Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

Section
Search by Title/Keyword
 
Order results
Display
Results per page
Notch and Its Regulation in Health and Disease
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1638 | Submission Open
Keywords: Notch; signalling; development; diseases
(This special issue belongs to the Section Molecular Medicine)
Helicases in DNA Repair: From Molecular Mechanisms to Medical and Biotechnological Applications
edited by Li Fan
submission deadline 23 May 2026 | 1 articles | Viewed by 1247 | Submission Open
Keywords: DNA unwinding; DNA damage response; damage verification; genetic disease; premature aging; cancer; chemotherapy; gene therapy
(This special issue belongs to the Section Molecular Genetics)
Tissue Calcification in Normal and Pathological Environments
edited by
submission deadline 31 May 2026 | 10 articles | Viewed by 38483 | Submission Open
Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death
(This special issue belongs to the Section Molecular Medicine)
Liver Damage and Associated Metabolic Disorders
edited by
submission deadline 31 May 2026 | 5 articles | Viewed by 23338 | Submission Open
Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses
(This special issue belongs to the Section Molecular Medicine)
The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 20163 | Submission Open
Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by and
submission deadline 31 May 2026 | 4 articles | Viewed by 17753 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity
(This special issue belongs to the Section Molecular Medicine)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 10721 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
(This special issue belongs to the Section Biological Factors)
Advances in Metabolomics in Health and Disease
edited by
submission deadline 31 May 2026 | 5 articles | Viewed by 9491 | Submission Open
Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics
(This special issue belongs to the Section Molecular Medicine)
Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights
edited by and Brandi M. Wynne
submission deadline 31 May 2026 | 3 articles | Viewed by 9313 | Submission Open
Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release
(This special issue belongs to the Section Cellular Biochemistry)
Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 9167 | Submission Open
Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases
(This special issue belongs to the Section Molecular Medicine)
Advancing Innovations in Biomedical Research for Translational Applications
edited by Jianjie Ma, and
submission deadline 31 May 2026 | 6 articles | Viewed by 9103 | Submission Open
Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission
(This special issue belongs to the Section Molecular Medicine)
Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders submission deadline 31 May 2026 | 1 articles | Viewed by 8740 | Submission Open
Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration
(This special issue belongs to the Section Molecular Medicine)
Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition submission deadline 31 May 2026 | 5 articles | Viewed by 8052 | Submission Open
Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis
(This special issue belongs to the Section Molecular Biomarkers)
Recent Advances in RNA Editing and Modification submission deadline 31 May 2026 | 2 articles | Viewed by 6206 | Submission Open
Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular and Cellular Mechanisms in Skin Disorders
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 5803 | Submission Open
Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ
(This special issue belongs to the Section Molecular Biology)
Acute Kidney Injury and Mitochondrial Involvement
edited by and
submission deadline 31 May 2026 | 4 articles | Viewed by 5488 | Submission Open
Keywords: acute kidney injury; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; biomarkers
(This special issue belongs to the Section Chemical Biology)
Cutting-Edge Perspectives on Protein and Enzyme Engineering
edited by Haishan Qi and Haoran Yu
submission deadline 31 May 2026 | 2 articles | Viewed by 3882 | Submission Open
Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
New Insight into the Structures and Host Cell Interactions of Emerging Viruses
edited by and
submission deadline 31 May 2026 | 3 articles | Viewed by 3493 | Submission Open
Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus– host interactions; viral receptor binding and entry; viral assembly; maturation; and egress; immune evasion; molecular dynamics simulation; antiviral targets
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Molecular Mechanisms and Therapeutic Strategies for Metabolic Dysfunction: From Molecules to Population Health
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 3250 | Submission Open
Keywords: metabolic dysfunction; molecular mechanisms; therapeutic strategies; genomics; genetic epidemiology; comorbidities; biomarkers
Advances in Microbial CRISPR Editing
edited by and Rongming Liu
submission deadline 31 May 2026 | 2 articles | Viewed by 3037 | Submission Open
Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems
(This special issue belongs to the Section Molecular Biology)
Obesity, Hormones and Reproductive Health
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 2742 | Submission Open
Keywords: obesity; leptin; insulin; estrogens; androgens; growth hormone; sexual dysfunction; reproductive health
(This special issue belongs to the Section Biological Factors)
Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 2733 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Nitric Oxide and Reactive Species in Plant Physiology and Pathology
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 2435 | Submission Open
Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation
(This special issue belongs to the Section Biological Factors)
Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics submission deadline 31 May 2026 | 1 articles | Viewed by 2163 | Submission Open
Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics
(This special issue belongs to the Section Molecular Genetics)
Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications
edited by and Anthea Miller
submission deadline 31 May 2026 | 2 articles | Viewed by 1947 | Submission Open
Keywords: inflammation; innate immunity; therapeutic targets; immune signaling pathways; pattern-recognition receptors (PRRs)
(This special issue belongs to the Section Molecular Medicine)
Genomic Instability: Insights into Molecular Mechanisms, Human Diseases, and Therapies
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 1939 | Submission Open
Keywords: genome instability; DNA damage response; cancer; therapy; diagnosis
(This special issue belongs to the Section Molecular Genetics)
Botanic Metabolites: From Extraction to Application
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 1508 | Submission Open
Keywords: medicinal plants; phytochemistry; antimicrobial activity; plant extracts; essential oils; synergism
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 1302 | Submission Open
Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases
(This special issue belongs to the Section Molecular Medicine)
Cellular Stress, Inflammation, and Metabolic Dysfunction in the Progression of MASLD
edited by Weber Andre Alberto
submission deadline 31 May 2026 | 1 articles | Viewed by 674 | Submission Open
Keywords: MASLD; fibrosis; liver; hepatosteatosis; endoplasmic reticulum stress
(This special issue belongs to the Section Molecular Medicine)
Pediatric Epilepsy: Insights from Genetics to Mechanisms
edited by Denise Drongitis and
submission deadline 31 May 2026 | Viewed by 580 | Submission Open
Keywords: integrative omics; organoid models; brain development; PE-related pathways; innovative therapeutic approaches
(This special issue belongs to the Section Molecular Genetics)
Metabolic and Signal Transduction Pathways Controlling Platelet and Megakaryocyte Activity
edited by Ana Kasirer-Friede and Deepa Gautam
submission deadline 31 May 2026 | Viewed by 469 | Submission Open
Keywords: platelet; megakaryocyte; signaling; omics; immune
(This special issue belongs to the Section Molecular Biology)
Assembly of RNA and DNA
edited by and
submission deadline 31 May 2026 | Viewed by 450 | Submission Open
Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules
(This special issue belongs to the Section Molecular Genetics)
Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini, 2nd Edition submission deadline 31 May 2026 | Viewed by 429 | Submission Open
Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies
(This special issue belongs to the Section Molecular Biology)
Artificial Intelligence in Structural Biology and Drug Discovery
edited by Kyle Biggar
submission deadline 31 May 2026 | Viewed by 359 | Submission Open
Keywords: protein structure prediction; drug discovery; molecular docking; experimental validation
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Molecular Mechanisms of Viral Infections—2nd Edition submission deadline 31 May 2026 | Viewed by 310 | Submission Open
Keywords: viral replication; virus evolution; immune response; antiviral strategies virus; infection; pathogenesis; virulence
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnostics and Targeted Therapies for Breast and Prostate Cancers
edited by , Ekaterina Bezverkhniaia and Panagiotis Kanellopoulos
submission deadline 31 May 2026 | Viewed by 275 | Submission Open
Keywords: molecular imaging; targeted therapy; prostate cancer; breast cancer; theranostics
(This special issue belongs to the Section Biological Factors)
Molecular Motors in Muscle: From Single Molecules to Tissue Function
edited by
submission deadline 31 May 2026 | Viewed by 269 | Submission Open
Keywords: molecular motors; muscle mechanics; motor protein energetics; cytoskeletal dynamics; single-molecule biophysics  
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Immune Microenvironment in Cancer: Myeloid Cells and Therapeutic Insights submission deadline 31 May 2026 | Viewed by 259 | Submission Open
Keywords: cancer; immunotherapy; myeloid cells; macrophages; neutrophils; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms of Oocyte and Early Embryo Development: RNA Regulation and Epigenetic Modifications submission deadline 31 May 2026 | Viewed by 258 | Submission Open
Keywords: oocyte; embryo development; follicular development; RNA regulation; epigenetic modifications
(This special issue belongs to the Section Molecular Reproduction)
Genetic Variations and Gene Expression in Diseases
edited by
submission deadline 31 May 2026 | Viewed by 235 | Submission Open
Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis
(This special issue belongs to the Section Molecular Biology)
Advances and Emerging Strategies in Gene Therapy
edited by Xin Chen
submission deadline 31 May 2026 | Viewed by 232 | Submission Open
Keywords: AAV; gene-editing; base editing; prime editing; RNA editing; lipid nanoparticles; liposomes; exosomes; tRNA therapy; small activating RNAs
(This special issue belongs to the Section Molecular Medicine)
Advances in Cardiometabolic Health, 2nd Edition
edited by Pamela Senesi and
submission deadline 31 May 2026 | Viewed by 232 | Submission Open
Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Research on Autoimmune Diseases: From Diagnosis to Therapy
edited by
submission deadline 31 May 2026 | Viewed by 230 | Submission Open
Keywords: systemic sclerosis; autoimmune diseases; rheumatic diseases; chronic inflammation; mechanisms
(This special issue belongs to the Section Biological Factors)
Metagenomics and Genomics of Marine Organisms submission deadline 31 May 2026 | Viewed by 227 | Submission Open
Keywords: metagenomics genomics viruses bacteria symbiosis microbiome
Molecular Pathogenesis and Emerging Therapeutic Targets and Strategies in Huntington’s Disease
edited by and
submission deadline 31 May 2026 | Viewed by 194 | Submission Open
Keywords: Huntington’ s disease; huntingtin; polyglutamine; neurodegeneration; pathogenesis; therapeutic targets; proteopathy; autophagy dysfunction; transcriptional dysregulation; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Medicine)
Advances in Nano-Based Drug Delivery Systems submission deadline 1 Jun 2026 | 6 articles | Viewed by 12121 | Submission Open
Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules
(This special issue belongs to the Section Molecular Medicine)
Emerging Bioactives from Underexplored Botanical Sources and By-Products for Food Applications
edited by Suelen Pereira Ruiz Herrig, Zilda Cristiani Gazim and Beatriz Cervejeira Bolanho Barros
submission deadline 1 Jun 2026 | Viewed by 216 | Submission Open
Keywords: botanical bioactives; by-products; natural food additives; green extraction
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Aldehyde Metabolism and Innate Immune Signaling in Cardiovascular Disease: From Pathogenesis to Regeneration
edited by Suresh S. Palaniyandi
submission deadline 1 Jun 2026 | Viewed by 214 | Submission Open
Keywords: reactive aldehydes (4-HNE; acrolein; and malondialdehyde); lipid peroxidation and oxidative stress; aldehyde detoxification enzymes (ALDH2; ALDHs; AKRs; and GSTs); glutathione and antioxidant defense systems; mitochondrial dysfunction and redox imbalance; protein adducts and cellular signaling; endothelial dysfunction and vascular injury; inflammation; innate immunity; and inflammasomes; cardiac remodeling; heart failure; and atherosclerosis; biomarkers and therapeutic strategies (enzyme activators; scavengers; and regeneration)
(This special issue belongs to the Section Molecular Medicine)
Defects in the Transport Mechanism of Membrane Proteins and Related Diseases, 2nd Edition
edited by Daniela Valeria Miniero
submission deadline 10 Jun 2026 | 3 articles | Viewed by 5802 | Submission Open
Keywords: function; structure and folding of membrane transport proteins; pathological mutations; mechanism of transport; neurological and metabolic disease; transport of nanoparticles; organelle membranes; cellular function and signaling; bioenergetics; neuroinflammation; nanoformulations for drug targets
(This special issue belongs to the Section Cellular Biochemistry)
Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition
edited by , and Haiting Chai
submission deadline 15 Jun 2026 | 4 articles | Viewed by 10274 | Submission Open
Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Back to TopTop