Advances in Immunometabolism: Molecular Pathways, Regulatory Networks, and Therapeutic Opportunities
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 109
Special Issue Editor
Special Issue Information
Dear Colleagues,
Immunometabolism has emerged as a rapidly evolving field that explores the dynamic interplay between metabolic pathways and immune-cell function in health and disease. Metabolic reprogramming is now recognized as a central determinant of immune-cell activation, differentiation, effector function, and exhaustion, thereby influencing the development and progression of cancer, autoimmune disorders, chronic inflammation, infectious diseases, and metabolic syndromes. Recent advances have highlighted the importance of glycolysis, oxidative phosphorylation, lipid metabolism, amino acid metabolism, mitochondrial function, redox balance, and metabolite-driven signaling in shaping both innate and adaptive immune responses.
This Special Issue aims to provide an updated overview of the molecular mechanisms and regulatory networks underlying immunometabolism, as well as their diagnostic, prognostic, and therapeutic implications. We welcome original research articles, reviews, and perspectives addressing basic, translational, and clinical aspects of immunometabolism. Topics of interest include, but are not limited to, immune-cell metabolic rewiring, immunometabolic checkpoints, inflammatory signaling, the tumor microenvironment, host–pathogen interactions, biomarkers of immune dysfunction, and metabolism-based therapeutic strategies. By bringing together current discoveries and emerging concepts, this Special Issue seeks to deepen our understanding of immunometabolism and support the development of innovative targeted interventions.
Dr. Sebastian Mertowski
Guest Editor
Manuscript Submission Information
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Keywords
- immunometabolism
- metabolic reprogramming
- immune-cell signaling
- inflammation
- tumor microenvironment
- mitochondrial dysfunction
- oxidative stress
- immunometabolic checkpoints
- biomarkers
- targeted therapy
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