Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Kidney Disease Development and Therapy Strategies submission deadline 31 Jan 2026 | 7 articles | Viewed by 19344 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
The Immune System and Allergies
edited by
submission deadline 31 Jan 2026 | 4 articles | Viewed by 14142 | Submission Open
Keywords: immune system; allergy; inflammation; hypersensitivity; immunology
(This special issue belongs to the Section Cellular Biochemistry)
Cellular and Molecular Mechanisms in Cardiopathy and Therapeutic Strategies
edited by Ying-Hsi Lin and Shengjie Lu
submission deadline 31 Jan 2026 | 8 articles | Viewed by 12120 | Submission Open
Keywords: heart failure; cardiac remodelling; contractile dysfunction; bioenergetics; gene replacement or editing
(This special issue belongs to the Section Molecular Medicine)
Digestive Enzymes in Health and Disease
edited by Stefan G. Pierzynowski, Kateryna Pierzynowska, and
submission deadline 31 Jan 2026 | 6 articles | Viewed by 11689 | Submission Open
Keywords: digestive enzymes; gastrointestinal health; enzyme replacement therapy; gut microbiome; metabolic disorders; enzyme regulation; disease biomarkers; inflammatory diseases; nutrient absorption; therapeutic enzymes
(This special issue belongs to the Section Enzymology)
Advances in Metabolites Produced by Microbiota submission deadline 31 Jan 2026 | 3 articles | Viewed by 11112 | Submission Open
Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors
edited by and Jason M. Conley
submission deadline 31 Jan 2026 | 4 articles | Viewed by 10884 | Submission Open
Keywords: diabetes; obesity; metabolism; GPCR; signaling
(This special issue belongs to the Section Molecular Biology)
Advanced Biomaterials for Healing Oral Tissues
edited by Miki Taketomi Saito and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 8671 | Submission Open
Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing
(This special issue belongs to the Section Bio-Engineered Materials)
The Illumination of Biophysical Mechanisms by Hydrogen Exchange: A Themed Issue in Honor of Professor S. Walter Englander
edited by
submission deadline 31 Jan 2026 | 4 articles | Viewed by 8668 | Submission Open
Keywords: hydrogen exchange chemistry; HX– NMR; HX-MS; protein folding; allostery; protein binding; protein thermodynamics; protein biophysics; protein function
(This special issue belongs to the Section Molecular Biology)
Retinal Diseases: Molecular Mechanisms and Therapies
edited by and Raquel Boia
submission deadline 31 Jan 2026 | 3 articles | Viewed by 8509 | Submission Open
Keywords: retinal diseases; molecular mechanisms; therapeutic strategies; vision impairment; gene therapy; retinal degeneration; neuroprotection; innovative treatments
(This special issue belongs to the Section Cellular Biochemistry)
Pharmacology of Cardiovascular Diseases
edited by , Alexandra Gyongyosi and
submission deadline 31 Jan 2026 | 3 articles | Viewed by 7966 | Submission Open
Keywords: cardioprotection autophagy; redox balance; heart faliure; cardiovascular pharmacotherapy
(This special issue belongs to the Section Molecular Medicine)
Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders
edited by and Salvatore Fioriniello
submission deadline 31 Jan 2026 | 2 articles | Viewed by 5219 | Submission Open
Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic; prognostic and therapeutic approaches for chromatin disorders
(This special issue belongs to the Section Molecular Medicine)
Neurodevelopmental Disorders: Genetic Studies and Therapeutic Strategies
edited by and Bruno Bontempi
submission deadline 31 Jan 2026 | 2 articles | Viewed by 5026 | Submission Open
Keywords: mouse models; Autism Spectrum disorder; transgenic rodents; pharmacological treatments; gene-environment interactions; neurodevelopmental disorders; rare diseases
(This special issue belongs to the Section Molecular Genetics)
Molecular Mechanisms and Novel Treatments of Stroke
edited by and Naseem Akhter
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4270 | Submission Open
Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches
(This special issue belongs to the Section Molecular Biology)
Advances and Novel Strategies for Studying Underexplored Post-Translational Modifications (PTMs)
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4241 | Submission Open
Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging
(This special issue belongs to the Section Molecular Biology)
New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition
edited by , and Tarun W. Dasari
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4222 | Submission Open
Keywords: brain– heart axis; heart and stroke; stress-induced cardiomyopathy; cardiovascular disease
(This special issue belongs to the Section Molecular Medicine)
Pluripotent Stem Cells: From Basic Research to Therapeutic Applications submission deadline 31 Jan 2026 | 1 articles | Viewed by 3712 | Submission Open
Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications
(This special issue belongs to the Section Molecular Biology)
Natural Products and Their Derivatives with Antiviral Activity
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 3462 | Submission Open
Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Key Molecules Regulating Plant Response to Abiotic Stress: Transcription Factors and Stress-Induced Proteins
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2334 | Submission Open
Keywords: abiotic stress response; transcription factors; stress-induced proteins; molecular mechanisms; transcriptomics; omics; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Current Advances of Metal Complexes for Biomedical Applications submission deadline 31 Jan 2026 | 1 articles | Viewed by 2218 | Submission Open
Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications
(This special issue belongs to the Section Chemical Biology)
Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1950 | Submission Open
Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems
(This special issue belongs to the Section Cellular Biochemistry)
State-of-the-Art Protein X-Ray Crystallography
edited by Wu-Pei Su and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1592 | Submission Open
Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Pathogenesis and Targeted Therapy of Neurodegenerative Diseases submission deadline 31 Jan 2026 | 1 articles | Viewed by 1579 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments
(This special issue belongs to the Section Molecular Medicine)
Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders
edited by and Anita Racetin
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1504 | Submission Open
Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets
(This special issue belongs to the Section Molecular Medicine)
Lung Disease: From Molecular Mechanism to Therapeutic Opportunities
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1358 | Submission Open
Keywords: biomarkers; pharmacotherapeutics; cell signaling; innate immunity; inflammation
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Basis of Parasite Infection submission deadline 31 Jan 2026 | 1 articles | Viewed by 1172 | Submission Open
Keywords: parasite infection; host– parasite interaction; cellular invasion; molecular mechanisms; immune evasion
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer
edited by Panneerdoss Subbarayalu
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1065 | Submission Open
Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis
(This special issue belongs to the Section Molecular Medicine)
Synthesis, Characterization and Validation of Small Molecule Compounds
edited by Mohamed Fares Metwaly
submission deadline 31 Jan 2026 | 1 articles | Viewed by 910 | Submission Open
Keywords: medicinal chemistry; structure-based drug design; enzyme inhibitors; multi-target therapeutics
(This special issue belongs to the Section Molecular Biology)
Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms submission deadline 31 Jan 2026 | 1 articles | Viewed by 802 | Submission Open
Keywords: alcohol; ethanol metabolism; ethanol– protein interactions; ethanol– membrane interactions; cardiovascular health and disease
(This special issue belongs to the Section Molecular Medicine)
New Insights into Mesothelial Cells
edited by Francesca Bodega and Cristina Porta
submission deadline 31 Jan 2026 | 1 articles | Viewed by 573 | Submission Open
Keywords: mesothelial cells; serous cavities; lubricating fluids; epithelial– mesenchymal transition; fibrosis; tissue repair; mesothelioma; tumor microenvironment; immune response
(This special issue belongs to the Section Molecular Biology)
Inflammation Biology in Orthodontic Tooth Movement
edited by
submission deadline 31 Jan 2026 | Viewed by 410 | Submission Open
Keywords: orthodontic tooth movement; inflammation; cytokine; root resorption; accelerated orthodontic tooth movement; relapse
(This special issue belongs to the Section Biological Factors)
Mechanisms of Gene Regulation in Embryos
edited by and Adam Davis
submission deadline 31 Jan 2026 | Viewed by 356 | Submission Open
Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Therapy Targeting DNA Damage and Repair Systems
edited by , and Anahita Mojiri
submission deadline 31 Jan 2026 | Viewed by 341 | Submission Open
Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis
(This special issue belongs to the Section Biological Factors)
The Role of Extracellular Vesicles in Drug Delivery
edited by
submission deadline 31 Jan 2026 | Viewed by 316 | Submission Open
Keywords: extracellular vesicles; drug delivery systems; extracellular vesicle engineering; cancer treatment; gene therapy
(This special issue belongs to the Section Molecular Biology)
Focus on Perineural Invasion in Pancreatic Cancer
edited by
submission deadline 31 Jan 2026 | Viewed by 307 | Submission Open
Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins
(This special issue belongs to the Section Molecular Medicine)
Genomics and Molecular Biology of Solid Tumors
edited by Dragoş Creţoiu and Silviu Cristian Voinea
submission deadline 31 Jan 2026 | Viewed by 303 | Submission Open
Keywords: solid tumors; tumor microenvironment; genomic instability; cancer stem cells; liquid biopsy
(This special issue belongs to the Section Molecular Biology)
Metabolic Diseases: From Molecular Mechanisms to Therapy Strategies submission deadline 31 Jan 2026 | Viewed by 260 | Submission Open
Keywords: inborn errors of metabolism; molecular mechanisms; gene identification; therapeutic; approaches; translation
Molecular Biology and Therapy of Breast Cancer
edited by
submission deadline 31 Jan 2026 | Viewed by 224 | Submission Open
Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA
Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease submission deadline 31 Jan 2026 | Viewed by 211 | Submission Open
Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation
(This special issue belongs to the Section Molecular Biology)
Nucleic Acid-Lipid Interactions: Bridging Molecular Insights with Therapeutic Applications
edited by Weiwei He and Serdal Kirmizialtin
submission deadline 31 Jan 2026 | Viewed by 210 | Submission Open
Keywords: nucleic acids; lipid membranes; interactions; structural transitions; physical mechanism
Endometriosis: Molecular Pathogenesis and Translational Implications
edited by
submission deadline 31 Jan 2026 | Viewed by 170 | Submission Open
Keywords: endometriosis; pathogenesis; adenomyosis; diagnosis; detection
(This special issue belongs to the Section Molecular Medicine)
Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders
edited by
submission deadline 31 Jan 2026 | Viewed by 156 | Submission Open
Keywords: neurodevelopmental disorders; epigenetics; gene– environment interaction; chromatin remodeling; neurogenomics
(This special issue belongs to the Section Molecular Genetics)
Mechanisms in Stress-Related Disorders, Anxiety and Fear
edited by Veronica Begni
submission deadline 31 Jan 2026 | Viewed by 151 | Submission Open
Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
Cell Adhesion and Migration in the Nervous System
edited by
submission deadline 31 Jan 2026 | Viewed by 131 | Submission Open
Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development; immune system; neurodegeneration
Pain and Therapy: Molecular Perspectives and Future Directions submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Molecular Biology)
Sterol Biosynthesis in Organisms
edited by Damjana Rozman and
submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open
Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases
(This special issue belongs to the Section Cellular Biochemistry)
Regulation of Sperm Function and Embryo Development submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open
Keywords: sperm; oocyte; embryo; genes; reproductive technologies
(This special issue belongs to the Section Molecular Reproduction)
Angiogenin: From Molecular Mechanisms to Clinical Implications
edited by
submission deadline 31 Jan 2026 | Viewed by 57 | Submission Open
Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Antioxidant Effects of Bioactive Compounds submission deadline 5 Feb 2026 | 1 articles | Viewed by 2571 | Submission Open
Keywords: bioactive compounds; polyphenols; oxidative stress; chronic diseases; nutraceuticals
Advances in Cold Therapies: Novel Physical Approaches for Musculoskeletal Repair–Molecular Insights
edited by Fackson Mwale
submission deadline 6 Feb 2026 | Viewed by 167 | Submission Open
Keywords: cold therapy; cryotherapy; cryoablation; musculoskeletal repair; inflammation modulation; regenerative medicine; extracellular matrix; cold shock proteins; tissue regeneration; physical therapy
Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration submission deadline 11 Feb 2026 | Viewed by 246 | Submission Open
Keywords: MSC; vesicles; exosomes; tissue repair and regeneration
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