Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches—2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 1062
Editor
Interests: heart failure; cardiovascular system; hypertension; hypertrophy; cardiac function; cardiovascular physiology; cardiomyopathies; echocardiography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pulmonary arterial hypertension (PAH) continues to be a condition associated with high levels of morbidity and mortality. The currently available treatments for PAH were developed to restore an imbalance of vasoactive factors. These traditional medications include prostacyclin analogs and receptor agonists, phosphodiesterase 5 inhibitors, endothelin receptor antagonists, and cGMP activators.
However, the progress observed in the medical therapy of PAH patients over the past 15 years is not related to the discovery of new pathways, but to the evolution and testing of new drugs and strategies for combination therapy, and the escalation of treatments based on the systematic assessment of clinical response. These medications prolong life, but mortality remains unacceptably high. Although PAH is a disorder of pulmonary vasculature, right ventricle function is the main prognostic marker and should therefore also be the focus of more detailed analysis for the development of new drugs.
This Special Issue will pay attention to the recent advances in PAH research. We encourage investigators to submit original (basic and translational) research articles and reviews to this Special Issue with the purpose of providing mechanistic insights and deciphering novel diagnostic tools and new treatments for PAH.
Topics include, but are not limited to, the following areas:
- Cellular, molecular and/or hemodynamic mechanisms that drive PAH;
- The role of epigenetics in the pathogenesis of PAH;
- Potential new treatments for PAH;
- Repurposing established drugs for the resolution of PAH;
- New perspectives on direct therapies for right heart failure in PAH.
Dr. Rui Adão
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pulmonary arterial hypertension
- right ventricle
- right heart failure
- therapy
- vascular disease
- translational research
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