Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Retinal Diseases: Molecular Mechanisms and Therapies
edited by and Raquel Boia
submission deadline 31 Jan 2026 | 3 articles | Viewed by 8609 | Submission Open
Keywords: retinal diseases; molecular mechanisms; therapeutic strategies; vision impairment; gene therapy; retinal degeneration; neuroprotection; innovative treatments
(This special issue belongs to the Section Cellular Biochemistry)
Pharmacology of Cardiovascular Diseases
edited by , Alexandra Gyongyosi and
submission deadline 31 Jan 2026 | 3 articles | Viewed by 8124 | Submission Open
Keywords: cardioprotection autophagy; redox balance; heart faliure; cardiovascular pharmacotherapy
(This special issue belongs to the Section Molecular Medicine)
Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders
edited by and Salvatore Fioriniello
submission deadline 31 Jan 2026 | 2 articles | Viewed by 5282 | Submission Open
Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic; prognostic and therapeutic approaches for chromatin disorders
(This special issue belongs to the Section Molecular Medicine)
Neurodevelopmental Disorders: Genetic Studies and Therapeutic Strategies
edited by and Bruno Bontempi
submission deadline 31 Jan 2026 | 2 articles | Viewed by 5054 | Submission Open
Keywords: mouse models; Autism Spectrum disorder; transgenic rodents; pharmacological treatments; gene-environment interactions; neurodevelopmental disorders; rare diseases
(This special issue belongs to the Section Molecular Genetics)
Advances and Novel Strategies for Studying Underexplored Post-Translational Modifications (PTMs)
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4471 | Submission Open
Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging
(This special issue belongs to the Section Molecular Biology)
New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition
edited by , and Tarun W. Dasari
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4398 | Submission Open
Keywords: brain– heart axis; heart and stroke; stress-induced cardiomyopathy; cardiovascular disease
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Novel Treatments of Stroke
edited by and Naseem Akhter
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4366 | Submission Open
Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches
(This special issue belongs to the Section Molecular Biology)
Pluripotent Stem Cells: From Basic Research to Therapeutic Applications submission deadline 31 Jan 2026 | 1 articles | Viewed by 3796 | Submission Open
Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications
(This special issue belongs to the Section Molecular Biology)
Natural Products and Their Derivatives with Antiviral Activity
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 3541 | Submission Open
Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Key Molecules Regulating Plant Response to Abiotic Stress: Transcription Factors and Stress-Induced Proteins
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2405 | Submission Open
Keywords: abiotic stress response; transcription factors; stress-induced proteins; molecular mechanisms; transcriptomics; omics; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Current Advances of Metal Complexes for Biomedical Applications submission deadline 31 Jan 2026 | 1 articles | Viewed by 2264 | Submission Open
Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications
(This special issue belongs to the Section Chemical Biology)
Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2004 | Submission Open
Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems
(This special issue belongs to the Section Cellular Biochemistry)
Pathogenesis and Targeted Therapy of Neurodegenerative Diseases submission deadline 31 Jan 2026 | 1 articles | Viewed by 1798 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments
(This special issue belongs to the Section Molecular Medicine)
State-of-the-Art Protein X-Ray Crystallography
edited by Wu-Pei Su and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1619 | Submission Open
Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders
edited by and Anita Racetin
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1538 | Submission Open
Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets
(This special issue belongs to the Section Molecular Medicine)
Lung Disease: From Molecular Mechanism to Therapeutic Opportunities
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1411 | Submission Open
Keywords: biomarkers; pharmacotherapeutics; cell signaling; innate immunity; inflammation
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Basis of Parasite Infection submission deadline 31 Jan 2026 | 1 articles | Viewed by 1182 | Submission Open
Keywords: parasite infection; host– parasite interaction; cellular invasion; molecular mechanisms; immune evasion
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer
edited by Panneerdoss Subbarayalu
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1087 | Submission Open
Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis
(This special issue belongs to the Section Molecular Medicine)
Synthesis, Characterization and Validation of Small Molecule Compounds
edited by Mohamed Fares Metwaly
submission deadline 31 Jan 2026 | 1 articles | Viewed by 957 | Submission Open
Keywords: medicinal chemistry; structure-based drug design; enzyme inhibitors; multi-target therapeutics
(This special issue belongs to the Section Molecular Biology)
Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms submission deadline 31 Jan 2026 | 1 articles | Viewed by 830 | Submission Open
Keywords: alcohol; ethanol metabolism; ethanol– protein interactions; ethanol– membrane interactions; cardiovascular health and disease
(This special issue belongs to the Section Molecular Medicine)
New Insights into Mesothelial Cells
edited by Francesca Bodega and Cristina Porta
submission deadline 31 Jan 2026 | 1 articles | Viewed by 595 | Submission Open
Keywords: mesothelial cells; serous cavities; lubricating fluids; epithelial– mesenchymal transition; fibrosis; tissue repair; mesothelioma; tumor microenvironment; immune response
(This special issue belongs to the Section Molecular Biology)
Inflammation Biology in Orthodontic Tooth Movement
edited by
submission deadline 31 Jan 2026 | Viewed by 413 | Submission Open
Keywords: orthodontic tooth movement; inflammation; cytokine; root resorption; accelerated orthodontic tooth movement; relapse
(This special issue belongs to the Section Biological Factors)
Mechanisms of Gene Regulation in Embryos
edited by and Adam Davis
submission deadline 31 Jan 2026 | Viewed by 358 | Submission Open
Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Therapy Targeting DNA Damage and Repair Systems
edited by , and Anahita Mojiri
submission deadline 31 Jan 2026 | Viewed by 345 | Submission Open
Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis
(This special issue belongs to the Section Biological Factors)
The Role of Extracellular Vesicles in Drug Delivery
edited by
submission deadline 31 Jan 2026 | Viewed by 318 | Submission Open
Keywords: extracellular vesicles; drug delivery systems; extracellular vesicle engineering; cancer treatment; gene therapy
(This special issue belongs to the Section Molecular Biology)
Focus on Perineural Invasion in Pancreatic Cancer
edited by
submission deadline 31 Jan 2026 | Viewed by 310 | Submission Open
Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins
(This special issue belongs to the Section Molecular Medicine)
Genomics and Molecular Biology of Solid Tumors
edited by Dragoş Creţoiu and Silviu Cristian Voinea
submission deadline 31 Jan 2026 | Viewed by 305 | Submission Open
Keywords: solid tumors; tumor microenvironment; genomic instability; cancer stem cells; liquid biopsy
(This special issue belongs to the Section Molecular Biology)
Metabolic Diseases: From Molecular Mechanisms to Therapy Strategies submission deadline 31 Jan 2026 | Viewed by 265 | Submission Open
Keywords: inborn errors of metabolism; molecular mechanisms; gene identification; therapeutic; approaches; translation
Molecular Biology and Therapy of Breast Cancer
edited by
submission deadline 31 Jan 2026 | Viewed by 225 | Submission Open
Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA
Nucleic Acid-Lipid Interactions: Bridging Molecular Insights with Therapeutic Applications
edited by Weiwei He and Serdal Kirmizialtin
submission deadline 31 Jan 2026 | Viewed by 214 | Submission Open
Keywords: nucleic acids; lipid membranes; interactions; structural transitions; physical mechanism
Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease submission deadline 31 Jan 2026 | Viewed by 212 | Submission Open
Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation
(This special issue belongs to the Section Molecular Biology)
Endometriosis: Molecular Pathogenesis and Translational Implications
edited by
submission deadline 31 Jan 2026 | Viewed by 172 | Submission Open
Keywords: endometriosis; pathogenesis; adenomyosis; diagnosis; detection
(This special issue belongs to the Section Molecular Medicine)
Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders
edited by
submission deadline 31 Jan 2026 | Viewed by 157 | Submission Open
Keywords: neurodevelopmental disorders; epigenetics; gene– environment interaction; chromatin remodeling; neurogenomics
(This special issue belongs to the Section Molecular Genetics)
Mechanisms in Stress-Related Disorders, Anxiety and Fear
edited by Veronica Begni
submission deadline 31 Jan 2026 | Viewed by 151 | Submission Open
Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
Cell Adhesion and Migration in the Nervous System
edited by
submission deadline 31 Jan 2026 | Viewed by 137 | Submission Open
Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development; immune system; neurodegeneration
Pain and Therapy: Molecular Perspectives and Future Directions submission deadline 31 Jan 2026 | Viewed by 135 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Molecular Biology)
Sterol Biosynthesis in Organisms
edited by Damjana Rozman and
submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open
Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases
(This special issue belongs to the Section Cellular Biochemistry)
Regulation of Sperm Function and Embryo Development submission deadline 31 Jan 2026 | Viewed by 100 | Submission Open
Keywords: sperm; oocyte; embryo; genes; reproductive technologies
(This special issue belongs to the Section Molecular Reproduction)
Angiogenin: From Molecular Mechanisms to Clinical Implications
edited by
submission deadline 31 Jan 2026 | Viewed by 61 | Submission Open
Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Antioxidant Effects of Bioactive Compounds submission deadline 5 Feb 2026 | 1 articles | Viewed by 2660 | Submission Open
Keywords: bioactive compounds; polyphenols; oxidative stress; chronic diseases; nutraceuticals
Advances in Cold Therapies: Novel Physical Approaches for Musculoskeletal Repair–Molecular Insights
edited by Fackson Mwale
submission deadline 6 Feb 2026 | Viewed by 168 | Submission Open
Keywords: cold therapy; cryotherapy; cryoablation; musculoskeletal repair; inflammation modulation; regenerative medicine; extracellular matrix; cold shock proteins; tissue regeneration; physical therapy
Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration submission deadline 11 Feb 2026 | Viewed by 249 | Submission Open
Keywords: MSC; vesicles; exosomes; tissue repair and regeneration
CD5 and CD6 Immunobiology: Multitask Immunomodulatory Molecules in Infection, Cancer and Autoimmunity
edited by Lozano Francisco and María Velasco-de Andrés
submission deadline 13 Feb 2026 | Viewed by 105 | Submission Open
Keywords: CD5; CD6; T cells; B1a cells; NK cells; immunomodulation; infection; cancer; autoimmunity; immunotherapy
(This special issue belongs to the Section Biological Factors)
Molecular Insights into the Mechanism of Antipsychotic Drugs
edited by Serdar Dursun and
submission deadline 15 Feb 2026 | 2 articles | Viewed by 9841 | Submission Open
Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Advances in Antiviral Drug Development
edited by Angel S. Galabov
submission deadline 15 Feb 2026 | Viewed by 170 | Submission Open
Keywords: viral inhibitors; mechanism of action; antiviral tests
(This special issue belongs to the Section Molecular Medicine)
Advances in Various Roles of High-Density Lipoproteins
edited by
submission deadline 15 Feb 2026 | Viewed by 98 | Submission Open
Keywords: atherosclerosis; high-density lipoprotein (HDL); HDL functions; apolipoproteins; lipid and glucose metabolism
(This special issue belongs to the Section Lipids)
Recent Advances in Immunotherapy for Mesothelioma
edited by Licun Wu
submission deadline 15 Feb 2026 | Viewed by 88 | Submission Open
Keywords: mesothelioma; immunotherapy; tumor microenvironment; biomarkers; tumor heterogeneity
(This special issue belongs to the Section Molecular Medicine)
Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides submission deadline 16 Feb 2026 | 1 articles | Viewed by 485 | Submission Open
Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors
Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism
edited by
submission deadline 20 Feb 2026 | Viewed by 178 | Submission Open
Keywords: host– symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics
Molecular Mechanisms of Traumatic Brain Injury
edited by Xiang Gao
submission deadline 22 Feb 2026 | Viewed by 191 | Submission Open
Keywords: traumatic brain injury; cell death; neural degeneration/regeneration; genetic modification; neuroprotection
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