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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Dysregulation of Calcium Signaling in Pathological Processes

edited by

Antonio Villalobo

submission deadline 30 Nov 2024 | 5 articles | Viewed by 9808 | Submission Open

Keywords: Ca2+-ATPases; calmodulinopathies; cancer; cardiovascular diseases; channelopathies; endocrine diseases; mitochondrial diseases; muscle diseases; neurodegenerative diseases; troponin C

(This special issue belongs to the Section Molecular Medicine)

Brain Sterols: Biosynthesis and Physiology in Health and Disease

edited by

Karoly Mirnics

and

Zeljka Korade

submission deadline 30 Nov 2024 | 4 articles | Viewed by 9567 | Submission Open

Keywords: sterol biosynthesis; sterol turnover; oxysterol; brain; cholesterol; development; aging; medication side effects; inborn errors of sterol biosynthesis; DHCR7

(This special issue belongs to the Section Synthetic Biology and Bioengineering)

Molecular Mechanisms of Alpha-Synuclein in Parkinson's Disease and Other Synucleinopathies

edited by

Felix Javier Jiménez Jiménez

Iván Martínez-Valbuena

and

Diego Santos-García

submission deadline 30 Nov 2024 | 4 articles | Viewed by 9437 | Submission Open

Keywords: alpha-synuclein; molecular mechanisms; movement disorders; Parkinson’ s disease; dementia with lewy bodies; multiple-system atrophy; biomarkers; biochemistry; risk factors

(This special issue belongs to the Section Molecular Medicine)

Recent Developments in Mesenchymal Stem Cells

edited by

Antonietta Rosa Silini

and

Enrico Ragni

submission deadline 30 Nov 2024 | 4 articles | Viewed by 5585 | Submission Open

Keywords: mesenchymal stromal cell; regenerative medicine; secretome

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms of Infectious Pathogen Adaptation, Emergence, and Re-emergence

edited by

Rita Berisio

and

Alessia Ruggiero

submission deadline 30 Nov 2024 | 2 articles | Viewed by 4323 | Submission Open

Keywords: pathogen; structural biology; tuberculosis; function; molecular mechanism

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Life-Extending Biomolecules and Interventions with Medical and Technological Implications

edited by

Shin Murakami

submission deadline 30 Nov 2024 | 1 articles | Viewed by 3864 | Submission Open

Keywords: biomolecules; genes; molecular and metabolic mechanisms; model systems; humans

(This special issue belongs to the Section Molecular Biology)

New Insights into Reactive Oxygen Species in Cell Death and Immunity

edited by

Nades Palaniyar

Marko Radic

and Dhia Azzouz

submission deadline 30 Nov 2024 | 2 articles | Viewed by 3651 | Submission Open

Keywords: reactive oxygen species (ROS); cell death; immune response; ROS-mediated diseases; tools to study ROS

(This special issue belongs to the Section Cellular Biochemistry)

Human Reproductive Biology: Uncertainties and Controversies

edited by

Giuseppe Benagiano

Marwan Habiba

and Paola Bianchi

submission deadline 30 Nov 2024 | 2 articles | Viewed by 2496 | Submission Open

Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization

(This special issue belongs to the Section Molecular Reproduction)

Role of Epigenetics in Organ Fibrosis

edited by

Xingbo Xu

submission deadline 30 Nov 2024 | 1 articles | Viewed by 2365 | Submission Open

Keywords: chronic heart disease; cardiac fibrosis; heart failure; fibroblast; cardiomyocyte; DNA methylation; histone modification; non-coding RNA; gene therapy

(This special issue belongs to the Section Molecular Genetics)

State of the Art and Perspectives in Antimicrobial Peptides

edited by

Annarita Falanga

submission deadline 30 Nov 2024 | 2 articles | Viewed by 2350 | Submission Open

Keywords: antimicrobial peptides; AMPs; chemical modification of AMPs; function; structure; synthesis

(This special issue belongs to the Section Molecular Medicine)

Intracerebral Hemorrhage: Advances in Preclinical Studies: 2nd Edition

edited by

Sangeetha Sukumari-Ramesh

submission deadline 30 Nov 2024 | 2 articles | Viewed by 1680 | Submission Open

Keywords: neuroinflammation; oxidative stress; neurodegeneration; neurological deficits; blood– brain barrier damage

(This special issue belongs to the Section Molecular Medicine)

Biomarkers in Metabolic Diseases, 2nd Edition

edited by

Anna Tylki-Szymańska

and

Patryk Lipiński

submission deadline 30 Nov 2024 | 1 articles | Viewed by 1058 | Submission Open

Keywords: metabolic disorders; inborn errors of metabolism; surrogate biomarkers; biochemical markers; diagnostic markers; newborn screening; molecular analyses; metabolomics; disease progression; treatment efficacy

(This special issue belongs to the Section Molecular Biomarkers)

The Molecular and Pathophysiological Basis of Ectopic Fat Deposition in Non-adipose Tissues

edited by

Gloria Lena Vega

and

Amalia Gastaldelli

submission deadline 30 Nov 2024 | 1 articles | Viewed by 673 | Submission Open

Keywords: metabolic dysfunction-associated hepatosteatosis; myosteatosis; pancreatic steatosis; pancreatic adipocytes; visceral adipose tissue; cardiac steatosis; cardiac adipose tissue; kidney steatosis; macrophage steatosis; perirenal adipose tissue; lipophagy

(This special issue belongs to the Section Molecular Medicine)

Vitamin D in Health and Disease—Honorary Special Issue Commemorating the Work of Dr. Luminita A. Stanciu

edited by

Corina I. Bocsan

and

Gavriela Maria Feketea

submission deadline 30 Nov 2024 | Viewed by 393 | Submission Open

Keywords: vitamin D; immune cells; innate immunity; respiratory diseases; allergy; infections; metabolic disorders; cellular metabolism

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in the Enzymatic Synthesis of Bioactive Compounds

edited by

Bartłomiej Zieniuk

submission deadline 30 Nov 2024 | Viewed by 362 | Submission Open

Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms of Male Infertility

edited by

Mohamed Hammadeh

and

Houda Amor

submission deadline 30 Nov 2024 | Viewed by 320 | Submission Open

Keywords: male infertility; microRNA; NGS; molecular mechanism

(This special issue belongs to the Section Molecular Reproduction)

Melanin-Related Biomolecules: Synthesis, Properties and Applications

edited by Kazumasa Wakamatsu and

Lucia Panzella

submission deadline 30 Nov 2024 | Viewed by 296 | Submission Open

Keywords: melanin; skin aging; hair color; photoaging; antioxidant action; UV protection; cosmetology; display technology; food industry

Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 2nd Edition

edited by

Adriana Georgescu

submission deadline 30 Nov 2024 | Viewed by 292 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Cardiovascular Remodeling

edited by

Mingyi Wang

submission deadline 30 Nov 2024 | Viewed by 290 | Submission Open

Keywords: vascular remodeling aging; extracellular matrix; atherosclerosis peripheral; artery disease; chronic heart failure; cardiovascular associated cognitive decline

(This special issue belongs to the Section Molecular Biology)

Immune Modulation and Atherosclerosis

edited by Xinjie Lu

submission deadline 30 Nov 2024 | Viewed by 286 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; immune modulatory therapy; vaccinations

(This special issue belongs to the Section Molecular Medicine)

Epstein-Barr Virus Disease Mechanisms and Stress Responses: 2nd Edition

edited by

Marshall Vance Williams

submission deadline 30 Nov 2024 | Viewed by 245 | Submission Open

Keywords: Epstein– Barr virus (EBV); reactivation; immune modulation; stress; aging

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Research on Chromosome Abnormalities and Genomic Disorders

edited by

Golder N. Wilson

and Vijay S. Tonk

submission deadline 30 Nov 2024 | Viewed by 234 | Submission Open

Keywords: genomic testing; whole-exome sequencing; microarray analysis; cytogenetics; DNA diagnosis; DNA variation; DNA variant qualification; genetic disease

(This special issue belongs to the Section Molecular Genetics)

Molecular Insights into Sex and Evolution

edited by

Ikuo Miura

and

Michihiko Ito

submission deadline 30 Nov 2024 | Viewed by 205 | Submission Open

Keywords: sex determination; sex chromosome evolution; reproduction; hybridization; speciation; evolution; animals; vertebrates

(This special issue belongs to the Section Molecular Genetics)

Advances in Liver Transplantation and Hepatocellular Carcinoma

edited by

Paolo De Simone

submission deadline 30 Nov 2024 | Viewed by 166 | Submission Open

Keywords: biomolecular markers of liver graft quality; the prediction role of biomolecular markers in liver transplantation; biomolecular markers of graft viability in the setting of machine perfusion technology; biomolecular markers of liver graft dysfunction; HCC biomarkers: AFP; PIVKA; and SPIK; the role of inflammation and immunity; standards of biomolecular HCC diagnosis; biomolecular-based diagnostic algorithms for HCC; biomolecular-based screening and prevention algorithms; advantages and pitfalls of existing biomolecular diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Recent Advances in Anti-tumor Metal Complexes and Drug Delivery Systems: 2nd Edition

edited by Jasmina Dimitrić Marković,

Goran Kaluđerović

and

Dušan Dimić

submission deadline 30 Nov 2024 | Viewed by 151 | Submission Open

Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery

Recent Developments in Biohybrid Systems for Human Pluripotent Stem Cells and Beyond

edited by

Jürgen Hescheler

and

Anna Jezierski

submission deadline 30 Nov 2024 | Viewed by 135 | Submission Open

Keywords: biohybrid systems; cell– material interaction; stem cells

(This special issue belongs to the Section Cellular Biochemistry)

The Immune System and Allergies

edited by

Marco Casciaro

submission deadline 30 Nov 2024 | Viewed by 135 | Submission Open

Keywords: immune system; allergy; inflammation; hypersensitivity; immunology

(This special issue belongs to the Section Cellular Biochemistry)

Protein Interplay in Neurodegeneration, 2nd Edition

edited by

Daniela Valensin

submission deadline 30 Nov 2024 | Viewed by 134 | Submission Open

Keywords: amyloidogenic proteins; metal ions; ROS; protein misfolding; neurons

(This special issue belongs to the Section Biomacromolecules: Proteins)

Obesity, Adipose Tissue and Cardiovascular Diseases: 2nd Edition

edited by

Chiara Macchi

submission deadline 30 Nov 2024 | Viewed by 123 | Submission Open

Keywords: obesity; cardiovascular diseases (CVDs); hypertension; dyslipidemia; atherosclerosis; adipose tissue; adipokines; cytokines

(This special issue belongs to the Section Molecular Biology)

Covalent and Non-covalent Functions of Ubiquitin and Ubiquitin-Like Molecules: Emerging Concepts

edited by Elena Santonico and Dmitris Xirodimas

submission deadline 30 Nov 2024 | Viewed by 116 | Submission Open

Keywords: ubiquitin; ubiquitin-like (UBL); post-translational modification (PTM); protein degradation; E1; E2; E3

Biomolecules and Biomaterials for Tissue Engineering, 2nd Edition

edited by

Shinji Sakai

submission deadline 10 Dec 2024 | Viewed by 151 | Submission Open

Keywords: tissue engineering; bioactive molecules; cellular function; proliferation

(This special issue belongs to the Section Biological and Bio- Materials)

Recent Advances in Histone Deacetylase Research in Health and Disease

edited by

Neal Weintraub

and

Ha Won Kim

submission deadline 15 Dec 2024 | 3 articles | Viewed by 5099 | Submission Open

Keywords: histone deacetylase; HDAC inhibitor; deacetylation; enzymatic and non-enzymatic activity; epigenetics; human disease

(This special issue belongs to the Section Enzymology)

Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network

edited by

Venkatesh Sundararajan

submission deadline 15 Dec 2024 | 1 articles | Viewed by 4226 | Submission Open

Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy

(This special issue belongs to the Section Biomacromolecules: Proteins)

Regulation of Notch Signaling Pathway and Its Relation to Diseases

edited by

Martin Baron

submission deadline 15 Dec 2024 | 2 articles | Viewed by 4008 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Tuberculosis: Immunopathogenesis and Therapeutic Strategies

edited by

Susanna Brighenti

and

Gabriela Godaly

submission deadline 15 Dec 2024 | 2 articles | Viewed by 3294 | Submission Open

Keywords: tuberculosis; drug resistance; granulomatous inflammation; pathogenesis; immune responses; immunomodulation; host-directed therapy; antimicrobial treatment; antimicrobial mechanisms; antimicrobial agents

(This special issue belongs to the Section Molecular Medicine)

Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 15 Dec 2024 | 1 articles | Viewed by 1420 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

Drosophila as a Model System to Study Metabolism

edited by

Justin R. DiAngelo

submission deadline 15 Dec 2024 | 1 articles | Viewed by 1004 | Submission Open

Keywords: carbohydrate; lipid; amino acid; Drosophila; metabolism; insulin; TOR; autophagy; fasting

(This special issue belongs to the Section Molecular Biology)

Human Gut Microbiome and Diet in Health and Diseases: 2nd Edition

edited by

Luis Vitetta

submission deadline 15 Dec 2024 | 1 articles | Viewed by 955 | Submission Open

Keywords: gut microbiome; microbiota; nutrition; functional foods; mucosal immunity; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

Omics Technologies in Precision Medicine: Bridging Disease Research to Clinical Applications

edited by Xiao Chang

submission deadline 15 Dec 2024 | Viewed by 306 | Submission Open

Keywords: genome sequencing; single-cell sequencing; transcriptomics; proteomics; polygenic diseases

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Dec 2024 | Viewed by 278 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

Recent Advances in RNA Editing and Modification

edited by

Toshifumi Tsukahara

submission deadline 15 Dec 2024 | Viewed by 169 | Submission Open

Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation

Molecular Basis and Novel Treatment of Epilepsy

edited by

Fang Zheng

submission deadline 15 Dec 2024 | Viewed by 118 | Submission Open

Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research

(This special issue belongs to the Section Molecular Biology)

New Insights into Essential Genes and Functions

edited by

Marcella Vacca

and

Ilaria Granata

submission deadline 20 Dec 2024 | 2 articles | Viewed by 4300 | Submission Open

Keywords: gene regulation; omics data; essentiality; epigenetics; machine learning

(This special issue belongs to the Section Molecular Genetics)

Tissue Calcification in Normal and Pathological Environments

edited by

Fulvia Ortolani

submission deadline 20 Dec 2024 | 2 articles | Viewed by 4169 | Submission Open

Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death

(This special issue belongs to the Section Molecular Medicine)

State of the Art of Myology in 2024

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 20 Dec 2024 | 2 articles | Viewed by 1267 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Advances in Cellular Biophysics: Transport and Mechanics

edited by Boris Musset and

Peter Pohl

submission deadline 20 Dec 2024 | Viewed by 355 | Submission Open

Keywords: membrane transport; ion transport; cellular biophysics; applied science; basic science

(This special issue belongs to the Section Molecular Biophysics)

Breast Cancer: Molecular Mechanisms and Targeted Therapies

edited by

Sumit Siddharth

submission deadline 20 Dec 2024 | Viewed by 271 | Submission Open

Keywords: breast cancer; breast cancer metastasis; cancer metabolism; molecular and cellular basis of breast cancer; chemoresistance in breast cancer; triple-negative breast cancer and breast cancer stem cell

(This special issue belongs to the Section Molecular Medicine)

Cytoskeleton Structure and Dynamics in Health and Disease

edited by Alla S. Kostyukova and

Pasquale Bianco

submission deadline 20 Dec 2024 | Viewed by 200 | Submission Open

Keywords: actin; myosin; cytoskeleton; membrane-cytoskeleton associations; mechanotransduction; cytokinesis; nuclear cytoskeleton; contractile systems; cell motility; cell morphogenesis; cell adhesions; signal transduction; cytoskeleton structure and dynamics; microtubules; actin filaments; intermediate filaments organization

(This special issue belongs to the Section Biomacromolecules: Proteins)

Novel Insights of Endocrinology and Obesity

edited by Orien L. Tulp

submission deadline 20 Dec 2024 | Viewed by 125 | Submission Open

Keywords: obesity; overweight; metabolic syndrome (MetS); NIDDM; public health

(This special issue belongs to the Section Molecular Biology)

Peroxisome Proliferator-Activated Receptors (PPARs): A Themed Issue in Honor of Prof. Walter Wahli

edited by Hervé Guillou and

Manuel Vázquez-Carrera

submission deadline 30 Dec 2024 | 7 articles | Viewed by 6565 | Submission Open

Keywords: PPAR; nuclear receptors; metabolism; cancer; inflammation; pharmacology; toxicology

(This special issue belongs to the Section Enzymology)

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