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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems

edited by

Nicolas Joly

Patrick M. Martin

and

Vincent Sol

submission deadline 15 May 2026 | Viewed by 126 | Submission Open

Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies

edited by

Xin Xu

and

Lawrence Rasmussen

submission deadline 16 May 2026 | Viewed by 127 | Submission Open

Keywords: neutrophils; immune regulation; inflammation; infectious diseases; autoimmune disease; tumor

(This special issue belongs to the Section Biological Factors)

Industrial Microorganisms and Enzyme Technologies

edited by

Yunjun Yan

submission deadline 20 May 2026 | 4 articles | Viewed by 4038 | Submission Open

Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism

(This special issue belongs to the Section Enzymology)

Advances in the Structure and Function of Microtubule-Associated Motor Proteins

edited by Arne Gennerich

submission deadline 20 May 2026 | 2 articles | Viewed by 2534 | Submission Open

Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Notch and Its Regulation in Health and Disease

edited by

Martin Baron

submission deadline 20 May 2026 | 1 articles | Viewed by 1143 | Submission Open

Keywords: Notch; signalling; development; diseases

(This special issue belongs to the Section Molecular Medicine)

Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications

edited by Li Fan

submission deadline 23 May 2026 | Viewed by 132 | Submission Open

Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Experimental Validation and Computationally Driven Design of Protein–Protein Interaction Modulators

edited by

Iogann Tolbatov

submission deadline 23 May 2026 | Viewed by 122 | Submission Open

Keywords: protein– protein interactions; peptide modulators; computational drug design; biophysical and cellular assays; molecular docking; molecular dynamics; AI in drug discovery; medicinal chemistry

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Key Mechanisms in the Pathogenesis of ALS

edited by

Natalia N. Ninkina

and

Michail S. Kukharsky

submission deadline 30 May 2026 | Viewed by 46 | Submission Open

Keywords: amyotrophic lateral sclerosis; motor neuron disease; neurodegeneration; pathogenesis; protein aggregation; non-coding RNA; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Tissue Calcification in Normal and Pathological Environments

edited by

Fulvia Ortolani

submission deadline 31 May 2026 | 10 articles | Viewed by 29872 | Submission Open

Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death

(This special issue belongs to the Section Molecular Medicine)

Liver Damage and Associated Metabolic Disorders

edited by

Lin Jia

submission deadline 31 May 2026 | 5 articles | Viewed by 18548 | Submission Open

Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses

(This special issue belongs to the Section Molecular Medicine)

The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research

edited by

Riccardo Fesce

submission deadline 31 May 2026 | 2 articles | Viewed by 14936 | Submission Open

Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Yumin Dai

and

Martina Beretta

submission deadline 31 May 2026 | 4 articles | Viewed by 14147 | Submission Open

Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity

(This special issue belongs to the Section Molecular Medicine)

Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities

edited by

Antonio Garrido

submission deadline 31 May 2026 | 2 articles | Viewed by 8494 | Submission Open

Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition

(This special issue belongs to the Section Biological Factors)

Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders

edited by

Fabio Di Domenico

and

Antonella Tramutola

submission deadline 31 May 2026 | 1 articles | Viewed by 7066 | Submission Open

Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration

(This special issue belongs to the Section Molecular Medicine)

Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 31 May 2026 | 2 articles | Viewed by 6396 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition

edited by

Ana Catarina Fonseca

submission deadline 31 May 2026 | 4 articles | Viewed by 6093 | Submission Open

Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights

edited by

Mykola Mamenko

and Brandi M. Wynne

submission deadline 31 May 2026 | 3 articles | Viewed by 5848 | Submission Open

Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release

(This special issue belongs to the Section Cellular Biochemistry)

Protein Biophysics

edited by

Vladimir N. Uversky

and

Orkid Coskuner-Weber

submission deadline 31 May 2026 | 4 articles | Viewed by 5338 | Submission Open

Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advancing Innovations in Biomedical Research for Translational Applications

edited by Jianjie Ma, Ki Ho Park and

Zui Pan

submission deadline 31 May 2026 | 3 articles | Viewed by 5321 | Submission Open

Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in RNA Editing and Modification

edited by

Toshifumi Tsukahara

submission deadline 31 May 2026 | 2 articles | Viewed by 5003 | Submission Open

Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advances in Metabolomics in Health and Disease

edited by

Carmen Socaciu

submission deadline 31 May 2026 | 3 articles | Viewed by 4086 | Submission Open

Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms in Skin Disorders

edited by

Keiichi Yamanaka

submission deadline 31 May 2026 | 3 articles | Viewed by 4079 | Submission Open

Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ

(This special issue belongs to the Section Molecular Biology)

DNA Damage Repair and Cancer Therapeutics

edited by

Wenjing Li

submission deadline 31 May 2026 | 2 articles | Viewed by 2133 | Submission Open

Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular Mechanisms and Therapeutic Strategies for Metabolic Dysfunction: From Molecules to Population Health

edited by

Zhipeng Liu

submission deadline 31 May 2026 | 2 articles | Viewed by 2058 | Submission Open

Keywords: metabolic dysfunction; molecular mechanisms; therapeutic strategies; genomics; genetic epidemiology; comorbidities; biomarkers

Cutting-Edge Perspectives on Protein and Enzyme Engineering

edited by Haishan Qi and Haoran Yu

submission deadline 31 May 2026 | 1 articles | Viewed by 2024 | Submission Open

Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Obesity, Hormones and Reproductive Health

edited by

Srinivas Nammi

submission deadline 31 May 2026 | 1 articles | Viewed by 1965 | Submission Open

Keywords: obesity; leptin; insulin; estrogens; androgens; growth hormone; sexual dysfunction; reproductive health

(This special issue belongs to the Section Biological Factors)

Impact of Systemic Inflammation on Neuroinflammation, Neurodegenerative Diseases and Mental Disorders

edited by

Raymond Chuen-Chung Chang

submission deadline 31 May 2026 | 1 articles | Viewed by 1899 | Submission Open

Keywords: systemic inflammation; neuroinflammation diseases; neurodegenerative diseases; mental disorders

(This special issue belongs to the Section Molecular Medicine)

Acute Kidney Injury and Mitochondrial Involvement

edited by

Iva Suman

and Alenka Višnić

submission deadline 31 May 2026 | 1 articles | Viewed by 1867 | Submission Open

Keywords: acute kidney injury; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; biomarkers

(This special issue belongs to the Section Chemical Biology)

Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics

edited by

Dennis R. Grayson

and

Jacob Peedicayil

submission deadline 31 May 2026 | 1 articles | Viewed by 1653 | Submission Open

Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics

(This special issue belongs to the Section Molecular Genetics)

Advances in Microbial CRISPR Editing

edited by

Dongdong Yang

and Rongming Liu

submission deadline 31 May 2026 | 1 articles | Viewed by 1357 | Submission Open

Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems

(This special issue belongs to the Section Molecular Biology)

Advances in Membrane Proteins: From Structure to Function and Molecular Engineering

edited by

Ximin Chi

and Renhong Yan

submission deadline 31 May 2026 | 2 articles | Viewed by 1257 | Submission Open

Keywords: membrane transport; transmembrane signaling; membrane protein complex; membrane-based reactions; membrane and protein interaction; regulation of membrane proteins; membrane protein design; membrane protein engineering

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Dysregulated Cytokine Signals in Human Disease

edited by

Alister C. Ward

submission deadline 31 May 2026 | 1 articles | Viewed by 1228 | Submission Open

Keywords: cytokine; signaling; dysregulation; immunity; development; disease

(This special issue belongs to the Section Molecular Medicine)

New Insight into the Structures and Host Cell Interactions of Emerging Viruses

edited by

Wei Zhang

and

Qibin Geng

submission deadline 31 May 2026 | 1 articles | Viewed by 706 | Submission Open

Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus– host interactions; viral receptor binding and entry; viral assembly; maturation; and egress; immune evasion; molecular dynamics simulation; antiviral targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Pediatric Epilepsy: Insights from Genetics to Mechanisms

edited by Denise Drongitis and

Maria Giuseppina Miano

submission deadline 31 May 2026 | Viewed by 463 | Submission Open

Keywords: integrative omics; organoid models; brain development; PE-related pathways; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Genetics)

Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke

edited by

Yuchuan Ding

submission deadline 31 May 2026 | Viewed by 422 | Submission Open

Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms Underlying Liver Diseases: 2nd Edition

edited by

Wei Zhong

submission deadline 31 May 2026 | Viewed by 330 | Submission Open

Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights

(This special issue belongs to the Section Cellular Biochemistry)

Assembly of RNA and DNA

edited by

Roman Marks

and

Jürg Bähler

submission deadline 31 May 2026 | Viewed by 273 | Submission Open

Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules

(This special issue belongs to the Section Molecular Genetics)

Metabolic and Signal Transduction Pathways Controlling Platelet and Megakaryocyte Activity

edited by Ana Kasirer-Friede and Deepa Gautam

submission deadline 31 May 2026 | Viewed by 273 | Submission Open

Keywords: platelet; megakaryocyte; signaling; omics; immune

(This special issue belongs to the Section Molecular Biology)

Botanic Metabolites: From Extraction to Application

edited by

Carmen Formisano

submission deadline 31 May 2026 | Viewed by 236 | Submission Open

Keywords: medicinal plants; phytochemistry; antimicrobial activity; plant extracts; essential oils; synergism

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini, 2nd Edition

edited by

Marija Meznaric

Daniela Tavian

and

Sara Missaglia

submission deadline 31 May 2026 | Viewed by 205 | Submission Open

Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies

(This special issue belongs to the Section Molecular Biology)

The Role of Amyloid in Neurological Disorders: 2nd Edition

edited by

Marny Fedrigo

and Tamara Berno

submission deadline 31 May 2026 | Viewed by 179 | Submission Open

Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid interaction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Artificial Intelligence in Structural Biology and Drug Discovery

edited by Kyle Biggar

submission deadline 31 May 2026 | Viewed by 157 | Submission Open

Keywords: protein structure prediction; drug discovery; molecular docking; experimental validation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Immune Microenvironment in Cancer: Myeloid Cells and Therapeutic Insights

edited by

Daniëlle Krijgsman

submission deadline 31 May 2026 | Viewed by 148 | Submission Open

Keywords: cancer; immunotherapy; myeloid cells; macrophages; neutrophils; tumor microenvironment; therapy resistance

(This special issue belongs to the Section Molecular Medicine)

Molecular Docking and Dynamics in Drug Discovery

edited by

Črtomir Podlipnik

submission deadline 31 May 2026 | Viewed by 144 | Submission Open

Keywords: molecular docking; molecular dynamics (MD); structure-based drug design (SBDD); computational drug discovery; open science

(This special issue belongs to the Section Chemical Biology)

Symbiotic Systems and Viral Diversity: From Marine Organisms to Human Pathogenesis

edited by

Padmanabhan Mahadevan

submission deadline 31 May 2026 | Viewed by 131 | Submission Open

Keywords: viral diversity; virome; symbiosis; genomics; pathogenesis; metagenomics; sequencing

Molecular Mechanisms of Viral Infections—2nd Edition

edited by

Ioannis Karakasiliotis

Christine Kottaridi

and

Konstantinos Konstantinidis

submission deadline 31 May 2026 | Viewed by 128 | Submission Open

Keywords: viral replication; virus evolution; immune response; antiviral strategies virus; infection; pathogenesis; virulence

(This special issue belongs to the Section Molecular Biology)

Molecular Engineering and Applications of Protein Cages and Cavities

edited by

John F. Honek

submission deadline 31 May 2026 | Viewed by 121 | Submission Open

Keywords: host-guest encapsulation; drug targeting; virus-like nanoparticles; ferritins; cavity-containing biomolecules; vault proteins; encapsulins; nanocompartments; medicinal; materials science; and analytical applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advances and Emerging Strategies in Gene Therapy

edited by Xin Chen

submission deadline 31 May 2026 | Viewed by 109 | Submission Open

Keywords: AAV; gene-editing; base editing; prime editing; RNA editing; lipid nanoparticles; liposomes; exosomes; tRNA therapy; small activating RNAs

(This special issue belongs to the Section Molecular Medicine)

Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications

edited by