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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gene Editing and Delivery for Cancer Therapy (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 155 | Submission Open
Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science
(This special issue belongs to the Section Cancer Therapy)
Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 143 | Submission Open
Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET
(This special issue belongs to the Section Molecular Cancer Biology)
Mass Spectrometry and Cancers submission deadline 15 May 2026 | Viewed by 116 | Submission Open
Keywords: cancer; biomolecular; mass spectrometry
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Locoregional Therapies for Gastrointestinal Cancer Metastases submission deadline 15 May 2026 | Viewed by 90 | Submission Open
Keywords: gastrointestinal cancer metastases; locoregional therapies; interventional radiology; endoscopy; radiation therapy; invasive operations; cytoreductive surgery (CRS); intraperitoneal chemotherapy (IP); heated intraperitoneal chemotherapy (HIPEC); tumor debulking; stereotactic body radiation therapy (SBRT); selective internal radiation therapy (SIRT)
(This special issue belongs to the Section Methods and Technologies Development)
The Surgical Management of Colorectal Cancer
edited by Gyung-mo Son
submission deadline 20 May 2026 | 10 articles | Viewed by 25935 | Submission Open
Keywords: colorectal cancer; surgical management; minimally invasive surgery; laparoscopic surgery; robotic surgery; single port surgery; emergency surgery; image-guided surgery; enhanced recovery after surgery (ERAS); systemic metastasis in colorectal cancer (involving the liver; lung; peritoneum; etc.)
(This special issue belongs to the Section Cancer Therapy)
New Advances in the Treatment of Pediatric Solid Tumors
edited by and Oz Mordechai
submission deadline 20 May 2026 | 3 articles | Viewed by 8298 | Submission Open
Keywords: pediatric oncology; solid tumors; precision medicine; immunotherapy; artificial intelligence; innovative therapies
(This special issue belongs to the Section Pediatric Oncology)
Improving the Quality of Life in Patients with Gynecological Cancer
edited by Vasilios Pergialiotis
submission deadline 20 May 2026 | 1 articles | Viewed by 4713 | Submission Open
Keywords: gynecologic oncology; minimal invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition; cervical cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
From Bench to Bedside: Novel Molecular Targets and Therapeutic Strategies in AML
edited by Matteo Molica
submission deadline 20 May 2026 | 2 articles | Viewed by 1973 | Submission Open
Keywords: acute myeloid leukemia; targeted therapy; precision medicine; FLT3 inhibitors; IDH1/2 inhibitors; BCL2 inhibition; menin inhibitors; drug resistance; minimal residual disease; combination therapy
(This special issue belongs to the Section Cancer Therapy)
How to Properly Diagnose and Treat Immune-Related Adverse Events During Immunotherapy in Patients with Cancer: Discussion Between Specialists (2nd Edition) submission deadline 20 May 2026 | Viewed by 100 | Submission Open
Keywords: ICIs; immune-related adverse effects (irAEs); infectious complications; immune reconstitution; inflammatory syndrome (IRIS); microbiota; vaccines; molecular mimicry
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Endometrial Cancer Prevention, Early Diagnosis and Treatment
edited by
submission deadline 20 May 2026 | Viewed by 91 | Submission Open
Keywords: endometrial cancer; gynaecologic oncology; surgery; prevention; early diagnosis; advanced therapy; molecular classification; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Advances in T-Cell Redirecting Therapy in Plasma Cell Neoplasms
edited by Henry Chi Hang Fung and Asya Varshavsky
submission deadline 20 May 2026 | Viewed by 90 | Submission Open
Keywords: multiple myeloma; CAR-T; T-cell engager; novel targets; sequencing
(This special issue belongs to the Section Cancer Therapy)
Viral Oncogenes and Their Role in Cancer Pathogenesis
edited by and Yosef Sabo
submission deadline 21 May 2026 | 3 articles | Viewed by 7082 | Submission Open
Keywords: viral oncogenes; cancer pathogenesis; cellular regulation; tumorigenesis mechanisms; antiviral and anticancer strategies
(This special issue belongs to the Section Infectious Agents and Cancer)
Non-Melanoma Skin Cancer: A Growing Problem in the Elderly Population
edited by Jolanta Jaworek and Dariusz Kowalczyk
submission deadline 21 May 2026 | Viewed by 42 | Submission Open
Keywords: NMSC; pathomechanism of NMSC; NMSC and gut and/or skin microbiota; NMSC treatment; NMSC diagnosis
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Next-Generation Automation in Radiation Oncology: Innovations in Planning, Informatics, and Clinical Workflow
edited by and Jared Becksfort
submission deadline 22 May 2026 | Viewed by 36 | Submission Open
Keywords: radiation oncology; radiotherapy automation; autosegmentation; rapid automated treatment planning; zero-click quality assurance; fast clinical workflow; artificial intelligence; machine learning; clinical decision support; radiomics; image-guided radiotherapy; adaptive radiation therapy; human-in-the-loop automation; healthcare informatics
(This special issue belongs to the Section Methods and Technologies Development)
Inhibitors in Thyroid Carcinoma (2nd Edition) submission deadline 24 May 2026 | Viewed by 133 | Submission Open
Keywords: thyroid carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; sorafenib; lenvatinib
(This special issue belongs to the Section Tumor Microenvironment)
Study on Acute Myeloid Leukemia
edited by Olga K. Weinberg
submission deadline 25 May 2026 | 3 articles | Viewed by 6565 | Submission Open
Keywords: acute myeloid leukemia (AML); cancer treatment; genetic
(This special issue belongs to the Section Cancer Therapy)
Clinical Advances and State-of-the-Art Management in Genitourinary Cancers
edited by and Adnan Fazili
submission deadline 25 May 2026 | 2 articles | Viewed by 4893 | Submission Open
Keywords: genitourinary malignancies; tumor– immune microenvironment (TIME); tumor biology; genomic characterization; targeted drug therapy; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)
edited by
submission deadline 25 May 2026 | 4 articles | Viewed by 4462 | Submission Open
Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction
(This special issue belongs to the Section Molecular Cancer Biology)
Colorectal Cancer: Risk Factors and Underlying Mechanisms
edited by David Achaintre
submission deadline 25 May 2026 | 1 articles | Viewed by 606 | Submission Open
Keywords: colorectal cancer; diet; environmental factors; microbiome; inflammation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Digital Health Technologies in Oncology: 2nd Edition submission deadline 25 May 2026 | Viewed by 106 | Submission Open
Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics.
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Mechanisms of Breast Cancer Treatment-Related Side Effects and Precision Interventions
edited by
submission deadline 26 May 2026 | Viewed by 115 | Submission Open
Keywords: breast cancer; treatment-related side effects; biomarker; precision interventions
(This special issue belongs to the Section Cancer Therapy)
Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies
edited by Nithya Ratnavelu and Ioannis Biliatis
submission deadline 28 May 2026 | 4 articles | Viewed by 5643 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
New Approaches in Radiotherapy for Cancer
edited by Dandan Zheng, Alexander Podgorsak and Olga Maria Dona Lemus
submission deadline 30 May 2026 | 21 articles | Viewed by 80528 | Submission Open
Keywords: adaptive radiotherapy; FLASH; artificial intelligence; SFRT; particle therapy; proton therapy; SRS; SBRT; HDR; 3D printing; immuno-radiotherapy; radiogenmics
(This special issue belongs to the Section Cancer Therapy)
Advances in the Surgical Treatment of Spinal Tumors
edited by Daniel Lubelski
submission deadline 30 May 2026 | 4 articles | Viewed by 4373 | Submission Open
Keywords: spinal tumors; spinal metastases; minimally invasive spine surgery; radiosurgery; histology-specific treatment; prognostic modeling; machine learning; deep learning; spinal reconstruction; quality of life
(This special issue belongs to the Section Cancer Therapy)
AI-Driven Oncology: Advancing Cancer Detection, Diagnosis, and Personalized Treatment submission deadline 30 May 2026 | 4 articles | Viewed by 3904 | Submission Open
Keywords: cancer detection and diagnosis; AI in oncology; explainable AI (XAI); precision oncology; medical imaging; prognostic biomarkers; clinical decision support systems
(This special issue belongs to the Section Methods and Technologies Development)
Endoscopic Management of Pancreatic Neoplasms (2nd Edition)
edited by
submission deadline 30 May 2026 | 2 articles | Viewed by 3678 | Submission Open
Keywords: pancreatic cancer; pancreatic neoplasm; endoscopic retrograde cholangiopancreatography; endoscopic ultrasound; fine needle aspiration/biopsy; local treatment; biliary stent; biliary drainage; contrast enhancement
(This special issue belongs to the Section Methods and Technologies Development)
New and Future Focused Therapies for Thyroid Cancer
edited by , Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia
submission deadline 30 May 2026 | 1 articles | Viewed by 1990 | Submission Open
Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Skin Cancer Prevention: Strategies, Challenges and Future Directions
edited by Véronique del Marmol, Mariano Suppa, Ana-Maria Forsea and Alexander Stratigos
submission deadline 30 May 2026 | 3 articles | Viewed by 1724 | Submission Open
Keywords: skin cancer prevention; photoprotection; early detection; screening; epidemiology; public health; behavioral interventions; sun exposure; artificial intelligence; risk factors
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Current Advances in Management of Neuroendocrine Neoplasms
edited by Ashley Kieran Clift and
submission deadline 30 May 2026 | 1 articles | Viewed by 1636 | Submission Open
Keywords: neuroendocrine tumours; epidemiology; clinical prediction models; machine learning; personalised medicine; novel biomarkers; diagnostics; treatment; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Radiomics in Head and Neck Cancer Care (2nd Edition)
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1163 | Submission Open
Keywords: radiomics; personalized therapeutic approach; radiology; improving outcome; head and neck cancer; imaging biomarkers; artificial intelligence
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Diagnosis and Treatment of Prostate Cancer: From Biomarkers to Precision Surgery
edited by Stamatios N. Katsimperis and
submission deadline 30 May 2026 | 1 articles | Viewed by 677 | Submission Open
Keywords: prostate cancer; precision medicine; molecular biomarkers; risk stratification; robotic surgery; artificial intelligence; genomics; personalized treatment; imaging modalities; multidisciplinary approach
(This special issue belongs to the Section Cancer Therapy)
Liquid Biopsy for Lung Cancer Treatment (2nd Edition)
edited by and Frullanti Elisa
submission deadline 30 May 2026 | Viewed by 297 | Submission Open
Keywords: cancer; lung cancer; new strategies; liquid biopsy; CTC; exosomes; Cf-NA; DdPCR; NGS
(This special issue belongs to the Section Cancer Biomarkers)
Genetics of Ovarian Cancer (2nd Edition) submission deadline 30 May 2026 | Viewed by 180 | Submission Open
Keywords: epithelial ovarian cancer; genomics; epigenetics; translational research; biomarkers; DNA damage response; PARP inhibitors
(This special issue belongs to the Section Cancer Pathophysiology)
Updates on Depression Among Cancer Patients (2nd Edition)
edited by Wen-Yu Hu, and
submission deadline 30 May 2026 | Viewed by 159 | Submission Open
Keywords: depression; psychotherapy; oncology nursing
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Minimally Invasive Surgery and Robotic Techniques in GI Cancer Treatment
edited by Luca Milone and Abid Qureshi
submission deadline 30 May 2026 | Viewed by 151 | Submission Open
Keywords: minimally invasive surgery; robotic surgery; gastrointestinal cancer; surgical oncology; laparoscopic surgery; advanced surgical technology; robotic-assisted procedures; AI in robotic surgery
(This special issue belongs to the Section Methods and Technologies Development)
Blood Stem Cell and Hematological Malignancies (Second Edition)
edited by Dirk Loeffler
submission deadline 30 May 2026 | Viewed by 89 | Submission Open
Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation
(This special issue belongs to the Section Molecular Cancer Biology)
Integrating Radiomics and Radiotherapy in Cancer Care: Quantitative Imaging and Efficacy Assessment
edited by
submission deadline 30 May 2026 | Viewed by 33 | Submission Open
Keywords: radiomics; radiogenomics; radiation oncology; imaging biomarkers; predictive models; machine learning; precision radiotherapy; quantitative imaging
(This special issue belongs to the Section Methods and Technologies Development)
Revolutionizing Cancer Treatment: Advances in Radiation Therapy
edited by
submission deadline 30 May 2026 | Viewed by 30 | Submission Open
Keywords: radiation therapy; radiooncology; radiobiology; radiosensitivity; high-precision radiotherapy; stereotactic radiotherapy; particle therapy; FLASH radiotherapy; image-guided radiotherapy (IGRT); radiochemotherapy; radioimmunotherapy; translational research; clinical outcome
(This special issue belongs to the Section Cancer Therapy)
Mechanism of Action of Novel Anticancer Drugs in Cancer Treatment
edited by
submission deadline 30 May 2026 | Viewed by 13 | Submission Open
Keywords: targeted therapy; immunotherapy; tumor-agostic approval; therapy resistence; mechaninsm of action; kinase inhibitor; immune checkpoint inhibitor
(This special issue belongs to the Section Cancer Drug Development)
Pathology of Renal Tumors
edited by and Anna Caliò
submission deadline 30 May 2026 | Viewed by 2 | Submission Open
Keywords: renal cell tumors; diagnosis; prognosis; metabolomics; genomics; molecular; immunohistochemistry; histopathology
(This special issue belongs to the Section Cancer Pathophysiology)
Health Services Research in Cancer Care submission deadline 31 May 2026 | 7 articles | Viewed by 15987 | Submission Open
Keywords: cancer care; cancer care outcomes; cancer care services; cancer costs; treatment; health systems; quality; survival; indicators; health technology assessments
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Developments in the Management of Gastrointestinal Malignancies (2nd Edition)
edited by Zachary J. Brown
submission deadline 31 May 2026 | 4 articles | Viewed by 10052 | Submission Open
Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic
(This special issue belongs to the Section Cancer Therapy)
Cancer Biomarkers—Detection and Evaluation of Response to Therapy submission deadline 31 May 2026 | 5 articles | Viewed by 8921 | Submission Open
Keywords: biomarkers; cancer detection; biomarkers of response to antineoplastic drugs; biomarkers of resistance to chemotherapy; biomarkers for targeted therapies
(This special issue belongs to the Section Cancer Biomarkers)
Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 7414 | Submission Open
Keywords: glioblastoma; angiogenesis; reactive oxygen species (ROS); hypoxia-inducible factors (HIFs); radiotherapy (RT); bioactive natural compounds; tumor microenvironment (TME); cancer immunotherapy; combination therapy; autophagy; apoptosis; in silico and network pharmacology; bioinformatics
(This special issue belongs to the Section Cancer Metastasis)
Gut Microbiome, Diet and Cancer Risk
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 7343 | Submission Open
Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Proton Therapy for Head and Neck Cancer: Techniques, Outcomes and Planning Variations
edited by Jun Zhou
submission deadline 31 May 2026 | 3 articles | Viewed by 7193 | Submission Open
Keywords: proton head and neck cancer therapy; protons vs. photons for head and neck cancer treatment; adaptive proton therapy; robustness in proton head and neck cancer therapy; online vs. offline adaptation in proton head and neck cancer therapy
(This special issue belongs to the Section Cancer Therapy)
Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery
edited by Shengyang Peter Wu
submission deadline 31 May 2026 | 2 articles | Viewed by 7121 | Submission Open
Keywords: biomarker-guided personalized breast treatment; targeted axillary dissection; neoadjuvant therapy; local therapy; radiotherapy reduction; ultrahypofractionated partial breast irradiation
(This special issue belongs to the Section Cancer Therapy)
Advances in Treatment of Uveal Melanoma submission deadline 31 May 2026 | 2 articles | Viewed by 5619 | Submission Open
Keywords: uveal melanoma; distant metastases; treatment modalities
(This special issue belongs to the Section Cancer Therapy)
Updates on Thyroid Cancer
edited by and
submission deadline 31 May 2026 | 3 articles | Viewed by 5456 | Submission Open
Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes
(This special issue belongs to the Section Cancer Therapy)
Prostate Cancer and Inflammation
edited by Takuji Hayashi
submission deadline 31 May 2026 | 2 articles | Viewed by 3410 | Submission Open
Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
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