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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Primary Central Nervous System Lymphoma: A Challenging Disease

edited by

Roser Velasco

submission deadline 31 May 2026 | 2 articles | Viewed by 1451 | Submission Open

Keywords: primary central nervous system lymphoma (PCNSL); diffuse large B cell lymphoma (DLBCL); advanced imaging; novel therapies; prognostic markers

(This special issue belongs to the Section Clinical Research of Cancer)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 31 May 2026 | 1 articles | Viewed by 1277 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Clinical and Translational Research of Urological Cancer

edited by

Mauro Ragonese

and

Luca Di Gianfrancesco

submission deadline 31 May 2026 | 2 articles | Viewed by 1192 | Submission Open

Keywords: urological cancer; bladder cancer; surgery; conservative treatment; immunotherapy; radical cystectomy; artifical intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

Survivorship and Quality of Life in Endometrial Cancer

edited by George Koukourakis,

Antonios Anagnostopoulos

, Georgios Angelopoulos and Anthi Miliadou

submission deadline 31 May 2026 | 1 articles | Viewed by 1182 | Submission Open

Keywords: endometrial cancer; quality of life; survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Neoadjuvant Chemotherapy and Radiotherapy for Breast Cancer: Surgical Impact and Clinical Outcomes

edited by Amparo García-Tejedor

submission deadline 31 May 2026 | 1 articles | Viewed by 1117 | Submission Open

Keywords: neoadjuvant chemotherapy; radiotherapy; breast cancer; surgical outcomes; tumor downstaging; personalized therapy; breast-conserving surgery; mastectomy; clinical outcomes

(This special issue belongs to the Section Cancer Therapy)

Current Status and Prospects of Multimodal Treatment for Upper Gastrointestinal Cancer

edited by Koichi Okamoto

submission deadline 31 May 2026 | 1 articles | Viewed by 1018 | Submission Open

Keywords: upper gastrointestinal cancer; esophageal cancer; gastric cancer; esophagogastric junction cancer; chemotherapy; oncology; endoscopic resection; minimally invasive surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Nano-Targeting of Cancer

edited by Thomas Ming Swi Chang OC MD CM PhD DSc FRCPC FRSC FCAHS

submission deadline 31 May 2026 | 1 articles | Viewed by 884 | Submission Open

Keywords: drug delivery; artificial intelligence; targeted delivery; nanorobotics; prodrug activation; intracellular action; liposome; PEGylation; nanoparticles; nanocapsules; nanoartificial cells

(This special issue belongs to the Section Cancer Therapy)

Decoding the Dynamic Matrix Complexity in Cancer

edited by

Nikos Karamanos

Zoi Piperigkou

and

Luisa Bracci

submission deadline 31 May 2026 | Viewed by 431 | Submission Open

Keywords: extracellular matrix; cancer pathobiology; 3D spheroids/organoids; modeling tumor microenvironment complexity; matrix-based bioscaffolds; matrix remodeling; cell surface matrix mediators and effectors; matrix degrading enzymes; proteoglycans/glycosaminoglycans; collagen; matrix (glyco)proteins; molecular targeting

(This special issue belongs to the Section Tumor Microenvironment)

Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment

edited by Ewa Robak and

Tadeusz Robak

submission deadline 31 May 2026 | Viewed by 413 | Submission Open

Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia

(This special issue belongs to the Section Molecular Cancer Biology)

Emerging Nanotechnology and Advanced Materials for Cancer Therapy

edited by

Iraj Alipourfard

submission deadline 31 May 2026 | Viewed by 253 | Submission Open

Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

PET/CT in Radiation Oncology

edited by Gurdip Azad and

Gary Cook

submission deadline 31 May 2026 | Viewed by 223 | Submission Open

Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers

edited by

Andrea Belli

, Matteo Serenari and

Benedetto Ielpo

submission deadline 31 May 2026 | Viewed by 192 | Submission Open

Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy

(This special issue belongs to the Section Cancer Therapy)

Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease

edited by

Carlos M. Telleria

submission deadline 31 May 2026 | Viewed by 189 | Submission Open

Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy; quality of life; and prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms

edited by

Kumar Ganesan

and

Kunka Mohanram Ramkumar

submission deadline 31 May 2026 | Viewed by 158 | Submission Open

Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Mutagenesis and DNA Methylation in Aging

edited by Steven S. Smith

submission deadline 31 May 2026 | Viewed by 154 | Submission Open

Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns

(This special issue belongs to the Section Molecular Cancer Biology)

Infectious Agents and Oesophageal Cancer (2nd Edition)

edited by

Shan Rajendra

and Mohammed Rabiei

submission deadline 31 May 2026 | Viewed by 151 | Submission Open

Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma

(This special issue belongs to the Section Infectious Agents and Cancer)

The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine

edited by Aftab Alam

submission deadline 31 May 2026 | Viewed by 151 | Submission Open

Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Head and Neck Cancer: MRI and PET/CT Diagnosis and Surgical Treatment

edited by

Lavinia Manuela Lenghel

submission deadline 31 May 2026 | Viewed by 138 | Submission Open

Keywords: head and neck cancer; MRI; PET/CT; diagnostic imaging; surgical treatment; tumor staging; image-guided surgery; multidisciplinary approach; oncologic outcomes

(This special issue belongs to the Section Cancer Therapy)

Multimodality Management of Sarcomas (2nd Edition)

edited by

Eelco de Bree

submission deadline 31 May 2026 | Viewed by 130 | Submission Open

Keywords: sarcomas; multimodal; pathology; radiology; surgery; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Single-Cell and Spatial Data Analytics in Cancers

edited by

Yu Shyr

and Qi Liu

submission deadline 31 May 2026 | Viewed by 129 | Submission Open

Keywords: single-cell and spatial omics; tumor heterogeneity; tumor progression; tumor microenvironment; cancer immunotherapy

(This special issue belongs to the Section Cancer Informatics and Big Data)

Image-Guided Radiotherapy in Head and Neck Cancer

edited by Petar Suton

submission deadline 31 May 2026 | Viewed by 122 | Submission Open

Keywords: image-guided radiotherapy (IGRT); head and neck cancer; radiation therapy; cone-beam CT (CBCT); adaptive radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Role of Cytokines in Cancer (2nd Edition)

edited by

Venkataswarup Tiriveedhi

submission deadline 31 May 2026 | Viewed by 119 | Submission Open

Keywords: inflammation; tumor microenvironment; cytokines

(This special issue belongs to the Section Tumor Microenvironment)

Targeted Therapy in Gastrointestinal Cancer (2nd Edition)

edited by

Wei Kang

and

Ka Fai To

submission deadline 31 May 2026 | Viewed by 115 | Submission Open

Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development

(This special issue belongs to the Section Cancer Therapy)

Clinical Imaging and Immunotherapy in Cancer Research

edited by

Fabio Sandomenico

submission deadline 31 May 2026 | Viewed by 112 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitors; molecular imaging; tumor microenvironment; artificial intelligence (AI); radiomics

(This special issue belongs to the Section Clinical Research of Cancer)

Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma

edited by

Mark A. Feitelson

submission deadline 31 May 2026 | Viewed by 108 | Submission Open

Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies

(This special issue belongs to the Section Clinical Research of Cancer)

Tumor Microenvironment in Ovarian Cancer Progression, Dissemination, Recurrence: Biology and Therapeutic Opportunities

edited by

Ralf-Peter Czekay

Paul J. Higgins

and

Dong-Joo Cheon

submission deadline 31 May 2026 | Viewed by 104 | Submission Open

Keywords: transperitoneal carcinomatosis; malignant ascites; chemoresistance; metabolic adaptations; regulation of immune response; tumor– stroma interaction; tumor– peritoneal interaction

(This special issue belongs to the Section Tumor Microenvironment)

Three-Dimensional In Vitro Modeling for the Study of Epithelial Cancers

edited by

Sherif M. Karam

and George Wai Cheong Yip

submission deadline 31 May 2026 | Viewed by 100 | Submission Open

Keywords: 3D cancer model; 3D cancer stem cell culture; 3D tumor invasion model; cancer-on-a-chip; cancer spheroids; carcinogenesis organoid model; bioprinted cancer tissue; microfluidic platform for cancer; scaffold-based cancer model

(This special issue belongs to the Section Methods and Technologies Development)

The Pathogenesis and Treatment of Diffuse Midline Glioma

edited by

Amanda Muhs Saratsis

submission deadline 31 May 2026 | Viewed by 82 | Submission Open

Keywords: pediatric brain tumors; diffuse midline glioma; high-grade glioma; H3K27M mutant glioma; liquid biopsy; diffuse intrinsic pontine glioma

(This special issue belongs to the Section Cancer Therapy)

Cellular Senescence, Aging and the Tumor Microenvironment in Cancer

edited by Jabed Iqbal and Jeremy Wee Kiat Ng

submission deadline 31 May 2026 | Viewed by 62 | Submission Open

Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine

edited by

Daniel Gündel

and

Sophie Stotz

submission deadline 31 May 2026 | Viewed by 56 | Submission Open

Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Role of Protein and Metabolite in Cancers

edited by

Md. Wasim Khan

submission deadline 31 May 2026 | Viewed by 55 | Submission Open

Keywords: cancer progression; cancer cells; proteins; metabolites; signaling pathway; metabolic dysregulations

(This special issue belongs to the Section Tumor Microenvironment)

The Advance of Proton Therapy in Head-and-Neck Cancers

edited by

Nancy Lee

and Edward Christopher Dee

submission deadline 31 May 2026 | Viewed by 55 | Submission Open

Keywords: proton therapy; head-and-neck cancer; clinical outcomes; toxicity reduction; multinational studies; reirradiation; skull base tumors; salivary gland cancers; prospective and retrospective cohorts

(This special issue belongs to the Section Cancer Therapy)

Advances in Primary and Secondary Bone and Soft Tissue Tumors

edited by

Frank Traub

submission deadline 31 May 2026 | Viewed by 48 | Submission Open

Keywords: primary bone tumors; soft tissue sarcomas; metastatic bone disease; molecular diagnostics including liquid biopsy; surgical management including reconstruction; immunotherapy; tumor microenvironment; biomarkers and prognostic factors; cancer surveillance; translational oncology

Neuroimaging Biomarkers of Cancer Therapy-Related CNS Complications

edited by Jasmina Boban

submission deadline 31 May 2026 | Viewed by 44 | Submission Open

Keywords: neuroimaging; multimodal imaging; chemotherapy; immunotherapy; chemotherapy-related cognitive dysfunction; drug- related side effects and adverse reactions

Clinical Treatment and Translational Advances in Myelodysplastic Syndromes and Acute Myeloid Leukemia

edited by

Emiliano Fabiani

and

Luca Guarnera

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: myeloid neoplasms; myelodysplastic neoplasms; acute myeloid leukemia; leukemogenesis; target therapy

Toxicities of Antineoplastic Therapies

edited by Ysabella Van Sebille,

Hannah Wardill

and

Connor Williams

submission deadline 31 May 2026 | Viewed by 42 | Submission Open

Keywords: antineoplastic therpay; cancer treatment-related toxicities; cancer treatment adverse events; chemotherapy toxicity; targeted therapy toxicities; immunotherapy toxicity; hormonal therapy toxicity; radiation-induced toxicity; cellular and gene therapy toxicity; supportive cancer care; survivorship; patient-reported outcomes; toxicity management

(This special issue belongs to the Section Cancer Therapy)

Innovations in Colorectal Cancer

edited by Sandy Hwang Fang

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: colon cancer; rectal cancer; innovation; clinical trials; total neoadjuvant therapy; medical oncology; radiation oncology

Advances in Urological Cancer: Innovative Therapies and Biomarkers

edited by Hiroshi Yaegashi

submission deadline 31 May 2026 | Viewed by 40 | Submission Open

Keywords: urological oncology; urothelial cancer; prostate cancer; renal cancer; biomarkers; immunotherapy

Gynecological Cancers: Molecular Insights to Precision Therapy

edited by Gian Franco Zannoni and

Angela Santoro

submission deadline 31 May 2026 | Viewed by 40 | Submission Open

Keywords: gynecological cancers; precision medicine; molecular biomarkers; targeted therapy; tumor microenvironment; immunotherapy; translational oncology

Noncoding RNA and Molecular Mechanisms of Metastasis in Gastrointestinal Cancers

edited by

Kaihong Huang

submission deadline 31 May 2026 | Viewed by 39 | Submission Open

Keywords: noncoding RNA; gastrointestinal cancers; metastasis; molecular mechanisms; microRNA; long noncoding RNA; circular RNA; cancer biology; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Cancer Biology)

The Evolving Role of CDK4/6 Inhibitors in Early and Recurrent Breast Cancer: Clinical and Translational Findings and Work in Progress

edited by Hans-Christian Kolberg

submission deadline 31 May 2026 | Viewed by 35 | Submission Open

Keywords: CDK4/6 inhibitors; breast cancer; treatment resistance; combination therapy; biomarkers

Multiple Myeloma: From Molecular Insights to Clinical Treatments

edited by Mikala Gabor

submission deadline 31 May 2026 | Viewed by 35 | Submission Open

Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation

T-Cell Lymphoma: From Diagnosis to Treatment

edited by Lubomir Sokol and Yumeng Zhang

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: cutaneous T-cell lymphomas (CTCLs); peripheral T-cell lymphomas (PTCLs); Sezary syndrome (SS); mycosis fungoides (MF); genetic; epigenetic; therapeutic strategies

Evolving Role of Surgery in Thoracic Oncology

edited by Inderpal S. Sarkaria and Shamus Carr

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: non-small cell lung cancer; esophageal cancer; thymic epithelial tumors; BAP1 malignant mesothelioma; robotic surgery; immunotherapy; cellular therapies; molecular imaging

Flow Cytometry in Acute Leukemia: From Diagnosis to Disease Monitoring

edited by

Donatella Raspadori

and

Paola Pacelli

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: acute leukemia; ALL; AML; flow cytometry; NGF; leukemia stem cells (LSCs; minimal residual disease (MRD)

(This special issue belongs to the Section Methods and Technologies Development)

Epigenetic Alterations in Human Tumors

edited by Mihalis I. Panayiotidis and

Young Kyung Park

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Adjuvant Therapy and The Cytotoxic Effects in Colorectal Cancers

edited by William H. Gmeiner

submission deadline 31 May 2026 | Viewed by 29 | Submission Open

Keywords: colorectal cancer; adjuvant chemotherapy; targeted therapy; immunotherapy; metastatic colorectal cancer; drug resistance; combination therapy; cytotoxic effects

(This special issue belongs to the Section Cancer Therapy)

Machine Learning and Artificial Intelligence in Leukemia

edited by Garrett M. Dancik and

Spiros Vlahopoulos

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: cancer genomics; genomic sequencing; biomarkers; predictive modeling; machine learning; artificial intelligence; leukemia; computer vision; natural language processing

(This special issue belongs to the Section Methods and Technologies Development)

Multimodality Imaging for More Precise Radiotherapy (2nd Edition)

edited by Stefano Arcangeli,

Denis Panizza

and

Valeria Faccenda

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy

(This special issue belongs to the Section Cancer Therapy)

The Intelligent Scalpel: AI and the Future of Cancer Surgery

edited by Abdallah S. Attia and Kristen E. Limbach

submission deadline 31 May 2026 | Viewed by 24 | Submission Open

Keywords: artificial intelligence; surgical oncology; radiomics; pathomics; robotic surgery; large language models; multimodal learning; explainable AI; precision surgery; ethical AI

(This special issue belongs to the Section Methods and Technologies Development)

Displaying special issue 651-700 on page 14 of 24.

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