Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs
edited by
submission deadline 19 Jun 2026 | 2 articles | Viewed by 1607 | Submission Open
Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs
Advances in p53 Research submission deadline 20 Jun 2026 | 3 articles | Viewed by 14757 | Submission Open
Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)
(This special issue belongs to the Section Molecular Biology)
Molecular Biomarkers of Epileptogenesis
edited by Pedro J. Serrano-Castro
submission deadline 20 Jun 2026 | 4 articles | Viewed by 12950 | Submission Open
Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology
(This special issue belongs to the Section Molecular Biomarkers)
Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition
edited by and Naoko Tsugawa
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1360 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450
(This special issue belongs to the Section Chemical Biology)
Oral Cancer: New Advances in Therapies
edited by , and Nicola Cirillo
submission deadline 20 Jun 2026 | Viewed by 67 | Submission Open
Keywords: oral cancer; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; radiotherapy; chemotherapy; gene therapy; precision medicine; translational research
(This special issue belongs to the Section Molecular Medicine)
South American Native Species as Sources of Bioactive Compounds: Opportunities and Challenges
edited by Andressa Mara Baseggio and Maurício Ariel Rostagno
submission deadline 20 Jun 2026 | Viewed by 61 | Submission Open
Keywords: South American biodiversity; bioactive compounds; chemical characterization; health properties
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Structure and Function of MHC Class I Molecules in Health and Disease: Implications in Aging and Neuro-Immune Crosstalk submission deadline 20 Jun 2026 | Viewed by 55 | Submission Open
Keywords: classical MHC-I molecules; human leukocyte antigen (HLA) class I; soluble HLA class I; immunological and non-immunological functions; neuro-immune crosstalk; aging and brain cognition
(This special issue belongs to the Section Cellular Biochemistry)
Novel Signaling Pathways in Cardiometabolic Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 38 | Submission Open
Keywords: metabolic disorder; hypertension; stroke; cardiovascular disease; molecular mechanisms; hypertrophy; fibrosis; lipotoxiocity; mitochondrial function; inflammation
(This special issue belongs to the Section Biological Factors)
Molecular Mechanisms and Therapeutic Potential of Extracellular Vesicles in Neurovascular Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 33 | Submission Open
Keywords: extracellular vesicles; neurovascular diseases; cellular communications; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 32 | Submission Open
Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy
(This special issue belongs to the Section Cellular Biochemistry)
WDFY1 in Immune Regulation and Disease: From Molecular Mechanisms to Therapeutic Applications
edited by Wenhai Shao
submission deadline 20 Jun 2026 | Viewed by 28 | Submission Open
Keywords: WDFY1; membrane tracking; TLR3; TLR4; autophagy; ubiquitination; lupus
(This special issue belongs to the Section Molecular Medicine)
The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 25 Jun 2026 | 3 articles | Viewed by 10265 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
(This special issue belongs to the Section Chemical Biology)
Pulmonary Fibrosis: From Molecular Mechanism to Therapeutic Targets
edited by Santosh Yadav, Muralidharan Anbalagan and Renat Shaykhiev
submission deadline 25 Jun 2026 | Viewed by 81 | Submission Open
Keywords: idiopathic pulmonary fibrosis; DNA damage response; senescence; immune checkpoint inhibitors
(This special issue belongs to the Section Molecular Medicine)
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 26 Jun 2026 | 1 articles | Viewed by 795 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions
edited by Yurong Xie and Hongbin Wei
submission deadline 26 Jun 2026 | 2 articles | Viewed by 648 | Submission Open
Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding
(This special issue belongs to the Section Molecular Genetics)
Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases
edited by , and Arun Raja
submission deadline 26 Jun 2026 | Viewed by 172 | Submission Open
Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology
(This special issue belongs to the Section Chemical Biology)
Spotlight on Hot Cancer Biological Biomarkers submission deadline 30 Jun 2026 | 4 articles | Viewed by 8504 | Submission Open
Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology
(This special issue belongs to the Section Molecular Biomarkers)
Mechanisms of Kidney Injury and Treatment Modalities
edited by Utpal Sen
submission deadline 30 Jun 2026 | 2 articles | Viewed by 6982 | Submission Open
Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration
(This special issue belongs to the Section Molecular Biology)
New Insights into Protein Aggregation in Condensed and Amyloid States submission deadline 30 Jun 2026 | 2 articles | Viewed by 3918 | Submission Open
Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 3447 | Submission Open
Keywords: pulmonary diseases; diagnostics; therapeutics
(This special issue belongs to the Section Molecular Medicine)
The Biomarkers in Renal Diseases
edited by and María Carmen Ruiz Fuentes
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3199 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
Advances in Pharmacognosy and Phytochemistry: From Molecular to Pre-Clinical Insights submission deadline 30 Jun 2026 | 1 articles | Viewed by 2901 | Submission Open
Keywords: metabolomics; drug discovery; phytopharmacology; medicinal plants
(This special issue belongs to the Section Natural and Bio-derived Molecules)
New Insights into Stem Cell-Derived Exosomes in Human Health and Disease
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2739 | Submission Open
Keywords: stem cells; exosomes; regenerative medicine; diagnostics
(This special issue belongs to the Section Cellular Biochemistry)
Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases
edited by Aurora Daniele and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2526 | Submission Open
Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease
(This special issue belongs to the Section Biological Factors)
Molecular Basis and Novel Treatment of Epilepsy
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2447 | Submission Open
Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research
(This special issue belongs to the Section Molecular Biology)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Jun 2026 | 2 articles | Viewed by 2184 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Mitochondria as a Target for Tissue Repair and Regeneration
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1536 | Submission Open
Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy
(This special issue belongs to the Section Molecular Biology)
Lipid Signaling in Human Disease
edited by Berit Johansen and Felicity Ashcroft
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1258 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals
edited by and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1127 | Submission Open
Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry
(This special issue belongs to the Section Chemical Biology)
Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials
edited by Caterina Ricci and
submission deadline 30 Jun 2026 | Viewed by 226 | Submission Open
Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 30 Jun 2026 | Viewed by 197 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
Bacterial Molecular Biology: Stress Responses and Adaptation
edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa
submission deadline 30 Jun 2026 | Viewed by 158 | Submission Open
Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks
(This special issue belongs to the Section Molecular Biology)
Exercise Immunology: Molecular Mechanisms and Health Applications
edited by , , Michał Sławiński and
submission deadline 30 Jun 2026 | Viewed by 143 | Submission Open
Keywords: post-effort immune response; lifestyle-associated molecular patterns; damage-associated molecular patterns; immune cell; cell signaling; cell death; growth factor; chemokines; cytokines; transcription factors
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 3rd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 116 | Submission Open
Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease
Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in the Regenerative Medicine of Musculoskeletal System submission deadline 30 Jun 2026 | Viewed by 104 | Submission Open
Keywords: mesenchymal stem/stromal cells; extracellular vesicles  ; musculoskeletal regeneration  ; immunomodulation  ; anabolism  ; cell therapy  ; cell-free therapy  ; secretome
Non-Invasive Biomarker Screening in Cancer
edited by and F. G. Pinto
submission deadline 30 Jun 2026 | Viewed by 99 | Submission Open
Keywords: non-invasive biomarkers; cancer screening; metabolomics; lipidomics; proteomics; liquid biopsy; early detection; multiomics; precision oncology; diagnostic technologies
(This special issue belongs to the Section Molecular Biomarkers)
Novel Biomarkers in Breast Cancer: Leveraging Multi-Omics and AI for Discovery and Validation
edited by Konstantinos Venetis, and Marianna D'Ercole
submission deadline 30 Jun 2026 | Viewed by 93 | Submission Open
Keywords: breast cancer; biomarkers; liquid biopsy; multi-omics; digital pathology
(This special issue belongs to the Section Molecular Biomarkers)
Molecular and Physiological Regulation of Biomechanical Signalling
edited by
submission deadline 30 Jun 2026 | Viewed by 89 | Submission Open
Keywords: biomechanics; molecular signalling; mechanosensitive ion channels; Piezo1& 2; microfluidics
Forces Driving Macromolecular Recognition: Role in Drug Design and Discovery
edited by David P. Remeta and
submission deadline 30 Jun 2026 | Viewed by 84 | Submission Open
Keywords: macromolecular recognition; drug design and discovery; biomolecular structure and dynamics; computational modeling; ligand– receptor binding energetics; drug-target interactions; thermodynamic forces; protein-ligand binding; drug discovery and optimization; protein-nucleic acid interactions; intrinsically disordered proteins; protein aggregation and disease
(This special issue belongs to the Section Chemical Biology)
Novel Insights into Epithelial Mesenchymal Transition (EMT) in Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 78 | Submission Open
Keywords: EMT; epithelial– mesenchymal plasticity; hybrid E/M states; single-cell; spatial transcriptomics/proteomics; multiplex IHC/IF; RNA in situ; CTCs; ctDNA; radiomics; computational pathology; immune evasion; therapy resistance; metastasis; biomarkers; reporting standards; reproducibility; clinical translation
(This special issue belongs to the Section Molecular Medicine)
Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application submission deadline 30 Jun 2026 | Viewed by 68 | Submission Open
Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders
(This special issue belongs to the Section Biological Factors)
Enolase: Molecular Functions and Pathological Roles in Health and Disease
edited by
submission deadline 30 Jun 2026 | Viewed by 64 | Submission Open
Keywords: enolase; enzyme regulation; cancer metabolism; neurodegeneration; autoimmune disease; biomarkers; inflammation; therapeutic targets
(This special issue belongs to the Section Cellular Biochemistry)
Plant Secondary Metabolism Engineering and Bioactive Compounds submission deadline 30 Jun 2026 | Viewed by 59 | Submission Open
Keywords: bioactive compounds; elicitation; plant metabolism; fenetic transformation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Advances in Protein–Ligand Interactions: From Structure, Function to Applications, 2nd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 58 | Submission Open
Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes
(This special issue belongs to the Section Chemical Biology)
Multifunctional Nanocarriers for Advanced Therapy and Diagnosis
edited by
submission deadline 30 Jun 2026 | Viewed by 56 | Submission Open
Keywords: nanocarriers; targeted drug delivery; stimuli-responsive nanoparticles; biological barriers; smart delivery systems; nanotheranostics; functionalized nanoparticles
(This special issue belongs to the Section Bio-Engineered Materials)
Molecular Mechanism of Viral Infection and Host Immunity in Transplantation
edited by Eva Mischak Weissinger
submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open
Keywords: allogeneic stem cell/or solid organ transplantation; immunosuppressed host; immune reconstitution; virus reactive/specific cytotoxic T-/NK-cells; immune reconstitution post-transplantation
(This special issue belongs to the Section Molecular Medicine)
Nanomaterials and Their Applications in Biomedicine—2nd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 46 | Submission Open
Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration
(This special issue belongs to the Section Bio-Engineered Materials)
Second Messenger Systems in Cellular Communication and Disease
edited by
submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets
(This special issue belongs to the Section Molecular Biology)
Adipose-Derived Stem Cells: 3D Culture Systems and Biological Insights
edited by Anna Barbara Di Stefano
submission deadline 30 Jun 2026 | Viewed by 30 | Submission Open
Keywords: stem cell biology; cancer stem cells; mesenchymal stem cells; induced pluripotent stem cells; 3D cultures; cell-based therapies
(This special issue belongs to the Section Cellular Biochemistry)
The Role of Calcium Signaling in Cardiac and Skeletal Muscle submission deadline 15 Jul 2026 | 3 articles | Viewed by 4190 | Submission Open
Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation
(This special issue belongs to the Section Molecular Biology)
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