Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles

Dear Colleagues,

In the “Topic of Special Interest”, we propose to cover the role of Wnt signaling in cancer, likely with a focus on cancers in solid tumors, especially GI cancers. We will discuss the different driver mutations associated with Wnt-driven cancers (i.e., APC, beta-catenin, Axin, RNF43, etc.) and their association with various cancer types. We plan to also discuss the role of Wnt signaling on the tumor microenvironment and the tumor immune response. Finally, a discussion of efforts to pharmacologically target Wnt signaling to date, including problems and progress, is planned.

Prof. Michael Kahn
Dr. Keane Lai
Guest Editors

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