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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Molecular Mechanisms and Therapeutics for Malaria

edited by

Maria Isabel Veiga

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5964 | Submission Open

Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in the Enzymatic Synthesis of Bioactive Compounds

edited by

Bartłomiej Zieniuk

submission deadline 31 Dec 2025 | 5 articles | Viewed by 5773 | Submission Open

Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5759 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Biomarkers in Cardiology 2025

edited by

Pietro Scicchitano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5635 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart

(This special issue belongs to the Section Molecular Biomarkers)

Chemical Biology and Biotechnology of Nucleosides, Nucleotides, and Nucleic Acids

edited by

Xingguo Liang

and

Xinjing Tang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5438 | Submission Open

Keywords: nucleosides; nucleotides; nanostructure; circular ssDNA; circular RNA; quadruplex; conjugate; lncRNA; DNAzyme; ribozyme

(This special issue belongs to the Section Chemical Biology)

Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials

edited by

Mire Zloh

and

Rachael Dickman

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5173 | Submission Open

Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Gametogenesis and Gamete Interaction, 2nd Edition

edited by

Hitoshi Sawada

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5162 | Submission Open

Keywords: gametogenesis and meiosis; sperm attraction and activation; gamete interaction and recognition; species specificity and self/nonself-recognition in hermaphrodites; acrosome reaction sperm penetration of egg coat; gamete membrane fusion; polyspermy block; egg activation

(This special issue belongs to the Section Molecular Reproduction)

Signaling Pathways as Therapeutic Targets for Cancer

edited by Fabian Benencia

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5051 | Submission Open

Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies

(This special issue belongs to the Section Molecular Biology)

Necrotic Cell Death Mechanisms and Therapies

edited by

Ilana Nathan

and

Boris Khalfin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5024 | Submission Open

Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis

(This special issue belongs to the Section Cellular Biochemistry)

Neuron–Astrocyte Interactions in Neurological Function and Disease

edited by Micaela Zonta and Alessandro Di Spiezio

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4955 | Submission Open

Keywords: astrocytes; neuron-astrocyte communication; brain function; neurological disease

(This special issue belongs to the Section Molecular Medicine)

Calcium Signaling in Cell Function and Dysfunction

edited by

Giorgia Pallafacchina

and Sofia Zanin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4700 | Submission Open

Keywords: calcium signaling; calcium regulation; cell function; human pathology

(This special issue belongs to the Section Molecular Biology)

Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability

edited by

Peter Celec

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4530 | Submission Open

Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Neuroinflammation in Ocular Diseases: Emerging Insights into Mechanisms, Biomarkers, and Therapeutic Targets

edited by

S. Priya Narayanan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4136 | Submission Open

Keywords: neuroinflammation; vision; retina; optic nerve; neurodegeneration; inflammation; biomarker; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Biomarkers)

Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities

edited by

Natalia Osna

and

Kusum K. Kharbanda

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4134 | Submission Open

Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD

(This special issue belongs to the Section Molecular Medicine)

Tumour Suppressor Genes: The Guardians of Cell Integrity

edited by

Nicola Manfrini

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3959 | Submission Open

Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy

(This special issue belongs to the Section Molecular Biology)

Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications

edited by

Agata Pomorska

Aneta Michna

and

Maria Morga

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3745 | Submission Open

Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Mechanosensitivity and Ion Channels

edited by Olivia García-Suarez and Yolanda García-Mesa

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3727 | Submission Open

Keywords: mechanosensation; piezo ion channels; mechanosensitivity ion channels; mechanotrasduction

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Novel Mechanisms of Bacterial Antibiotic Resistance

edited by

Dorothea K. Thompson

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3140 | Submission Open

Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches

(This special issue belongs to the Section Biological Factors)

Functional Peptides and Their Interactions (3rd Edition)

edited by

Mikhail Soloviev

and

Simon M. Cutting

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2728 | Submission Open

Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

The Role of Calcium Signaling in Cardiac and Skeletal Muscle

edited by

Andreas Rinne

and

Florentina Pluteanu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2608 | Submission Open

Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Pathogenesis in Autoimmune Diseases

edited by

I-Tsu Chyuan

and

Chi-Jung Huang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2543 | Submission Open

Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications

edited by Yalin Qi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2516 | Submission Open

Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection

(This special issue belongs to the Section Chemical Biology)

Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism

edited by

Katsuhiko Suzuki

and

Kayvan Khoramipour

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2248 | Submission Open

Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Chromatin and Chromosome Molecular Research

edited by Xin Bi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2066 | Submission Open

Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1969 | Submission Open

Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning

(This special issue belongs to the Section Chemical Biology)

Biomolecules in Myocarditis and Inflammatory Heart Disease

edited by

Amarylis Wanschel

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1650 | Submission Open

Keywords: cardiomyocyte; macrophage; cardiac remodeling; oxidative and nitrosative stress; neutrophils

(This special issue belongs to the Section Molecular Medicine)

Molecular Basis of Mast Cells Activation and Medical Implications

edited by

Grzegorz Porebski

and

Matija Rijavec

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1630 | Submission Open

Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms

(This special issue belongs to the Section Biological Factors)

Molecular Basis and Oxidative Stress of Thyroid Diseases

edited by

Małgorzata Karbownik-Lewińska

and

Jan Stȩpniak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1574 | Submission Open

Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease

(This special issue belongs to the Section Biological Factors)

Vertebrate Comparative Genomics

edited by Ya-Xiong Tao and

Shan He

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1550 | Submission Open

Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene

(This special issue belongs to the Section Molecular Genetics)

State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia

edited by

Xuanyu Meng

and

Ruhong Zhou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1516 | Submission Open

Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning

(This special issue belongs to the Section Chemical Biology)

Ion Channels in Cardiovascular and Metabolic Diseases

edited by

Shang-Zhong Xu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1389 | Submission Open

Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters

(This special issue belongs to the Section Biological Factors)

T Cell Ca²⁺ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies

edited by David W. Thomas and

Marc André Lécuyer

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1194 | Submission Open

Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition

edited by

Grzegorz Janusz

and

Anna Pawlik

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1178 | Submission Open

Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering

(This special issue belongs to the Section Enzymology)

Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications

edited by

Marina Piscopo

and

Carmen Di Giovanni

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1164 | Submission Open

Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine

(This special issue belongs to the Section Cellular Biochemistry)

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

edited by

Eun-Woo Lee

and Jiho Yoo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1040 | Submission Open

Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition

edited by

Juei-Tang Cheng

submission deadline 31 Dec 2025 | 1 articles | Viewed by 935 | Submission Open

Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health

The Value of Natural Compounds as Therapeutic Agents: 3rd Edition

edited by

Maria Beatrice Morelli

submission deadline 31 Dec 2025 | 1 articles | Viewed by 913 | Submission Open

Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals

edited by

Monika Pitucha

and

Marta Rusek

submission deadline 31 Dec 2025 | 1 articles | Viewed by 896 | Submission Open

Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry

(This special issue belongs to the Section Chemical Biology)

Phytohormones 2024–2025

edited by Guzel Kudoyarova

submission deadline 31 Dec 2025 | Viewed by 851 | Submission Open

Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Immune Response to Allergens

edited by

Brigita Gradauskiene

submission deadline 31 Dec 2025 | Viewed by 850 | Submission Open

Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Computational Biology of Intrinsically Disordered Proteins

edited by

Paul Harrison

submission deadline 31 Dec 2025 | 1 articles | Viewed by 840 | Submission Open

Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Feature Papers in Molecular Biology Section 2025

edited by

Claudia Tanja Mierke

submission deadline 31 Dec 2025 | 1 articles | Viewed by 722 | Submission Open

Keywords: mechanobiology; cellular processes including metabolism; proliferation and motility; molecular motors and forces; molecular and biophysical techniques; organelle and membrane transport; exo- and endosomal trafficking; cell and biophysical signal transduction; the biomolecular synthesis of proteins; protein folding and post-translational modification of proteins and macromolecular assemblies

(This special issue belongs to the Section Molecular Biology)

Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress

edited by

Hakim Manghwar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 476 | Submission Open

Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research

(This special issue belongs to the Section Molecular Biology)

The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication

edited by

Yuqian Yan

submission deadline 31 Dec 2025 | Viewed by 409 | Submission Open

Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis

(This special issue belongs to the Section Cellular Biochemistry)

Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications

edited by

Sara Missaglia

and Eleonora Martegani

submission deadline 31 Dec 2025 | Viewed by 407 | Submission Open

Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits

(This special issue belongs to the Section Molecular Biology)

Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches

edited by

Milica Perišić Nanut

submission deadline 31 Dec 2025 | Viewed by 353 | Submission Open

Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors

(This special issue belongs to the Section Molecular Biology)

Recent Developments in Organometallic Syntheses for Biomedical Applications

edited by Bala Moku

submission deadline 31 Dec 2025 | Viewed by 335 | Submission Open

Keywords: advanced organometallic syntheses; biomedical applications; drug discovery; disease treatment; imaging; targeted therapy

(This special issue belongs to the Section Molecular Medicine)

Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 31 Dec 2025 | Viewed by 334 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

Sjogren’s Syndrome: Recent Updates and Perspectives

edited by