Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Diseases: From Molecular Mechanisms to Therapy Strategies submission deadline 31 Jan 2026 | Viewed by 257 | Submission Open
Keywords: inborn errors of metabolism; molecular mechanisms; gene identification; therapeutic; approaches; translation
Molecular Biology and Therapy of Breast Cancer
edited by
submission deadline 31 Jan 2026 | Viewed by 221 | Submission Open
Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA
Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease submission deadline 31 Jan 2026 | Viewed by 208 | Submission Open
Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation
(This special issue belongs to the Section Molecular Biology)
Nucleic Acid-Lipid Interactions: Bridging Molecular Insights with Therapeutic Applications
edited by Weiwei He and Serdal Kirmizialtin
submission deadline 31 Jan 2026 | Viewed by 205 | Submission Open
Keywords: nucleic acids; lipid membranes; interactions; structural transitions; physical mechanism
Endometriosis: Molecular Pathogenesis and Translational Implications
edited by
submission deadline 31 Jan 2026 | Viewed by 163 | Submission Open
Keywords: endometriosis; pathogenesis; adenomyosis; diagnosis; detection
(This special issue belongs to the Section Molecular Medicine)
Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders
edited by
submission deadline 31 Jan 2026 | Viewed by 153 | Submission Open
Keywords: neurodevelopmental disorders; epigenetics; gene– environment interaction; chromatin remodeling; neurogenomics
(This special issue belongs to the Section Molecular Genetics)
Mechanisms in Stress-Related Disorders, Anxiety and Fear
edited by Veronica Begni
submission deadline 31 Jan 2026 | Viewed by 147 | Submission Open
Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
Cell Adhesion and Migration in the Nervous System
edited by
submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development; immune system; neurodegeneration
Pain and Therapy: Molecular Perspectives and Future Directions submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Molecular Biology)
Sterol Biosynthesis in Organisms
edited by Damjana Rozman and
submission deadline 31 Jan 2026 | Viewed by 109 | Submission Open
Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases
(This special issue belongs to the Section Cellular Biochemistry)
Regulation of Sperm Function and Embryo Development submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open
Keywords: sperm; oocyte; embryo; genes; reproductive technologies
(This special issue belongs to the Section Molecular Reproduction)
Angiogenin: From Molecular Mechanisms to Clinical Implications
edited by
submission deadline 31 Jan 2026 | Viewed by 53 | Submission Open
Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Antioxidant Effects of Bioactive Compounds submission deadline 5 Feb 2026 | 1 articles | Viewed by 2487 | Submission Open
Keywords: bioactive compounds; polyphenols; oxidative stress; chronic diseases; nutraceuticals
Advances in Cold Therapies: Novel Physical Approaches for Musculoskeletal Repair–Molecular Insights
edited by Fackson Mwale
submission deadline 6 Feb 2026 | Viewed by 165 | Submission Open
Keywords: cold therapy; cryotherapy; cryoablation; musculoskeletal repair; inflammation modulation; regenerative medicine; extracellular matrix; cold shock proteins; tissue regeneration; physical therapy
Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration submission deadline 11 Feb 2026 | Viewed by 242 | Submission Open
Keywords: MSC; vesicles; exosomes; tissue repair and regeneration
CD5 and CD6 Immunobiology: Multitask Immunomodulatory Molecules in Infection, Cancer and Autoimmunity
edited by Lozano Francisco and María Velasco-de Andrés
submission deadline 13 Feb 2026 | Viewed by 103 | Submission Open
Keywords: CD5; CD6; T cells; B1a cells; NK cells; immunomodulation; infection; cancer; autoimmunity; immunotherapy
(This special issue belongs to the Section Biological Factors)
Molecular Insights into the Mechanism of Antipsychotic Drugs
edited by Serdar Dursun and
submission deadline 15 Feb 2026 | 2 articles | Viewed by 9735 | Submission Open
Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Advances in Antiviral Drug Development
edited by Angel S. Galabov
submission deadline 15 Feb 2026 | Viewed by 168 | Submission Open
Keywords: viral inhibitors; mechanism of action; antiviral tests
(This special issue belongs to the Section Molecular Medicine)
Advances in Various Roles of High-Density Lipoproteins
edited by
submission deadline 15 Feb 2026 | Viewed by 91 | Submission Open
Keywords: atherosclerosis; high-density lipoprotein (HDL); HDL functions; apolipoproteins; lipid and glucose metabolism
(This special issue belongs to the Section Lipids)
Recent Advances in Immunotherapy for Mesothelioma
edited by Licun Wu
submission deadline 15 Feb 2026 | Viewed by 83 | Submission Open
Keywords: mesothelioma; immunotherapy; tumor microenvironment; biomarkers; tumor heterogeneity
(This special issue belongs to the Section Molecular Medicine)
Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides submission deadline 16 Feb 2026 | Viewed by 169 | Submission Open
Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors
Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism
edited by
submission deadline 20 Feb 2026 | Viewed by 172 | Submission Open
Keywords: host– symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics
Molecular Mechanisms of Traumatic Brain Injury
edited by Xiang Gao
submission deadline 22 Feb 2026 | Viewed by 186 | Submission Open
Keywords: traumatic brain injury; cell death; neural degeneration/regeneration; genetic modification; neuroprotection
Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies submission deadline 25 Feb 2026 | Viewed by 124 | Submission Open
Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis
(This special issue belongs to the Section Biological Factors)
Role of Oxidative Stress in Vascular Diseases submission deadline 26 Feb 2026 | Viewed by 176 | Submission Open
Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk
Extracellular Vesicles as Natural Nanocarriers: Advances in Cancer, Tissue Regeneration and Skin Health
edited by
submission deadline 26 Feb 2026 | Viewed by 146 | Submission Open
Keywords: extracellular vesicles; natural nanocarriers; drug delivery; cancer therapy; regenerative medicine; skin health; dermocosmetics; tumor microenvironment; bioactive cargo; targeted delivery
Molecular Advances in Wound Healing and Skin Regeneration
edited by and Muhammad Shafiq
submission deadline 28 Feb 2026 | 2 articles | Viewed by 28256 | Submission Open
Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair
(This special issue belongs to the Section Biological Factors)
Design and Synthesis of Bioactive Compounds for Therapeutic Applications submission deadline 28 Feb 2026 | 11 articles | Viewed by 26087 | Submission Open
Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies submission deadline 28 Feb 2026 | 9 articles | Viewed by 16696 | Submission Open
Keywords: chronic heart failure; pathophysiology; comorbidities; new therapies; molecular pathways
(This special issue belongs to the Section Molecular Medicine)
Cannabinoids in Neurobehavioral Modulation submission deadline 28 Feb 2026 | 4 articles | Viewed by 16125 | Submission Open
Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational
(This special issue belongs to the Section Molecular Biology)
Inflammatory Mechanisms and Molecular Targets in Neurological Disorders: Effects of Neuroprotective Drugs submission deadline 28 Feb 2026 | 4 articles | Viewed by 11675 | Submission Open
Keywords: neuroinflammation; neurological disorders; molecular targets; therapeutic strategies; neuroimmunology
(This special issue belongs to the Section Molecular Medicine)
Immune Responses in Type 1 Diabetes
edited by and Sally C. Kent
submission deadline 28 Feb 2026 | 5 articles | Viewed by 11326 | Submission Open
Keywords: type 1 diabetes; insulitis; immune response
(This special issue belongs to the Section Molecular Biology)
Innovative Biomolecular Structure Analysis Techniques
edited by Tzanko I. Doukov
submission deadline 28 Feb 2026 | 6 articles | Viewed by 10394 | Submission Open
Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Novel Molecules for Cancer Treatment (3rd Edition) submission deadline 28 Feb 2026 | 5 articles | Viewed by 9009 | Submission Open
Keywords: cancer; small molecules; antibody-drug-conjugated; tyrosine kinase inhibitors; target therapy; monoclonal antibodies; immunotherapy; natural compounds
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular and Cellular Mechanisms in Anti-Thrombosis submission deadline 28 Feb 2026 | 3 articles | Viewed by 7487 | Submission Open
Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms
(This special issue belongs to the Section Molecular Medicine)
Biomarkers and Molecular Basis of Psychiatry
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 7246 | Submission Open
Keywords: mental health; bipolar disorders; mood; anxiety; psychosis; schizophrenia; biomarkers
(This special issue belongs to the Section Biological Factors)
Structural Biology of Protein
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 7229 | Submission Open
Keywords: structural characterization; protein structure– function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein– protein interactions
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Signalling Pathways in Tumorigenesis and Tumor Suppression
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 6300 | Submission Open
Keywords: E2F; RB; p53; cancer; tumor suppression
(This special issue belongs to the Section Biological Factors)
Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 5849 | Submission Open
Keywords: laboratory genetics and genomics; genetic and genomic biomarkers; diagnostic; prognostic; predictive; companion diagnosis; targeted therapy; nucleic acid
(This special issue belongs to the Section Molecular Biomarkers)
New Insights into Forensic Molecular Genetics
edited by
submission deadline 28 Feb 2026 | 2 articles | Viewed by 5700 | Submission Open
Keywords: forensic; DNA; RNA; protein; mtDNA; epigenetics; microbiome
(This special issue belongs to the Section Molecular Genetics)
Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation
edited by Guanglin Zhang and
submission deadline 28 Feb 2026 | 4 articles | Viewed by 5517 | Submission Open
Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut– brain axis; cognitive rehabilitation
(This special issue belongs to the Section Molecular Biology)
Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action
edited by Chandra Mishra and
submission deadline 28 Feb 2026 | 2 articles | Viewed by 4642 | Submission Open
Keywords: heterocyclic compounds; anticancer; synthetic; natural
(This special issue belongs to the Section Molecular Medicine)
Glutamate and Glutamate Receptors in Health and Diseases, Second Edition submission deadline 28 Feb 2026 | 3 articles | Viewed by 4260 | Submission Open
Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration
(This special issue belongs to the Section Molecular Biology)
Polyphosphate (PolyP) in Health and Disease
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 3156 | Submission Open
Keywords: polyphosphate; polyP; biomarker and therapeutic target
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Biomarkers in Metabolic Diseases, 2nd Edition submission deadline 28 Feb 2026 | 1 articles | Viewed by 2987 | Submission Open
Keywords: metabolic disorders; inborn errors of metabolism; surrogate biomarkers; biochemical markers; diagnostic markers; newborn screening; molecular analyses; metabolomics; disease progression; treatment efficacy
(This special issue belongs to the Section Molecular Biomarkers)
Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition
edited by , Alessandra Andrisani and Chiara Sabbadin
submission deadline 28 Feb 2026 | 2 articles | Viewed by 2856 | Submission Open
Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system
(This special issue belongs to the Section Molecular Biology)
Tumor Genomics and Liquid Biopsy in Cancer Biology
edited by
submission deadline 28 Feb 2026 | 2 articles | Viewed by 2750 | Submission Open
Keywords: circulating tumor DNA (ctDNA); circulating tumor cells (CTCs); exosomes and extracellular vesicles; circulating free RNAs and microRNAs; tumor heterogeneity; mechanisms of metastasis; tumor clonal evolution; drug resistance; tumor microenvironment; multi-omics integration
(This special issue belongs to the Section Molecular Biology)
Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 2717 | Submission Open
Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Mechanism and Detection of SARS-CoV-2
edited by
submission deadline 28 Feb 2026 | 2 articles | Viewed by 2607 | Submission Open
Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection
(This special issue belongs to the Section Molecular Biology)
Single-Molecule Protein Electronics
edited by and Bintian Zhang
submission deadline 28 Feb 2026 | 2 articles | Viewed by 2333 | Submission Open
Keywords: protein electronics; molecular electronics; single-molecule conductance; protein detection; protein sensing; label-free detection; conductance gating in proteins; electron transport mechanisms in proteins; coherence and dephasing in proteins; role of water in protein conductance; extended electronic states in proteins; hopping conductance in proteins; long-range hopping in proteins; electrode– protein interfaces; charge injection barriers at protein– electrode interfaces; proteins as electronic devices; protein assemblies as electronic devices; DNA electronics; electron transport in DNA; DNA– electrode interfaces; charge injection at a DNA– electrode interface; barrier to charge injection at a DNA– electrode interface
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
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