Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondrion-Targeting Agents for Tumor Therapy
edited by
submission deadline 30 Nov 2025 | Viewed by 165 | Submission Open
Keywords: mitochondria; cell signaling; apoptosis; cancer therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances of Microbiome in Human Cancers
edited by
submission deadline 30 Nov 2025 | Viewed by 145 | Submission Open
Keywords: human microbiome; gut microbiota; tumor-resident microbes; translational research; biomarkers; computational biology
(This special issue belongs to the Section Cancer Biology and Oncology)
Decoding Colorectal Cancer: Innovations in Biomarkers, Microbiota, and Therapeutic Resistance
edited by
submission deadline 30 Nov 2025 | Viewed by 138 | Submission Open
Keywords: colorectal cancer; tumor biomarkers; nanomaterials; drug delivery; microbiome– tumor interaction; therapeutic resistance; exosomes; tumor microenvironment; prognostic model; neoadjuvant therapy; conversion therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in the Pathogenesis and Treatment of Acute Myeloid Leukemia—2nd Edition submission deadline 30 Nov 2025 | Viewed by 137 | Submission Open
Keywords: acute myeloid leukemia; target therapies; molecular pathogenesis; biological therapy; precision medicine
(This special issue belongs to the Section Cancer Biology and Oncology)
Novel Biomaterials and Tissue Engineering Approaches in Periodontal Regeneration
edited by
submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open
Keywords: periodontium; tissue engineering; regenerative medicine; biomaterials; bioprinting; mesenchymal stem/stromal cells; senescence; aging; advanced therapeutics
(This special issue belongs to the Section Biomedical Engineering and Materials)
Coronary Artery Disease: Current Evidence and Future Perspectives
edited by Tadateru Takayama
submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open
Keywords: coronary artery disease; lipid-lowering therapy; residual risk; small dense LDL; lipoprotein(a); endothelial dysfunction; oxidative stress; inflammation; biomarkers; cardiovascular prevention
(This special issue belongs to the Section Molecular and Translational Medicine)
Pathogenesis, Diagnosis, and Treatment of Prostate Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 133 | Submission Open
Keywords: prostate cancer  ; molecular imaging; PET/CT; PSMA (prostate-specific membrane antigen); theranostics; radiopharmaceutical therapy; diagnosis and staging; radiology; targeted therapy; tumor microenvironment
(This special issue belongs to the Section Molecular and Translational Medicine)
Clinical Advances in Hepatocellular Carcinoma
edited by Mohamed A. Abd El Aziz
submission deadline 30 Nov 2025 | Viewed by 124 | Submission Open
Keywords: hepatocellular cancer; liver cirrhosis; chemotherapy; immunotherapy; radiofrequency ablation; microwave ablation
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in Neurophysiology and the Treatment of Parkinson’s Disease
edited by
submission deadline 30 Nov 2025 | Viewed by 120 | Submission Open
Keywords: movement disorders; hypokinetic movement disorders; Parkinson’ s disease; levodopa; treatment; neurophysiology; neuroplasticity; motor learning
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Small Intestinal Bacterial Overgrowth and Antimicrobial submission deadline 30 Nov 2025 | Viewed by 118 | Submission Open
Keywords: small intestine bacterial overgrowth; antibiotics; probiotics; gut microbiome
(This special issue belongs to the Section Molecular and Translational Medicine)
Engineering Extracellular Matrix (ECM)-Based Scaffold Biomaterials for Cancer Treatment
edited by
submission deadline 30 Nov 2025 | Viewed by 116 | Submission Open
Keywords: extracellular matrix; biomaterials; immunomodulatory agents; cancer immunotherapy; sustained delivery; drug delivery; tumor modeling; 3D model; therapeutic response; decellularized ECM
(This special issue belongs to the Section Gene and Cell Therapy)
The Preparation of an Exosome/Liposomal Nano-Drug Delivery System and Its Application in the Treatment of Inflammatory Bowel Disease
edited by and
submission deadline 30 Nov 2025 | Viewed by 115 | Submission Open
Keywords: exosomes; liposomes; nano-drug delivery systems; inflammatory bowel disease (IBD); targeted therapy; mucosal drug delivery; drug encapsulation; immunomodulation; nanomedicine; extracellular vesicles; personalized medicine
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Innovative Therapies for Neurodegenerative Diseases submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open
Keywords: nanotechnology-based therapies; cellular and regenerative therapies; stem cell therapy; gene therapy and RNA interference; protein aggregation inhibitors; neuroinflammation modulators; mitochondrial dysfunction-targeted drugs; preclinical and clinical trials
(This special issue belongs to the Section Gene and Cell Therapy)
Basic and Clinical Research of Psychiatric Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 104 | Submission Open
Keywords: psychiatric diseases; anxiety disorder; PTSD; schizophrenia; Alzheimer’ s disease; autism spectrum disorder; depression
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research in Congenital Heart Disease (CHD)
edited by Paul Philipp Heinisch
submission deadline 30 Nov 2025 | Viewed by 104 | Submission Open
Keywords: congenital heart disease (CHD); biomaterials; imaging modalities
(This special issue belongs to the Section Molecular and Translational Medicine)
From Cell Dysfunction to Prothrombotic Disorders: Molecular Pathways and Clinical Implications
edited by
submission deadline 30 Nov 2025 | Viewed by 104 | Submission Open
Keywords: prothrombotic disorder; cellular dysfunction; hemostatic balance; thrombosis; novel biomarkers; antithrombotic therapies
(This special issue belongs to the Section Cell Biology and Pathology)
Structure-Based Drug Molecule Design and Organic Synthesis
edited by
submission deadline 30 Nov 2025 | Viewed by 104 | Submission Open
Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Nanoparticles and Biomaterials: Pioneering Innovations in Biomedical Device Engineering
edited by Eleni Papachristou
submission deadline 30 Nov 2025 | Viewed by 103 | Submission Open
Keywords: nanoparticle NPs; biomaterials; drug delivery; mRNA delivery; antimicrobial activity; cancer; tissue regeneration; differentiation
(This special issue belongs to the Section Nanomedicine and Nanobiology)
Advances in Pharmacology of Pain and Inflammation
edited by Fernanda Regina de Castro Almeida and Francisco De Assis Oliveira
submission deadline 30 Nov 2025 | Viewed by 99 | Submission Open
Keywords: natural products; chronic pain; neuropathies; oncological pain; anti-inflammatory activity; pulmonary emphysema
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Mechanisms of Cellular Senescence and Inflammation in Cardiovascular Disease
edited by Sivareddy Kotla
submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open
Keywords: cellular senescence; inflammation; cardiovascular disease
(This special issue belongs to the Section Cell Biology and Pathology)
Gut Microbiota and Cancers of the GI Tract: Role in Regulation, Prevention and Therapy
edited by Luka Bočkor and
submission deadline 30 Nov 2025 | Viewed by 89 | Submission Open
Keywords: gut microbiota; gastrointestinal cancers; gastrointestinal microbiota; anti-cancer therapies
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Advancing Pharmacogenetics and Pharmacogenomics in Pre-Clinical Research: Unveiling New Avenues for Precision Medicine
edited by and
submission deadline 30 Nov 2025 | Viewed by 87 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; precision medicine; individualized medicine
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Activation and Regulation of NLRP3 Inflammasome
edited by
submission deadline 30 Nov 2025 | Viewed by 85 | Submission Open
Keywords: NLRP3 inflammasome; innate immunity; inflammation; pyroptosis; caspase-1; IL-1β ; IL-18; DAMPs; PAMPs; inflammasome inhibitors; post-translational modifications; chronic inflammatory diseases; metabolic disorders; neurodegenerative diseases; therapeutic targeting
(This special issue belongs to the Section Molecular and Translational Medicine)
Immunological Avalanches: Understanding Immune System Instability in Lupus, IgA Nephropathy, and Transplant Rejection
edited by , Giuseppe Gigliotti and Angelo Ferrantelli
submission deadline 30 Nov 2025 | Viewed by 82 | Submission Open
Keywords: immunological avalanche; lupus nephritis; IgA nephropathy; transplant rejection; complement dysregulation
(This special issue belongs to the Section Immunology and Immunotherapy)
Advances in Medically Assisted Reproduction submission deadline 30 Nov 2025 | Viewed by 81 | Submission Open
Keywords: infertility; medically assisted reproduction; reproductive endocrinology; clinical embryology; genetics; artificial intelligence; epigenetics; precision medicine; evidence-based medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Human Dental Stem Cells: The Last 25 Years submission deadline 30 Nov 2025 | Viewed by 78 | Submission Open
Keywords: dental stem cells; regenerative dentistry; differentiation; periodontitis
(This special issue belongs to the Section Cell Biology and Pathology)
Recent Advances in the Molecular Biology of Transplantation
edited by Anil S. Paramesh
submission deadline 30 Nov 2025 | Viewed by 74 | Submission Open
Keywords: donor-derived cell-free DNA; Torque Teno Virus monitoring; gene expression profiling; kidney/pancreas transplants
(This special issue belongs to the Section Immunology and Immunotherapy)
Advances in Human Immunodeficiency Virus (HIV): Past, Present and Future
edited by
submission deadline 30 Nov 2025 | Viewed by 62 | Submission Open
Keywords: HIV latency; ART; HIV reservoirs; NeuroHIV; immune activation; HIV cure strategies; virus– host interactions; HIV comorbidities; HIV and ageing; translational HIV research
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Fabry Disease: From Molecular Insights to Innovative Therapeutics
edited by and Concetto Sessa
submission deadline 10 Dec 2025 | 6 articles | Viewed by 12425 | Submission Open
Keywords: fabry disease; lysosomal storage disorder; GLA gene mutations; enzyme replacement therapy; chaperone therapy; physical activity; imagining
(This special issue belongs to the Section Molecular and Translational Medicine)
Hepatotoxicity: From Pathology to Novel Therapeutic Approaches (2nd Edition)
edited by
submission deadline 15 Dec 2025 | 2 articles | Viewed by 4122 | Submission Open
Keywords: cell death; reactive metabolites; oxidative stress; stress signaling; mitochondria; adaptive immunity; HLA associations; hepatotoxicity; drugs; liver injury; adverse drug reaction; drug-induced autoimmune hepatitis; idiosyncratic-drug-induced liver injury; bile acid; drug-induced cholestasis; hepatotoxins; steatosis; fibrosis
(This special issue belongs to the Section Molecular and Translational Medicine)
Extracellular Matrix in Health and Disorders (2nd Edition)
edited by
submission deadline 15 Dec 2025 | Viewed by 108 | Submission Open
Keywords: ECM; connective tissue; healthy tissues; pathological tissues; imaging; drug targets; markers; dermis; bone; tendon
(This special issue belongs to the Section Molecular and Translational Medicine)
Personalized Treatment in Cancer Research, Second Edition submission deadline 30 Dec 2025 | Viewed by 76 | Submission Open
Keywords: cancer; personalized medicine; personalized treatment; pharmacogenetics; pharmacokinetics; chemotherapy; adjuvant treatment; therapeutic drug monitoring
(This special issue belongs to the Section Cancer Biology and Oncology)
SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of Vaccinations submission deadline 31 Dec 2025 | 7 articles | Viewed by 26310 | Submission Open
Keywords: SARS-CoV-2 complications; SARS-CoV2 prognostic and predictive biomarkers; long COVID-19 and autoimmune disease; COVID-19 and microbiome; artificial intelligence
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies submission deadline 31 Dec 2025 | 8 articles | Viewed by 15331 | Submission Open
Keywords: neurological diseases; neurodegenerative diseases; stroke; multiple sclerosis; epilepsy; neuromuscular disorders; demyelinating diseases; traumatic brain injury; clinical neurophysiology; neuroimaging; genetics; neuropsychological tests; molecular and cellular mechanisms; biomarkers; diagnosis and therapeutics; prognosis; neurorehabilitation
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches
edited by and Valentina Mercurio
submission deadline 31 Dec 2025 | 9 articles | Viewed by 11127 | Submission Open
Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research on Heart Failure and Heart Transplantation submission deadline 31 Dec 2025 | 9 articles | Viewed by 10779 | Submission Open
Keywords: heart failure; heart transplantation; DBD (donation after brain death); DCD (donation after cardiac death); cardiac arrest; ischemic time and reperfusion injury; myocardial damage; preservation techniques; post-transplant outcomes
(This special issue belongs to the Section Molecular and Translational Medicine)
Tumor Immune Microenvironment and Novel Strategies for Cancer Immunotherapy
edited by Sidra Islam
submission deadline 31 Dec 2025 | 6 articles | Viewed by 9858 | Submission Open
Keywords: tumor microenvironment cancer immunotherapy; immune markers; tumor infilterating immune cells; tumors
(This special issue belongs to the Section Immunology and Immunotherapy)
Challenges in the Diagnosis and Treatment of Parkinson’s Disease
edited by Iro Boura and Cleanthe Spanaki
submission deadline 31 Dec 2025 | 5 articles | Viewed by 9750 | Submission Open
Keywords: Parkinson’ s disease; diagnosis; treatment; pathophysiology; biomarkers; prodromal; advanced therapies; subtypes; imaging; genetic
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advanced Research in Neuroprotection
edited by Evangelia Kesidou, Iliana Michailidou and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 9569 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood– brain barrier
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Mechanisms, Implications, and Therapeutic Targets in Infectious Diseases
edited by Mihai Lazăr and Oana Săndulescu
submission deadline 31 Dec 2025 | 5 articles | Viewed by 9099 | Submission Open
Keywords: infectious diseases; virus; antibiotics; pathophysiology; molecular mechanism; therapeutic management
(This special issue belongs to the Section Immunology and Immunotherapy)
Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches submission deadline 31 Dec 2025 | 3 articles | Viewed by 9048 | Submission Open
Keywords: cellular senescence; senescence-associated secretory phenotype; aging; senolytics; senomorphics; senoreverters; therapeutics
(This special issue belongs to the Section Cell Biology and Pathology)
Role of Factors in Embryo Implantation and Placental Development
edited by and Valentina Lacconi
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8302 | Submission Open
Keywords: placental development; implantation; embryo development; pregnancy disorders; endometrium; implantation failure; recurrent pregnancy loss; decidualization
(This special issue belongs to the Section Molecular and Translational Medicine)
Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7791 | Submission Open
Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Biomarker and Treatments for Diabetic Neuropathy
edited by Arun V. Krishnan and Tushar Issar
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5898 | Submission Open
Keywords: diabetic peripheral neuropathy; type 1 diabetes; type 2 diabetes; glucagon-like peptide-1 receptor agonists; metabolic syndrome; in vivo corneal confocal microscopy; nerve ultrasonography; obesity; exercise
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Traumatic CNS Injury: From Bench to Bedside (2nd Edition)
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5638 | Submission Open
Keywords: neurotrauma; traumatic brain injury; translational science; bench to bedside; neuroprotection
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
The Promise and Challenge of Induced Pluripotent Stem Cells (iPSCs): 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5305 | Submission Open
Keywords: iPSC; cell differentiation; disease model; disease-in-a-dish; body-on-a-chip; CRISPR/Cas9; gene edition; stem cell therapy; cell transplantation; translational
(This special issue belongs to the Section Molecular and Translational Medicine)
Biological Therapies for Asthma: Targeting Type 1 and Type 2 Inflammation
edited by Mohammad Irshad Reza and Nilesh Sudhakar Ambhore
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4858 | Submission Open
Keywords: asthma endotypes; type 1 inflammation; type 2 inflammation; biological therapies for asthma; non-type 2 asthma; cytokine pathways in asthma; precision medicine in asthma; inflammatory biomarkers in asthma; Th1/Th2 immune responses
(This special issue belongs to the Section Molecular and Translational Medicine)
Epigenetic Regulation in Cancer Progression
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4694 | Submission Open
Keywords: cancer progression; epigenetic regulation; gene expression; dysregulation; therapeutic targets
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Advances in Hepatology
edited by Yuanwen Chen
submission deadline 31 Dec 2025 | 5 articles | Viewed by 4554 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); alcohol-associated liver disease (ALD); alcohol-associated hepatitis; viral hepatitis; liver cancer; autoimmune liver diseases; liver fibrosis; gut microbiota; neuroimmune; inflammatory mechanisms; oxidative stress; reversibly oxidized human non-mercaptalbumin-1; irreversibly oxidized human non-mercaptalbumin-2 (HNA2)
(This special issue belongs to the Section Molecular and Translational Medicine)
Neurotransmitters in Health and Diseases
edited by and Krisztina Csabafi
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4277 | Submission Open
Keywords: neurotransmitters; GABA; dopamine; glutamate; acetylcholine; neurohormones; neuromodulators
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
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