes
(This special issue belongs to the Section Cancer Therapy)
Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 179 | Submission Open
Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy
(This special issue belongs to the Section Cancer Metastasis)
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Apr 2026 | Viewed by 166 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes
edited by
submission deadline 30 Apr 2026 | Viewed by 148 | Submission Open
Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life
edited by , and Juan Carlos Hernández-Rodríguez
submission deadline 30 Apr 2026 | Viewed by 141 | Submission Open
Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers submission deadline 30 Apr 2026 | Viewed by 137 | Submission Open
Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up
(This special issue belongs to the Section Cancer Therapy)
Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy submission deadline 30 Apr 2026 | Viewed by 133 | Submission Open
Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft
(This special issue belongs to the Section Cancer Therapy)
Management of Orbital Tumors
edited by
submission deadline 30 Apr 2026 | Viewed by 131 | Submission Open
Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques
(This special issue belongs to the Section Clinical Research of Cancer)
Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours
edited by Crispin T. Hiley and Iain Phillips
submission deadline 30 Apr 2026 | Viewed by 126 | Submission Open
Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR
(This special issue belongs to the Section Cancer Therapy)
EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open
Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer
(This special issue belongs to the Section Cancer Therapy)
Non-Melanoma Skin Cancer: Promises and Challenges submission deadline 30 Apr 2026 | Viewed by 115 | Submission Open
Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique
(This special issue belongs to the Section Cancer Therapy)
Liquid Biopsies in Gynecologic Cancer
edited by , and Ludovica Pepe
submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open
Keywords: liquid biopsy; gynecologic cancer; circulating tumor DNA (ctDNA); ovarian cancer; endometrial cancer; cervical cancer; early detection; personalized medicine; cancer monitoring; non-invasive diagnostics
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research
edited by and Tamer Saad Kaoud
submission deadline 30 Apr 2026 | Viewed by 105 | Submission Open
Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research
(This special issue belongs to the Section Clinical Research of Cancer)
Research and Clinical Applications of Gynecologic Cancer Detection Technologies
edited by Porfyrios Korompelis
submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open
Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies
(This special issue belongs to the Section Methods and Technologies Development)
Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies
edited by Giuseppe Marulli
submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery
(This special issue belongs to the Section Cancer Therapy)
Clinical Research on the Relationship Between Diet and Cancer Development (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 100 | Submission Open
Keywords: diet; nutrition; complementary therapy; vitamins; minerals; micro-nutrients; survival; cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open
Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance
(This special issue belongs to the Section Cancer Therapy)
Tumor Model for the Development of Anti-Cancer Drugs
edited by
submission deadline 30 Apr 2026 | Viewed by 95 | Submission Open
Keywords: tumor models; preclinical cancer models; organoids and spheroids; patient-derived xenografts (PDX); syngeneic models; 3D bioprinting (tumors); tumor-on-chip; drug development; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Role of Myeloid Cells in the Regulation of Cancer Onset and Development
edited by Rita Campanelli
submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open
Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open
Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA
(This special issue belongs to the Section Infectious Agents and Cancer)
Surgical Treatment and Postoperative Outcomes of Gynecological Cancers
edited by Lauren S. Prescott
submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open
Keywords: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization; surgery; hysterectomy; ovarian cancer; endometrial cancer; cervical cancer
(This special issue belongs to the Section Cancer Therapy)
Adverse Effects During Cancer Treatment
edited by Yan Gong
submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open
Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Biliary Tract Cancer: Multidisciplinary Perspectives in Surgery, Endoscopic Management, and Epidemiology
edited by Hiroyuki Kato
submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; ampullary cancer; hepatobiliary surgery; ERCP; biliary drainage; epidemiology; immunotherapy; multidisciplinary treatment; translational research
Cutaneous T-Cell Lymphomas in Special Populations
edited by and Caroline Myers
submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open
Keywords: cutaneous T-cell lymphoma; adult T-cell leukemia/lymphoma; lymphoproliferative disorder; hematopoietic stem cell transplant; secondary malignancy; pediatric lymphoma; skin of color; health care disparities; translational research
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 May 2026 | 3 articles | Viewed by 9868 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Treatment Response Biomarkers in Hepatocellular Carcinoma: From Basic Science to Clinical Validation
edited by
submission deadline 1 May 2026 | 3 articles | Viewed by 6405 | Submission Open
Keywords: hepatocellular carcinoma; prognostic biomarkers; liver-directed therapy; immune checkpoint inhibitors; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Medical Imaging for Cancer Detection and Diagnosis
edited by Claudia R. Mello-Thoms and Mark Anastasio
submission deadline 1 May 2026 | 1 articles | Viewed by 5572 | Submission Open
Keywords: photon-counting CT applications and developments; radiomics; AI and ML applications; collaborative CAD/AI; computational pathology; multimodality imaging of cancer; especially in vivo; emerging cancer imaging modalities; cancer imaging; machine learning; artificial intelligence; medical imaging
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cell Adhesion in Human Cancer
edited by , Makoto Osanai and
submission deadline 1 May 2026 | 2 articles | Viewed by 5057 | Submission Open
Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells
(This special issue belongs to the Section Molecular Cancer Biology)
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