Artificial Gravity and Neural Rehabilitation: From Mechanisms to Clinical Translation

Dear Colleagues,

Prolonged exposure to microgravity induces profound adaptations in sensorimotor, vestibular, autonomic, and cognitive systems, often leading to balance impairments, spatial disorientation, gait instability, and reduced dual‑task performance. Artificial gravity, typically generated by short‑ or long‑radius centrifugation, has emerged as a promising multisystem countermeasure, providing simultaneous somatosensory and vestibular stimulation that can drive neuroplasticity and support functional recovery. In parallel, neurorehabilitation is rapidly integrating advanced technologies, multimodal assessment, and individualized interventions to address complex motor and cognitive deficits across neurological conditions. This Special Issue aims to bridge space medicine, artificial gravity research, and neural rehabilitation by collecting experimental, clinical, computational, and translational studies. We particularly welcome contributions that elucidate mechanisms, propose novel protocols, or leverage artificial gravity concepts and devices to inform rehabilitation strategies both in analogs of spaceflight and terrestrial patient populations.

Dr. Christos Frantzidis
Dr. Chrysoula Kourtidou-Papadeli
Guest Editors

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