Phenotypes and Endotypes in Interstitial Lung Diseases—Second Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 20
Special Issue Editor
Interests: interstitial lung disease; pulmonary fibrosis; orphan lung diseases; non-cystic fibrosis bronchiectasis; pneumonia/pulmonary infection; sarcoidosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Interstitial lung diseases (ILDs) are a heterogeneous group of more than 200 entities of either known or unknown etiology. The heterogeneity seen in ILDs manifests at many levels, including their symptoms, disease course, radiological and histological features, and biological underpinnings. This heterogeneity has been a substantial barrier to understanding the mechanisms of these diseases and developing effective and personalized treatments. Despite the growing interest and clinical research into ILDs, the management of patients remains sub-optimal, mainly because of the limited knowledge of the diseases’ pathogenesis, the highly variable and unpredictable behavior of the diseases, and their heterogeneous responses to treatment. Recent data suggest that different ILDs may share similar pathogenetic and biological pathways and thus be amenable to the same treatment. A paradigmatic example is the progressive pulmonary fibrosis (PPF) phenotype, in which nintedanib, a tyrosine kinase inhibitor targeting the PDGF and several other growth factors, has shown efficacy regardless of ILD etiology. A growing amount of evidence points towards the subgroup characterization of ILDs through endotypes, which are defined by specific genetic and molecular biomarkers. Thus, the future of ILDs lies in precision medicine approaches that are based on phenotypic and endotypic features. The aim of this Special Issue is to outline the status of knowledge in this field.
Dr. Francesco Amati
Guest Editor
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Keywords
- interstitial lung diseases (ILDs)
- heterogeneity
- pathogenesis
- progressive pulmonary fibrosis (PPF)
- molecular biomarkers
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Related Special Issue
- Phenotypes and Endotypes in Interstitial Lung Diseases in Biomedicines (6 articles)
